Now showing items 1-11 of 11

    • Coronary CT Angiography Versus Standard Emergency Department Evaluation for Acute Chest Pain and Diabetic Patients: Is There Benefit With Early Coronary CT Angiography?: Results of the Randomized Comparative Effectiveness ROMICAT II Trial 

      Truong, Quynh A.; Schulman‐Marcus, Joshua; Zakroysky, Pearl; Chou, Eric T.; Nagurney, John T.; Fleg, Jerome L.; Schoenfeld, David A.; Udelson, James E.; Hoffmann, Udo; Woodard, Pamela K. (John Wiley and Sons Inc., 2016)
      Background: Cardiac computed tomography angiography (CCTA) reduces emergency department length of stay compared with standard evaluation in patients with low‐ and intermediate‐risk acute chest pain. Whether diabetic patients ...
    • Design and Initial Results of a Multi-Phase Randomized Trial of Ceftriaxone in Amyotrophic Lateral Sclerosis 

      Berry, James Dale; Shefner, Jeremy M.; Conwit, Robin; Schoenfeld, David Alan; Keroack, Myles; Felsenstein, Donna; Krivickas, Lisa; David, William Samuel; Vriesendorp, Francine; Pestronk, Alan; Caress, James B.; Katz, Jonathan; Simpson, Ericka; Rosenfeld, Jeffrey; Pascuzzi, Robert; Glass, Jonathan; Rezania, Kourosh; Rothstein, Jeffrey D.; Greenblatt, David J.; Cudkowicz, Merit Ester (Public Library of Science, 2013)
      Objectives: Ceftriaxone increases expression of the astrocytic glutamate transporter, EAAT2, which might protect from glutamate-mediated excitotoxicity. A trial using a novel three stage nonstop design, incorporating Phases ...
    • Does Glucose Variability Influence the Relationship Between Mean Plasma Glucose and \(HbA_{1c}\) Levels in Type 1 and Type 2 Diabetic Patients? 

      Kuenen, Judith C.; Borg, Rikke; Kuik, Dirk J.; Zheng, Zheng; Schoenfeld, David Alan; Diamant, Michaela; Nathan, David Matthew; Heine, Robert J. (American Diabetes Association, 2011)
      Objective: The A1C-Derived Average Glucose (ADAG) study demonstrated a linear relationship between \(HbA_{1c}\) and mean plasma glucose (MPG). As glucose variability (GV) may contribute to glycation, we examined the ...
    • A Genomic Storm in Critically Injured Humans 

      Mindrinos, Michael N.; Seok, Junhee; Cuschieri, Joseph; Cuenca, Alex G.; Hayden, Douglas L.; Hennessy, Laura; Moore, Ernest E.; Minei, Joseph P.; Bankey, Paul E.; Sperry, Jason; Nathens, Avery B.; Billiar, Timothy R.; Brownstein, Bernard H.; Mason, Philip H.; Baker, Henry V.; Finnerty, Celeste C.; Jeschke, Marc G.; López, M. Cecilia; Klein, Matthew B.; Gamelli, Richard L.; Gibran, Nicole S.; Arnoldo, Brett; Xu, Weihong; Zhang, Yuping; Calvano, Steven E.; McDonald-Smith, Grace P.; Storey, John D.; Moldawer, Lyle L.; Herndon, David N.; Lowry, Stephen F.; Maier, Ronald V.; Davis, Ronald W.; Xiao, Wenzhong; Gao, Hong; Johnson, Jeffrey L.; West, Michael A.; Schoenfeld, David Alan; Cobb, Joseph Perren; Warren, H. Shaw; Tompkins, Ronald Gary (The Rockefeller University Press, 2011)
      Human survival from injury requires an appropriate inflammatory and immune response. We describe the circulating leukocyte transcriptome after severe trauma and burn injury, as well as in healthy subjects receiving low-dose ...
    • Outcome-Driven Cluster Analysis with Application to Microarray Data 

      Hsu, Jessie J.; Finkelstein, Dianne M.; Schoenfeld, David A. (Public Library of Science, 2015)
      One goal of cluster analysis is to sort characteristics into groups (clusters) so that those in the same group are more highly correlated to each other than they are to those in other groups. An example is the search for ...
    • Outcome-Driven Clustering of Microarray Data 

      Hsu, Jessie (2012-09-17)
      The rapid technological development of high-throughput genomics has given rise to complex high-dimensional microarray datasets. One strategy for reducing the dimensionality of microarray experiments is to carry out a cluster ...
    • Oxytocin reduces caloric intake in men 

      Lawson, Elizabeth A.; Marengi, Dean A.; DeSanti, Rebecca L.; Holmes, Tara M.; Schoenfeld, David A.; Tolley, Christiane J. (2015)
      Objective: Preclinical studies indicate that oxytocin is anorexigenic and has beneficial metabolic effects. Oxytocin effects on nutrition and metabolism in humans are not well defined. We hypothesized that oxytocin would ...
    • A photoactivable multi-inhibitor nanoliposome for tumour control and simultaneous inhibition of treatment escape pathways 

      Spring, Bryan Q.; Sears, R. Bryan; Zheng, Lei Zak; Mai, Zhiming; Watanabe, Reika; Sherwood, Margaret E.; Schoenfeld, David A.; Pogue, Brian W.; Pereira, Stephen P.; Villa, Elizabeth; Hasan, Tayyaba (2015)
      Nanoscale drug delivery vehicles can facilitate multimodal therapies of cancer by promoting tumour-selective drug release. However, few are effective because cancer cells develop ways to resist and evade treatment. Here, ...
    • Proof-of-Concept, Randomized, Controlled Clinical Trial of Bacillus-Calmette-Guerin for Treatment of Long-Term Type 1 Diabetes 

      Faustman, Denise Louise; Wang, Limei; Okubo, Yoshiaki; Burger, Douglas E.; Ban, Liqin; Man, Guotong; Zheng, Hui; Schoenfeld, David Alan; Pompei, Richard; Avruch, Joseph; Nathan, David Matthew (Public Library of Science, 2012)
      Background: No targeted immunotherapies reverse type 1 diabetes in humans. However, in a rodent model of type 1 diabetes, Bacillus Calmette-Guerin (BCG) reverses disease by restoring insulin secretion. Specifically, it ...
    • Rank-Based Methods for Survival Data With Multiple Outcomes 

      Ramchandani, Ritesh (2015-08-27)
      In clinical studies of survival, additional endpoints on patients may be collected over the course of the study that give additional insight into a treatment's effect. We propose three methods to analyze right censored ...
    • Remote video auditing with real-time feedback in an academic surgical suite improves safety and efficiency metrics: a cluster randomised study 

      Overdyk, Frank J; Dowling, Oonagh; Newman, Sheldon; Glatt, David; Chester, Michelle; Armellino, Donna; Cole, Brandon; Landis, Gregg S; Schoenfeld, David; DiCapua, John F (BMJ Publishing Group, 2016)
      Importance Compliance with the surgical safety checklist during operative procedures has been shown to reduce inhospital mortality and complications but proper execution by the surgical team remains elusive. Objective: We ...