Browsing by Author "Ginty, David"
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The Emergence of Transcriptional Identity in Somatosensory Neurons
Sharma, Nikhil; Flaherty, Kali; Lezgiyeva, Karina; Wagner, Daniel E.; Klein, Allon; Ginty, David (Springer Science and Business Media LLC, 2020-01-08)Over a dozen morphologically and physiologically distinct primary somatosensory neuron subtypes report salient features of our internal and external environments. How specialized gene expression programs emerge during ... -
Extrinsic and intrinsic signals converge on the Runx1/CBFβ transcription factor for nonpeptidergic nociceptor maturation
Huang, Siyi; O'Donovan, Kevin J; Turner, Eric E; Zhong, Jian; Ginty, David D (eLife Sciences Publications, Ltd, 2015)The generation of diverse neuronal subtypes involves specification of neural progenitors and, subsequently, postmitotic neuronal differentiation, a relatively poorly understood process. Here, we describe a mechanism whereby ... -
Innervation of Thermogenic Adipose Tissue via a Calsyntenin 3β–S100b Axis
Zeng, Xing; Ye, Mengchen; Resch, Jon; Jedrychowski, Mark; Hu, Bo; Lowell, Bradford; Ginty, David; Spiegelman, Bruce (Springer Science and Business Media LLC, 2019-05)The sympathetic nervous system drives brown and beige adipocyte thermogenesis via release of norepinephrine from local axons. However, the molecular basis underlying the higher levels of sympathetic innervation of thermogenic ... -
Morphological, Physiological and Molecular Classification of Mouse Retinal Ganglion Cells
Qiao, Mu (2016-01-15)Visual information is conveyed from the retina to the brain through axons of retinal ganglion cells (RGCs). There are >20 different subtypes of RGCs, each of which detects specific features. Classification of RGC subtypes ... -
The structure and organization of lanceolate mechanosensory complexes at mouse hair follicles
Li, Lishi; Ginty, David D (eLife Sciences Publications, Ltd, 2014)In mouse hairy skin, lanceolate complexes associated with three types of hair follicles, guard, awl/auchene and zigzag, serve as mechanosensory end organs. These structures are formed by unique combinations of low-threshold ...