Now showing items 1-3 of 3

    • APP-BP1 Inhibits Aβ42 Levels by Interacting with Presenilin-1 

      Chen, Yuzhi; Bodles, Angela M; McPhie, Donna Louise; Neve, Rachael L; Mrak, Robert E; Griffin, W Sue T (BioMed Central, 2007)
      Background: The β-amyloid precursor protein (APP) is sequentially cleaved by the β- and then γ-secretase to generate the amyloid β-peptides Aβ40 and Aβ42. Increased Aβ42/Aβ40 ratios trigger amyloid plaque formations in ...
    • Functional implications of a psychiatric risk variant within CACNA1C in induced human neurons 

      Yoshimizu, Takao; Pan, Jen Q.; Mungenast, Alison E.; Madison, Jon M.; Su, Susan; Ketterman, Josh; Ongur, Dost; McPhie, Donna; Cohen, Bruce; Perlis, Roy; Tsai, Li-Huei (2014)
      Psychiatric disorders have clear heritable risk. Several large-scale genome-wide association studies have revealed a strong association between susceptibility for psychiatric disorders, including bipolar disease, schizophrenia, ...
    • Sprouty2 in the Dorsal Hippocampus Regulates Neurogenesis and Stress Responsiveness in Rats 

      Dow, Antonia L.; Lin, Tiffany V.; Chartoff, Elena H.; Potter, David; McPhie, Donna L.; Van’t Veer, Ashlee V.; Knoll, Allison T.; Lee, Kristen N.; Neve, Rachael L.; Patel, Tarun B.; Ongur, Dost; Cohen, Bruce M.; Carlezon, William A. (Public Library of Science, 2015)
      Both the development and relief of stress-related psychiatric conditions such as major depression (MD) and post-traumatic stress disorder (PTSD) have been linked to neuroplastic changes in the brain. One such change involves ...