Now showing items 1-7 of 7

    • A Feed-Forward Circuit of Endogenous PGC-1α and Estrogen Related Receptor α Regulates the Neuronal Electron Transport Chain 

      Bakshi, Rachit; Mittal, Shuchi; Liao, Zhixiang; Scherzer, Clemens R. (Hindawi Publishing Corporation, 2016)
      Peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) is a central regulator of cellular and mitochondrial metabolism. Cellular bioenergetics are critically important in “energy-guzzling” neurons, but the ...
    • Identification of genetic modifiers of age-at-onset for familial Parkinson’s disease 

      Hill-Burns, Erin M.; Ross, Owen A.; Wissemann, William T.; Soto-Ortolaza, Alexandra I.; Zareparsi, Sepideh; Siuda, Joanna; Lynch, Timothy; Wszolek, Zbigniew K.; Silburn, Peter A.; Mellick, George D.; Ritz, Beate; Scherzer, Clemens R.; Zabetian, Cyrus P.; Factor, Stewart A.; Breheny, Patrick J.; Payami, Haydeh (Oxford University Press, 2016)
      Parkinson’s disease (PD) is the most common cause of neurodegenerative movement disorder and the second most common cause of dementia. Genes are thought to have a stronger effect on age-at-onset of PD than on risk, yet ...
    • Lysosomal Dysfunction Promotes Cleavage and Neurotoxicity of Tau In Vivo 

      Khurana, Vikram; Elson-Schwab, Ilan; Fulga, Tudor Alexandru; Sharp, Katherine A.; Loewen, Carin A.; Mulkearns, Erin; Tyynelä, Jaana; Scherzer, Clemens; Feany, Mel B. (Public Library of Science, 2010)
      Expansion of the lysosomal system, including cathepsin D upregulation, is an early and prominent finding in Alzheimer's disease brain. Cell culture studies, however, have provided differing perspectives on the lysosomal ...
    • Metallothioneins as dynamic markers for brain disease in lysosomal disorders 

      Cesani, Martina; Cavalca, Eleonora; Macco, Romina; Leoncini, Giuseppe; Terreni, Maria Rosa; Lorioli, Laura; Furlan, Roberto; Comi, Giancarlo; Doglioni, Claudio; Zacchetti, Daniele; Sessa, Maria; Scherzer, Clemens R; Biffi, Alessandra (BlackWell Publishing Ltd, 2014)
      Objective: To facilitate development of novel disease-modifying therapies for lysosomal storage disorder (LSDs) characterized by nervous system involvement such as metachromatic leukodystrophy (MLD), molecular markers for ...
    • MHC-I expression renders catecholaminergic neurons susceptible to T-cell-mediated degeneration 

      Cebrián, Carolina; Zucca, Fabio A.; Mauri, Pierluigi; Steinbeck, Julius A.; Studer, Lorenz; Scherzer, Clemens R.; Kanter, Ellen; Budhu, Sadna; Mandelbaum, Jonathan; Vonsattel, Jean P.; Zecca, Luigi; Loike, John D.; Sulzer, David (2014)
      Subsets of rodent neurons are reported to express major histocompatibilty complex class I (MHC-I), but such expression has not been reported in normal adult human neurons. Here we provide evidence from immunolabel, RNA ...
    • Network Analysis Identifies SOD2 mRNA as a Potential Biomarker for Parkinson's Disease 

      Santiago, Jose A.; Scherzer, Clemens R.; Potashkin, Judith A. (Public Library of Science, 2014)
      Increasing evidence indicates that Parkinson's disease (PD) and type 2 diabetes (T2DM) share dysregulated molecular networks. We identified 84 genes shared between PD and T2DM from curated disease-gene databases. Nitric ...
    • Specifically neuropathic Gaucher's mutations accelerate cognitive decline in Parkinson's 

      Liu, Ganqiang; Boot, Brendon; Locascio, Joseph J.; Jansen, Iris E.; Winder‐Rhodes, Sophie; Eberly, Shirley; Elbaz, Alexis; Brice, Alexis; Ravina, Bernard; van Hilten, Jacobus J.; Cormier‐Dequaire, Florence; Corvol, Jean‐Christophe; Barker, Roger A.; Heutink, Peter; Marinus, Johan; Williams‐Gray, Caroline H.; Scherzer, Clemens R.; Scherzer, C.; Hyman, B.T.; Ivinson, A.J.; Trisini‐Lipsanopoulos, A.; Franco, D.; Burke, K.; Sudarsky, L.R.; Hayes, M.T.; Umeh, C.C.; Growdon, J.H.; Schwarzschild, M.A.; Hung, A.Y.; Flaherty, A.W.; Wills, A.‐M.; Mejia, N.I.; Gomperts, S.N.; Khurana, V.; Selkoe, D.J.; Yi, T.; Page, K.; Liao, Z.; Barker, R.; Foltynie, T.; Williams‐Gray, C.H.; Mason, S.; Winder‐Rhodes, S.; Breen, D.; Cummins, G.; Evans, J.; Corvol, J.‐C.; Brice, A.; Elbaz, A.; Mallet, A.; Vidailhet, M.; Bonnet, A.‐M.; Bonnet, C.; Grabli, D.; Hartmann, A.; Klebe, S.; Lacomblez, L.; Mangone, G.; Bourdain, F.; Brandel, J.‐P.; Derkinderen, P.; Durif, F.; Mesnage, V.; Pico, F.; Rascol, O.; Forlani, S.; Lesage, S.; Tahiri, K.; van Hilten, J.J.; Marinus, J.; Duong, K.; Dong, X.; Hutten, S.J.; Amr, S.S.; Shoulson, I.; Tanner, C.M.; Lang, A.E.; Nalls, M.A. (John Wiley and Sons Inc., 2016)
      Objective: We hypothesized that specific mutations in the β‐glucocerebrosidase gene (GBA) causing neuropathic Gaucher's disease (GD) in homozygotes lead to aggressive cognitive decline in heterozygous Parkinson's disease ...