Now showing items 1-18 of 18

    • Abacavir Alters the Transcription of Inflammatory Cytokines in Virologically Suppressed, HIV-Infected Women 

      MacLeod, Iain James; Rowley, Christopher Francis; Lockman, Shahin; Ogwu, Anthony; Moyo, Sikhulile; van Widenfelt, Erik; Mmalane, Mompati; Makhema, Joseph Moeketsi; Essex, Myron Elmer; Shapiro, Roger L. (International AIDS Society, 2012)
      Background: Abacavir (ABC) may be associated with a small, increased risk of myocardial infarction in HIV-infected adults, possibly related to cytokine-mediated inflammation. Methods: To evaluate the induction of inflammatory ...
    • Antiretroviral Regimens in Pregnancy and Breast-Feeding in Botswana 

      Shapiro, R.L.; Hughes, M.D.; Ogwu, Anthony; Kitch, Doug William; Lockman, Shahin; Moffat, C.; Makhema, Joseph Moeketsi; Moyo, S; Thior, Ibou; McIntosh, Kenneth; van Widenfelt, E.; Leidner, Jean A.; Powis, Kathleen Marie; Asmelash, A.; Tumbare, E.; Zwerski, S.; Sharma, Upasna; Handelsman, E.; Mburu, K.; Jayeoba, O.; Moko, E.; Souda, Shashidhar Vaman; Lubega, E.; Akhtar, M.; Wester, C William; Tuomola, R.; Snowden, W.; Martinez-Tristani, M.; Mazhani, L.; Essex, Myron Elmer (New England Journal of Medicine (NEJM/MMS), 2010)
      BACKGROUND: The most effective highly active antiretroviral therapy (HAART) to prevent mother-to-child transmission of human immunodeficiency virus type 1 (HIV-1) in pregnancy and its efficacy during breast-feeding are ...
    • An Augmented SMS Intervention to Improve Access to Antenatal CD4 Testing and ART Initiation in HIV-Infected Pregnant Women: A Cluster Randomized Trial 

      Dryden-Peterson, Scott; Bennett, Kara; Hughes, Michael D.; Veres, Adrian; John, Oaitse; Pradhananga, Rosina; Boyer, Matthew; Brown, Carolyn; Sakyi, Bright; van Widenfelt, Erik; Keapoletswe, Koona; Mine, Madisa; Moyo, Sikhulile; Asmelash, Aida; Siedner, Mark; Mmalane, Mompati; Shapiro, Roger L.; Lockman, Shahin (Public Library of Science, 2015)
      Background: Less than one-third of HIV-infected pregnant women eligible for combination antiretroviral therapy (ART) globally initiate treatment prior to delivery, with lack of access to timely CD4 results being a principal ...
    • Birth Weight for Gestational Age Norms for a Large Cohort of Infants Born to HIV-Negative Women in Botswana Compared with Norms for U.S.-Born Black Infants 

      Parekh, Natasha K; Binda, Kelebogile; Souda, Sajini; Essex, Max; Matthews, Lynn Turner; Ribaudo, Heather J.; Chen, Jennifer Yin-zu; Ogwu, Anthony; Makhema, Joseph Moeketsi; Lockman, Shahin; Shapiro, Roger L. (BioMed Central, 2011)
      Background: Standard values for birth weight by gestational age are not available for sub-Saharan Africa, but are needed to evaluate incidence and risk factors for intrauterine growth retardation in settings where HIV, ...
    • Cancer Incidence following Expansion of HIV Treatment in Botswana 

      Dryden-Peterson, Scott; Medhin, Heluf; Kebabonye-Pusoentsi, Malebogo; Seage, George R.; Suneja, Gita; Kayembe, Mukendi K. A.; Mmalane, Mompati; Rebbeck, Timothy; Rider, Jennifer R.; Essex, Myron; Lockman, Shahin (Public Library of Science, 2015)
      Background: The expansion of combination antiretroviral treatment (ART) in southern Africa has dramatically reduced mortality due to AIDS-related infections, but the impact of ART on cancer incidence in the region is ...
    • Cotrimoxazole Prophylaxis and Risk of Severe Anemia or Severe Neutropenia in HAART-Exposed, HIV-Uninfected Infants 

      Dryden-Peterson, Scott; Jayeoba, Oluwemimo; Hughes, Michael D.; Jibril, Haruna; McIntosh, Kenneth; Modise, Taolo A.; Asmelash, Aida; Powis, Kathleen M.; Essex, Max; Shapiro, Roger L.; Lockman, Shahin (Public Library of Science, 2013)
      Background: Prophylactic cotrimoxazole is recommended for infants born to HIV-infected mothers. However, cotrimoxazole may increase the risk of severe anemia or neutropenia. Methods: We compared the proportion of HIV-exposed ...
    • Estimated age and gender profile of individuals missed by a home-based HIV testing and counselling campaign in a Botswana community 

      Novitsky, Vlad; Bussmann, Hermann; Okui, Lillian; Logan, Andrew; Moyo, Sikhulile; van Widenfelt, Erik; Mmalane, Mompati; Lei, Quanhong; Holme, Molly P; Makhema, Joseph; Lockman, Shahin; Degruttola, Victor; Essex, M (International AIDS Society, 2015)
      Introduction: It would be useful to understand which populations are not reached by home-based HIV-1 testing and counselling (HTC) to improve strategies aimed at linking these individuals to care and reducing rates of ...
    • High Prevalence of Hypertension and Placental Insufficiency, but No In Utero HIV Transmission, among Women on HAART with Stillbirths in Botswana 

      Souda, Sajini; Parekh, Natasha; Binda, Kelebogile; Kayembe, Mukendi; Svab, Petr; Babitseng, Orphinah; Jimbo, William; Creek, Tracy; Essex, Max; Shapiro, Roger L.; Lockman, Shahin; Powis, Kathleen Marie; Makhema, Joseph Moeketsi; Roberts, Drucilla Jane (Public Library of Science, 2012)
      Background: Increased stillbirth rates occur among HIV-infected women, but no studies have evaluated the pathological basis for this increase, or whether highly active antiretroviral therapy (HAART) influences the etiology ...
    • HIV-1 Subtype C-Infected Individuals Maintaining High Viral Load as Potential Targets for the “Test-and-Treat” Approach to Reduce HIV Transmission 

      Baum, Marianna; Thior, Ibou; Asmelash, Aida; Campa, Adriana; van Widenfelt, Erik; Mine, Madisa; Moffat, Claire; Mmalane, Mompati; Gilbert, Peter; Novitsky, Vladimir A.; Wang, Rui; Bussmann, Hermann; Lockman, Shahin; Shapiro, Roger L.; Wester, Carolyn Negley; Wester, C William; Ogwu, Anthony; Musonda, Rosemary Mubanga; Moyo, Sikhulile; Makhema, Joseph Moeketsi; Marlink, Richard George; Seage, George R.; De Gruttola, Victor Gerard; Essex, Myron Elmer (Public Library of Science, 2010)
      The first aim of the study is to assess the distribution of HIV-1 RNA levels in subtype C infection. Among 4,348 drug-naïve HIV-positive individuals participating in clinical studies in Botswana, the median baseline plasma ...
    • HIV-exposed children account for more than half of 24-month mortality in Botswana 

      Zash, Rebecca; Souda, Sajini; Leidner, Jean; Ribaudo, Heather; Binda, Kelebogile; Moyo, Sikhulile; Powis, Kathleen M.; Petlo, Chipo; Mmalane, Mompati; Makhema, Joe; Essex, Max; Lockman, Shahin; Shapiro, Roger (BioMed Central, 2016)
      Background: The contribution of HIV-exposure to childhood mortality in a setting with widespread antiretroviral treatment (ART) availability has not been determined. Methods: From January 2012 to March 2013, mothers were ...
    • Humoral Immune Pressure Selects for HIV-1 CXC-chemokine Receptor 4-using Variants 

      Lin, Nina; Gonzalez, Oscar A.; Registre, Ludy; Becerril, Carlos; Etemad, Behzad; Lu, Hong; Wu, Xueling; Lockman, Shahin; Essex, Myron; Moyo, Sikhulile; Kuritzkes, Daniel R.; Sagar, Manish (Elsevier, 2016)
      Although both C-C chemokine receptor 5 (CCR5)- and CXC chemokine receptor 4 (CXCR4)-using HIV-1 strains cause AIDS, the emergence of CXCR4-utilizing variants is associated with an accelerated decline in CD4 + T cells. It ...
    • Nevirapine- Versus Lopinavir/Ritonavir-Based Initial Therapy for HIV-1 Infection among Women in Africa: A Randomized Trial 

      Lockman, Shahin; Hughes, Michael David; Sawe, Fred; Zheng, Yu; McIntyre, James; Chipato, Tsungai; Asmelash, Aida; Rassool, Mohammed; Kimaiyo, Sylvester; Shaffer, Douglas; Hosseinipour, Mina; Mohapi, Lerato; Ssali, Francis; Chibowa, Margret; Amod, Farida; Halvas, Elias; Hogg, Evelyn; Alston-Smith, Beverly; Smith, Laura; Schooley, Robert; Mellors, John; Currier, Judith (Public Library of Science, 2012)
      Background: Nevirapine (NVP) is widely used in antiretroviral treatment (ART) of HIV-1 globally. The primary objective of the AA5208/OCTANE trial was to compare the efficacy of NVP-based versus lopinavir/ritonavir (LPV/r)-based ...
    • Phylogenetic Relatedness of Circulating HIV-1C Variants in Mochudi, Botswana 

      Novitsky, Vladimir; Bussmann, Hermann; Logan, Andrew; Moyo, Sikhulile; van Widenfelt, Erik; Okui, Lillian; Mmalane, Mompati; Baca, Jeannie; Buck, Lauren; Phillips, Eleanor; Tim, David; McLane, Mary Fran; Lei, Quanhong; Wang, Rui; Makhema, Joseph; Lockman, Shahin; DeGruttola, Victor; Essex, M. (Public Library of Science, 2013)
      Background: Determining patterns of HIV transmission is increasingly important for the most efficient use of modern prevention interventions. HIV phylogeny can provide a better understanding of the mechanisms underlying ...
    • Predictors of suboptimal CD4 response among women achieving virologic suppression in a randomized antiretroviral treatment trial, Africa 

      Asmelash, Aida; Zheng, Yu; Kaloustian, Kara Wools; Shaffer, Douglas; Sawe, Fred; Ogwu, Anthony; Salata, Robert; Currier, Judith; Hughes, Michael D; Lockman, Shahin (BioMed Central, 2014)
      Background: A subset of HIV-1 infected patients starting highly active antiretroviral treatment (HAART) experience suboptimal CD4 response (SCR) despite virologic suppression. We studied the rate of and risk factors for ...
    • Predictors of Timely Access of Oncology Services and Advanced-Stage Cancer in an HIV-Endemic Setting 

      Brown, Carolyn A.; Suneja, Gita; Tapela, Neo; Mapes, Abigail; Pusoentsi, Malebogo; Mmalane, Mompati; Hodgeman, Ryan; Boyer, Matthew; Musimar, Zola; Ramogola-Masire, Doreen; Grover, Surbhi; Nsingo-Bvochora, Memory; Kayembe, Mukendi; Efstathiou, Jason; Lockman, Shahin; Dryden-Peterson, Scott (AlphaMed Press, 2016)
      Background. Three-quarters of cancer deaths occur in resource-limited countries, and delayed presentation contributes to poor outcome. In Botswana, where more than half of cancers arise in HIV-infected individuals, we ...
    • Response to Antiretroviral Therapy after a Single, Peripartum Dose of Nevirapine 

      Lockman, Shahin; Shapiro, Roger L.; Smeaton, Laura Marie; Wester, Carolyn; Thior, Ibou; Stevens, Lisa; Chand, Fatima; Makhema, Joseph Moeketsi; Moffat, Claire; Asmelash, Aida; Ndase, Patrick; van Widenfelt, Peter Arimim Eri; Mazhani, Loeto; Novitsky, Vladimir A.; Lagakos, Stephen; Essex, Myron Elmer (New England Journal of Medicine (NEJM/MMS), 2007)
      BACKGROUND: A single dose of nevirapine during labor reduces perinatal transmission of human immunodeficiency virus type 1 (HIV-1) but often leads to viral nevirapine resistance mutations in mothers and infants. METHODS: ...
    • Unintended pregnancy, contraceptive use, and childbearing desires among HIV-infected and HIV-uninfected women in Botswana: across-sectional study 

      Mayondi, Gloria K.; Wirth, Kathleen; Morroni, Chelsea; Moyo, Sikhulile; Ajibola, Gbolahan; Diseko, Modiegi; Sakoi, Maureen; Magetse, Jane Dipuo; Moabi, Kebaiphe; Leidner, Jean; Makhema, Joseph; Kammerer, Betsy; Lockman, Shahin (BioMed Central, 2016)
      Background: Little is known about the impact of knowledge of HIV serostatus on pregnancy intention and contraceptive use in high-HIV-burden southern African settings in the era of widespread antiretroviral treatment ...
    • Vitamin D Insufficiency in HIV-infected Pregnant Women Receiving Antiretroviral Therapy is Not Associated With Morbidity, Mortality or Growth Impairment in Their Uninfected Infants in Botswana 

      Powis, Kathleen Marie; Lockman, Shahin; Smeaton, Laura Marie; Hughes, Michael David; Fawzi, Wafaie W.; Ogwu, Anthony; Moyo, Sikhulile; van Widenfelt, Erik; von Oettingen, Julia Elisabeth; Makhema, Joseph; Essex, Max; Shapiro, Roger L. (Ovid Technologies (Wolters Kluwer Health), 2014)
      Background Low maternal 25(OH)D (vitamin D) values have been associated with higher mortality and impaired growth among HIV-exposed uninfected (HEU) infants of antiretroviral (ART)-naïve women. These associations have ...