Now showing items 1-5 of 5

    • Designing Scalable Biological Interfaces 

      Marblestone, Adam Henry (2014-06-06)
      This thesis presents the analysis and design of biological interfacing technologies in light of a need for radical improvements in scalability. It focuses primarily on structural and functional neural data acquisition, but ...
    • Measuring Cation Dependent DNA Polymerase Fidelity Landscapes by Deep Sequencing 

      Zamft, Bradley; Marblestone, Adam Henry; Kording, Konrad; Schmidt, Daniel; Martin-Alarcon, Daniel; Tyo, Keith; Boyden, Edward S.; Church, George McDonald (Public Library of Science, 2012)
      High-throughput recording of signals embedded within inaccessible micro-environments is a technological challenge. The ideal recording device would be a nanoscale machine capable of quantitatively transducing a wide range ...
    • Molecular Threading: Mechanical Extraction, Stretching and Placement of DNA Molecules from a Liquid-Air Interface 

      Payne, Andrew C.; Andregg, Michael; Kemmish, Kent; Hamalainen, Mark; Bowell, Charlotte; Bleloch, Andrew; Klejwa, Nathan; Lehrach, Wolfgang; Schatz, Ken; Stark, Heather; Marblestone, Adam; Church, George; Own, Christopher S.; Andregg, William (Public Library of Science, 2013)
      We present “molecular threading”, a surface independent tip-based method for stretching and depositing single and double-stranded DNA molecules. DNA is stretched into air at a liquid-air interface, and can be subsequently ...
    • Physical principles for scalable neural recording 

      Marblestone, Adam H.; Zamft, Bradley M.; Maguire, Yael G.; Shapiro, Mikhail G.; Cybulski, Thaddeus R.; Glaser, Joshua I.; Amodei, Dario; Stranges, P. Benjamin; Kalhor, Reza; Dalrymple, David A.; Seo, Dongjin; Alon, Elad; Maharbiz, Michel M.; Carmena, Jose M.; Rabaey, Jan M.; Boyden, Edward S.; Church, George M.; Kording, Konrad P. (Frontiers Media S.A., 2013)
      Simultaneously measuring the activities of all neurons in a mammalian brain at millisecond resolution is a challenge beyond the limits of existing techniques in neuroscience. Entirely new approaches may be required, ...
    • Statistical Analysis of Molecular Signal Recording 

      Glaser, Joshua I.; Zamft, Bradley M.; Marblestone, Adam H.; Moffitt, Jeffrey R.; Tyo, Keith; Boyden, Edward S.; Church, George; Kording, Konrad P. (Public Library of Science, 2013)
      A molecular device that records time-varying signals would enable new approaches in neuroscience. We have recently proposed such a device, termed a “molecular ticker tape”, in which an engineered DNA polymerase (DNAP) ...