Browsing by Author "Karumanchi, Subbian"

Now showing items 1-19 of 19

    • The association of circulating angiogenic factors and HbA1c with the risk of preeclampsia in women with preexisting diabetes 

      Cohen, Allison L.; Wenger, Julia B.; James-Todd, Tamarra; Lamparello, Brooke M.; Halprin, Elizabeth Susannah; Serdy, Shanti; Fan, Shuling; Horowitz, Gary Leigh; Lim, Kee-Hak; Rana, Sarosh; Takoudes, Tamara C.; Wyckoff, Jennifer A.; Thadhani, Ravi I.; Karumanchi, Subbian Ananth; Brown, Florence Mavis (Informa UK Limited, 2014)
      Objective: To assess whether glycemic control, soluble fms-like tyrosine kinase 1 (sFlt1) and placental growth factor (PlGF) were associated with the development of preeclampsia (PE) or gestational hypertension (GHTN) in ...

    • Bioavailable Vitamin D Is More Tightly Linked to Mineral Metabolism than Total Vitamin D in Incident Hemodialysis Patients 

      Bhan, Ishir; Powe, Camille Elise; Berg, Anders Hayden; Ankers, Elizabeth; Wenger, Julia; Karumanchi, Subbian Ananth; Thadhani, Ravi Ishwar (Nature Publishing Group, 2012)
      Prior studies showed conflicting results regarding the association between 25-hydroxyvitamin D (25(OH)D) levels and mineral metabolism in end-stage renal disease. In order to determine whether the bioavailable vitamin D ...

    • Cardiac Angiogenic Imbalance Leads to Peripartum Cardiomyopathy 

      Patten, Ian S.; Farrell, Caitlin; Tudorache, Igor; Bauersachs, Johann; Hilfiker-Kleiner, Denise; Rana, Sarosh; Shahul, Sajid Saleem; Rowe, Glenn C; Jang, Cholsoon; Liu, Laura; Hacker, Michele Renee; Rhee, Julie S; Mitchell, John D.; Mahmood, Feroze-Ud-Den; Hess, Philip E.; Koulisis, Nicole; Khankin, Eliyahu; Burke, Suzanne Diana; Del Monte, Federica; Karumanchi, Subbian Ananth; Arany, Zoltan Pierre (Nature Publishing Group, 2012)
      Peripartum cardiomyopathy (PPCM) is an often fatal disease that affects pregnant women who are near delivery, and it occurs more frequently in women with pre-eclampsia and/or multiple gestation. The aetiology of PPCM, and ...

    • Circulating Angiogenic Factors and the Risk of Adverse Outcomes among Haitian Women with Preeclampsia 

      March, Melissa I.; Geahchan, Carl; Wenger, Julia; Raghuraman, Nandini; Berg, Anders; Haddow, Hamish; Mckeon, Bri Ann; Narcisse, Rulx; David, Jean Louis; Scott, Jennifer; Thadhani, Ravi; Karumanchi, S. Ananth; Rana, Sarosh (Public Library of Science, 2015)
      Objective: Angiogenic factors are strongly associated with adverse maternal and fetal outcomes among women with preterm preeclampsia (PE) in developed countries. We evaluated the role of angiogenic factors and their ...

    • Circulating anti-angiogenic factors during hypertensive pregnancy and increased risk of respiratory distress syndrome in preterm neonates 

      Wang, Alice; Holston, Alexander M.; Yu, Kai F.; Zhang, Jun; Toporsian, Mourad; Karumanchi, Subbian Ananth; Levine, Richard J. (Informa healthcare, 2012)
      Objective: To test the hypothesis that high circulating concen-trations of maternal anti-angiogenic factors are associated with increased risk of respiratory distress syndrome (RDS). Study Design: This is a nested case-control ...

    • Excess circulating angiopoietin-2 may contribute to pulmonary vascular leak in sepsis in humans 

      Parikh, Samir Mukund; Mammoto, Tadanori; Schultz, Aylit; Yuan, Hai-Tao; Christiani, David C.; Karumanchi, Subbian Ananth; Sukhatme, Vikas Pandurang (Public Library of Science, 2006)
      Background: Acute respiratory distress syndrome (ARDS) is a devastating complication of numerous underlying conditions, most notably sepsis. Although pathologic vascular leak has been implicated in the pathogenesis of ARDS ...

    • First-Trimester Follistatin-Like-3 Levels in Pregnancies Complicated by Subsequent Gestational Diabetes Mellitus 

      Thadhani, Ravi Ishwar; Powe, Camille Elise; Tjoa, May Lee; Khankin, Eliyahu; Ye, Jun; Ecker, Jeffrey Lawrence; Schneyer, Alan; Karumanchi, Subbian Ananth (American Diabetes Association, 2009)
      Objective: To determine whether maternal levels of follistatin-like-3 (FSTL3), an inhibitor of activin and myostatin involved in glucose homeostasis, are altered in the first trimester of pregnancies complicated by subsequent ...

    • Flt1, pregnancy, and malaria: Evolution of a complex interaction 

      Karumanchi, Subbian Ananth; Haig, David Addison (Proceedings of the National Academy of Sciences, 2008)

    • Gestational Age, Infant Birth Weight, and Subsequent Risk of Type 2 Diabetes in Mothers: Nurses’ Health Study II 

      James-Todd, Tamarra; Karumanchi, Subbian Ananth; Hibert, Eileen L.; Mason, Susan M.; Vadnais, Mary Alice; Hu, Frank B.; Rich-Edwards, Janet Wilson (Centers for Disease Control and Prevention (CDC), 2013)
      Introduction Women with a history of gestational diabetes mellitus (GDM) are at higher risk of developing type 2 diabetes (T2DM); however, little is known about the association between other common pregnancy complications ...

    • Induced Human Decidual NK-Like Cells Improve Utero-Placental Perfusion in Mice 

      Cavalli, Ricardo C.; Cerdeira, Ana Sofia; Pernicone, Elizabeth; Korkes, Henri A.; Burke, Suzanne D.; Rajakumar, Augustine; Thadhani, Ravi I.; Roberts, Drucilla J.; Bhasin, Manoj; Karumanchi, S. Ananth; Kopcow, Hernan D. (Public Library of Science, 2016)
      Decidual NK (dNK) cells, a distinct type of NK cell, are thought to regulate uterine spiral artery remodeling, a process that allows for increased blood delivery to the fetal-placental unit. Impairment of uterine spiral ...

    • PGC1α-dependent NAD biosynthesis links oxidative metabolism to renal protection 

      Tran, Mei T.; Zsengeller, Zsuzsanna K.; Berg, Anders H.; Khankin, Eliyahu V.; Bhasin, Manoj K.; Kim, Wondong; Clish, Clary B.; Stillman, Isaac E.; Karumanchi, S. Ananth; Rhee, Eugene P.; Parikh, Samir M. (2016)
      The energetic burden of continuously concentrating solutes against gradients along the tubule may render the kidney especially vulnerable to ischemia. Indeed, acute kidney injury (AKI) affects 3% of all hospitalized ...

    • Plasma Concentrations of Soluble Endoglin versus Standard Evaluation in Patients with Suspected Preeclampsia 

      Rana, Sarosh; Cerdeira, Ana Sofia Teixeira de; Wenger, Julia; Salahuddin, Saira; Lim, Kee-Hak; Ralston, Steven Joseph; Thadhani, Ravi Ishwar; Karumanchi, Subbian Ananth (Public Library of Science, 2012)
      Background: The purpose of this study was to compare plasma soluble endoglin (sEng) levels with standard clinical evaluation or plasma levels of other angiogenic proteins [soluble fms-like tyrosine kinase 1 (sFlt1) and ...

    • Pre-eclampsia, Soluble fms-like Tyrosine Kinase 1, and the Risk of Reduced Thyroid Function: Nested Case-Control and Population Based Study 

      Levine, Richard J; Vatten, Lars Johan; Horowitz, Gary Leigh; Qian, Cong; Romundstad, Pal R; Yu, Kai F; Hollenberg, Anthony Neil; Hellevik, Alf I; Asvold, Bjorn O; Karumanchi, Subbian Ananth (BMJ Publishing Group, 2009)
      Objective: To determine if pre-eclampsia is associated with reduced thyroid function during and after pregnancy. Design: Nested case-control study during pregnancy and population based follow-up study after pregnancy. ...

    • A prospective study of angiogenic markers and postmenopausal breast cancer risk in the prostate, lung, colorectal, and ovarian cancer screening trial 

      Falk, Roni T.; Staff, Annetine Cathrine; Bradwin, Gary; Karumanchi, S. Ananth; Troisi , Rebecca (Springer International Publishing, 2016)
      Purpose Pro-angiogenic factors are positively associated with breast tumor staging and poorer prognosis, but their role in the etiology of breast cancer has not been assessed. Methods: We measured serum levels of the ...

    • Protein carbamylation is associated with heart failure and mortality in diabetic patients with end stage renal disease 

      Drechsler, Christiane; Kalim, Sahir; Wenger, Julia B.; Suntharalingam, Pirianthini; Hod, Tammy; Thadhani, Ravi I.; Karumanchi, S. Ananth; Wanner, Christoph; Berg, Anders H. (2015)
      Serum carbamylated albumin (C-Alb) levels are associated with excess mortality in patients with diabetic end stage renal disease. To gain insight into the pathophysiology of carbamylation, we determined associations between ...

    • Soluble Erythropoietin Receptor Contributes to Erythropoietin Resistance in End-Stage Renal Disease 

      Khankin, Eliyahu; Mutter, Walter Peter; Tamez, Hector; Yuan, Hai-Tao; Karumanchi, Subbian Ananth; Thadhani, Ravi Ishwar (Public Library of Science, 2010)
      Background: Erythropoietin is a growth factor commonly used to manage anemia in patients with chronic kidney disease. A significant clinical challenge is relative resistance to erythropoietin, which leads to use of ...

    • Transcriptional Patterns in Peritoneal Tissue of Encapsulating Peritoneal Sclerosis, a Complication of Chronic Peritoneal Dialysis 

      Reimold, Fabian Raoul; Braun, Niko; Zsengellér, Zsuzsanna K.; Stillman, Isaac Ely; Karumanchi, Subbian Ananth; Toka, Hakan; Latus, Joerg; Fritz, Peter; Biegger, Dagmar; Segerer, Stephan; Alscher, M. Dominik; Bhasin, Manoj; Alper, Seth Leo (Public Library of Science, 2013)
      Encapsulating peritoneal sclerosis (EPS) is a devastating complication of peritoneal dialysis (PD), characterized by marked inflammation and severe fibrosis of the peritoneum, and associated with high morbidity and mortality. ...

    • Urinary Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Patients with Obstructive Sleep Apnea 

      Maski, Manish R.; Thomas, Robert J.; Karumanchi, S. Ananth; Parikh, Samir M. (Public Library of Science, 2016)
      Background: Obstructive sleep apnea (OSA) is a well-established risk factor for hypertension and cardiovascular morbidity and mortality. More recently, OSA has been implicated as an independent risk factor for chronic ...

    • VEGF and TGF-? are required for the maintenance of the choroid plexus and ependyma 

      Maharaj, Arindel S.R.; Walshe, Tony E.; Saint-Geniez, Magali; Venkatesha, Shivalingappa; Maldonado, Angel E.; Himes, Nathan C.; Matharu, Kabir S.; Karumanchi, Subbian Ananth; D'Amore, Patricia Ann (Rockefeller University Press, 2008)
      Although the role of vascular endothelial growth factor (VEGF) in developmental and pathological angiogenesis is well established, its function in the adult is less clear. Similarly, although transforming growth factor ...