Browsing by Author "Carman, Christopher"
Now showing items 1-5 of 5
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Actin foci facilitate activation of the phospholipase C-γ in primary T lymphocytes via the WASP pathway
Kumari, Sudha; Depoil, David; Martinelli, Roberta; Judokusumo, Edward; Carmona, Guillaume; Gertler, Frank B; Kam, Lance C; Carman, Christopher V; Burkhardt, Janis K; Irvine, Darrell J; Dustin, Michael L (eLife Sciences Publications, Ltd, 2015)Wiscott Aldrich Syndrome protein (WASP) deficiency results in defects in calcium ion signaling, cytoskeletal regulation, gene transcription and overall T cell activation. The activation of WASP constitutes a key pathway ... -
ERG is Required for the Differentiation of Embryonic Stem Cells along the Endothelial Lineage
Nikolova-Krstevski, Vesna; Yuan, Lei; Le Bras, Alexandra; Vijayaraj, Preethi; Kondo, Maiko; Gebauer, Marie-Isabel; Bhasin, Manoj; Carman, Christopher Vincent; Oettgen, Peter (BioMed Central, 2009)Background: The molecular mechanisms that govern stem cell differentiation along the endothelial lineage remain largely unknown. Ets related gene (ERG) has recently been shown to participate in the transcriptional regulation ... -
Release of cellular tension signals self-restorative ventral lamellipodia to heal barrier micro-wounds
Martinelli, Roberta; Kamei, Masataka; Sage, Peter T.; Massol, Ramiro; Varghese, Laya; Sciuto, Tracey; Toporsian, Mourad; Dvorak, Ann M.; Kirchhausen, Tomas; Springer, Timothy A.; Carman, Christopher V. (The Rockefeller University Press, 2013)Basic mechanisms by which cellular barriers sense and respond to integrity disruptions remain poorly understood. Despite its tenuous structure and constitutive exposure to disruptive strains, the vascular endothelium ... -
Soluble adhesion molecules as markers for sepsis and the potential pathophysiological discrepancy in neonates, children and adults
Zonneveld, Rens; Martinelli, Roberta; Shapiro, Nathan I; Kuijpers, Taco W; Plötz, Frans B; Carman, Christopher V (BioMed Central, 2014)Sepsis is a severe and life-threatening systemic inflammatory response to infection that affects all populations and age groups. The pathophysiology of sepsis is associated with aberrant interaction between leukocytes and ... -
T Lymphocyte–Endothelial Interactions: Emerging Understanding of Trafficking and Antigen-Specific Immunity
Carman, Christopher V.; Martinelli, Roberta (Frontiers Media S.A., 2015)Antigen-specific immunity requires regulated trafficking of T cells in and out of diverse tissues in order to orchestrate lymphocyte development, immune surveillance, responses, and memory. The endothelium serves as a ...