Browsing by Author "Sabatine, Marc"

Now showing items 1-5 of 5

    • Genetic Risk, Coronary Heart Disease Events, and the Clinical Benefit of Statin Therapy: An Analysis of Primary and Secondary Prevention Trials 

      Mega, Jessica L.; Stitziel, Nathan O.; Smith, J. Gustav; Chasman, Daniel; Caulfield, Mark; Devlin, James J.; Nordio, Francesco; Hyde, Craig L.; Cannon, Christopher; Sacks, Frank; Poulter, Neil; Sever, Peter S.; Ridker, Paul; Braunwald, Eugene; Melander, Olle; Kathiresan, Sekar; Sabatine, Marc (Elsevier BV, 2015-06-06)
      Background Genetic variants have been associated with the risk of coronary heart disease (CHD). We tested whether a composite of these variants could identify the risk of both incident as well as recurrent CHD events and ...

    • Lipoprotein(a) for Risk Assessment in Patients With Established Coronary Artery Disease 

      O, Michelle L.; Morrow, David Andrew; Tsimikas, Sotirios; Sloan, Sarah; Ren, Angela F.; Hoffman, Elaine; Desai, Nihar R.; Solomon, Scott David; Domanski, Michael; Arai, Kiyohito; Chiuve, Stephanie Elizabeth; Cannon, Christopher Paul; Sacks, Frank Martin; Sabatine, Marc Steven (Elsevier BV, 2014)
      OBJECTIVES: The purpose of this study was to assess the prognostic utility of lipoprotein(a) [Lp(a)] in individuals with coronary artery disease (CAD). BACKGROUND: Data regarding an association between Lp(a) and ...

    • Myeloid-related protein 8/14 and the risk of cardiovascular death or myocardial infarction after an acute coronary syndrome in the Pravastatin or Atorvastatin Evaluation and Infection Theraphy: Thrombolysis in Myocardial Infarction (PROVE IT-TIMI 22) trial 

      Morrow, David Andrew; Wang, Yunmei; Croce, Kevin James; Sakuma, Masashi; Sabatine, Marc Steven; Gao, Huiyun; Pradhan, Aruna Das; Healy, Aileen M.; Buros, Jacki; McCabe, Carolyn; Libby, Peter; Cannon, Christopher Paul; Braunwald, Eugene; Simon, Daniel I. (Elsevier BV, 2008)
      Background Using a transcriptional profiling approach, we recently identified myeloid-related protein 8/14 (MRP-8/14) to be expressed by platelets during acute myocardial infarction (MI). Elevated concentrations of MRP-8/14 ...

    • Myocardial Infarction Accelerates Atherosclerosis 

      Leuschner, Florian; Robbins, Clinton; Iwamoto, Yoshiko; Thompson, Brian; Carlson, Alicia L.; Heidt, Timo; Lasitschka, Felix; Etzrodt, Martin; Waterman, Peter; Waring, Michael T.; Chicoine, Adam T.; van der Laan, Anja M.; Niessen, Hans W.M.; Piek, Jan J.; Rubin, Barry B.; Butany, Jagdish; Katus, Hugo A.; Murphy, Sabina A.; Pittet, Mikael J.; Lin, Charles P.; Dutta, Partha; Courties, Gabriel P; Wei, Ying; Gorbatov, Rostic; Majmudar, Maulik D; Stone, James Robert; Morrow, David Andrew; Sabatine, Marc Steven; Vinegoni, Claudio; Moskowitz, Michael Arthur; Libby, Peter; Swirski, Filip K.; Weissleder, Ralph; Nahrendorf, Matthias (Nature Publishing Group, 2012)
      During progression of atherosclerosis, myeloid cells destabilize lipid-rich plaque in the arterial wall and cause its rupture, thus triggering myocardial infarction and stroke. Survivors of acute coronary syndromes have a ...

    • Traditional Risk Factors Versus Biomarkers for Prediction of Secondary Events in Patients With Stable Coronary Heart Disease: From the Heart and Soul Study 

      Beatty, Alexis L; Ku, Ivy A; Bibbins-Domingo, Kirsten; Christenson, Robert H; DeFilippi, Christopher R; Ganz, Peter; Ix, Joachim H; Lloyd-Jones, Donald; Omland, Torbjørn; Sabatine, Marc S; Schiller, Nelson B; Shlipak, Michael G; Skali, Hicham; Takeuchi, Madoka; Vittinghoff, Eric; Whooley, Mary A (John Wiley & Sons, Ltd, 2015)
      Background: Patients with stable coronary heart disease (CHD) have widely varying prognoses and treatment options. Validated models for risk stratification of patients with CHD are needed. We sought to evaluate traditional ...