Now showing items 1-2 of 2

    • Ubiquitin Recognition by the Proteasome 

      Shi, Yuan (2014-10-21)
      Ubiquitin proteasome pathway is an important cellular pathway that affects the fate of almost all intracellular proteins. Misregulation of this pathway has been found to be associated with a broad range of human diseases, ...
    • USP14 deubiquitinates proteasome-bound substrates that are ubiquitinated at multiple sites 

      Lee, Byung-Hoon; Lu, Ying; Prado, Miguel A.; Shi, Yuan; Tian, Geng; Sun, Shuangwu; Elsasser, Suzanne; Gygi, Steven P.; King, Randall W.; Finley, Daniel J. (Springer Nature, 2016)
      USP14 is a major regulator of the proteasome and one of three proteasome-associated deubiquitinating enzymes1-9. Its effects on protein turnover are substrate specific, for unknown reasons. We report that USP14 shows a ...