Browsing by Author "Ford, Christopher Burton"
Now showing items 1-4 of 4
-
Distinct Effects on Diversifying Selection by Two Mechanisms of Immunity Against Streptococcus pneumoniae
Li, Yuan; Gierahn, Todd; Thompson, Claudette M.; Trzciński, Krzysztof; Ford, Christopher Burton; Croucher, Nicholas Jason; Gouveia, Paulo; Flechtner, Jessica B.; Malley, Richard; Lipsitch, Marc (Public Library of Science, 2012)Antigenic variation to evade host immunity has long been assumed to be a driving force of diversifying selection in pathogens. Colonization by Streptococcus pneumoniae, which is central to the organism's transmission and ... -
The Evolution of Drug Resistant Mycobacterium Tuberculosis
Ford, Christopher Burton (2012-10-29)Mycobacterium tuberculosis (Mtb) poses a global health catastrophe that has been compounded by the emergence of highly drug resistant Mtb strains. We used whole genome sequencing (WGS) to directly compare the accumulation ... -
The mutation rate of mycobacterial repetitive unit loci in strains of M. tuberculosis from cynomolgus macaque infection
Ragheb, Mark N; Ford, Christopher Burton; Chase, Michael Richard; Lin, Philana Ling; Flynn, JoAnne L; Fortune, Sarah Merritt (BioMed Central, 2013)Background: Mycobacterial interspersed repetitive units (MIRUs) are minisatellites within the Mycobacterium tuberculosis (Mtb) genome. Copy number variation (CNV) in MIRU loci is used for epidemiological typing, making the ... -
Mycobacterium tuberculosis mutation rate estimates from different lineages predict substantial differences in the emergence of drug resistant tuberculosis
Ford, Christopher B.; Shah, Rupal R.; Maeda, Midori Kato; Gagneux, Sebastien; Murray, Megan B.; Cohen, Ted; Johnston, James C.; Gardy, Jennifer; Lipsitch, Marc; Fortune, Sarah M. (2013)A critical question in tuberculosis control is why some strains of Mycobacterium tuberculosis are preferentially associated with multiple drug resistances. We demonstrate that M. tuberculosis strains from Lineage 2 (East ...