Now showing items 1-10 of 10

    • Antifungal Chemical Compounds Identified Using a C. elegans Pathogenicity Assay 

      Breger, Julia; Fuchs, Beth Burgwyn; Aperis, George; Moy, Terence I; Ausubel, Frederick M.; Mylonakis, Eleftherios; Cormack, Brendan P (Public Library of Science, 2007)
      There is an urgent need for the development of new antifungal agents. A facile in vivo model that evaluates libraries of chemical compounds could solve some of the main obstacles in current antifungal discovery. We show ...
    • Concepts and Principles of Photodynamic Therapy as an Alternative Antifungal Discovery Platform 

      Dai, Tianhong; Fuchs, Beth B.; Coleman, Jeffrey James; Prates, Renato A.; Astrakas, Christos; St. Denis, Tyler G.; Ribeiro, Martha S.; Mylonakis, Eleftherios; Hamblin, Michael; Tegos, George (Frontiers Research Foundation, 2012)
      Opportunistic fungal pathogens may cause superficial or serious invasive infections, especially in immunocompromised and debilitated patients. Invasive mycoses represent an exponentially growing threat for human health due ...
    • Contribution of Gelatinase, Serine Protease, and fsr to the Pathogenesis of Enterococcus faecalis Endophthalmitis 

      Engelbert, M.; Mylonakis, E; Ausubel, Frederick M.; Calderwood, Stephen Beaven; Gilmore, Michael S. (American Society for Microbiology, 2004)
      Gelatinase and serine protease were found to contribute in concert to pathogenesis in a rabbit model of endophthalmitis. However, a mutant defective in the fsr regulator was observed to be more attenuated than a mutant ...
    • Evolutionarily Conserved Recognition and Innate Immunity to Fungal Pathogens by the Scavenger Receptors SCARF1 and CD36 

      Tampakakis, Emmanouil; Puckett, Lindsay; Tai, Melissa F.; Stewart, Cameron R.; Hickman, Suzanne E.; Moore, Kathryn J.; El Khoury, Joseph; Means, Terry K.; Mylonakis, Eleftherios; Colvin, Richard Anthony; Seung, Edward N.; Pukkila-Worley, Read; Calderwood, Stephen Beaven; Hacohen, Nir; Luster, Andrew David (Rockefeller University Press, 2009)
      Receptors involved in innate immunity to fungal pathogens have not been fully elucidated. We show that the Caenorhabditis elegans receptors CED-1 and C03F11.3, and their mammalian orthologues, the scavenger receptors SCARF1 ...
    • Identification of Antifungal Compounds Active against Candida albicans Using an Improved High-Throughput Caenorhabditis elegans Assay 

      Okoli, Ikechukwu; Tempakakis, Emmanouil; Holson, Edward; Wagner, Florence; Conery, Annie L.; Larkins-Ford, Jonah; Stern, Andy; Coleman, Jeffrey James; An, W. Frank; Wu, Gang; Ausubel, Frederick M.; Mylonakis, Eleftherios (Public Library of Science, 2009)
      Candida albicans, the most common human pathogenic fungus, can establish a persistent lethal infection in the intestine of the microscopic nematode Caenorhabditis elegans. The C. elegans–C. albicans infection model was ...
    • The Impact of Antimicrobial Resistance and Aging in VAP Outcomes: Experience from a Large Tertiary Care Center 

      Arvanitis, Marios; Anagnostou, Theodora; Kourkoumpetis, Themistoklis K.; Ziakas, Panayiotis D.; Desalermos, Athanasios; Mylonakis, Eleftherios (Public Library of Science, 2014)
      Background: Ventilator associated pneumonia (VAP) is a serious infection among patients in the intensive care unit (ICU). Methods: We reviewed the medical charts of all patients admitted to the adult intensive care units ...
    • Photodynamic and Antibiotic Therapy Impair the Pathogenesis of Enterococcus faecium in a Whole Animal Insect Model 

      Chibebe, José, Jr.; Fuchs, Beth B.; Sabino, Caetano P.; Junqueira, Juliana C.; Jorge, Antonio O. C.; Ribeiro, Martha S.; Rice, Louis B.; Gilmore, Michael S.; Tegos, George; Hamblin, Michael; Mylonakis, Eleftherios (Public Library of Science, 2013)
      Enterococcus faecium has emerged as one of the most important pathogens in healthcare-associated infections worldwide due to its intrinsic and acquired resistance to many antibiotics, including vancomycin. Antimicrobial ...
    • The Role of Candida albicans SPT20 in Filamentation, Biofilm Formation and Pathogenesis 

      Tan, Xiaojiang; Fuchs, Beth Burgwyn; Wang, Yan; Chen, Weiping; J. Yuen, Grace; Chen, Rosalyn B.; Jayamani, Elamparithi; Anastassopoulou, Cleo; Pukkila-Worley, Read; Coleman, Jeffrey J.; Mylonakis, Eleftherios (Public Library of Science, 2014)
      Candida albicans is a ubiquitous fungus, which can cause very serious and sometimes life-threatening infections in susceptible patients. We used Caenorhabditis elegans as a model host to screen a library of C. albicans ...
    • Selecting an Invertebrate Model Host for the Study of Fungal Pathogenesis 

      Desalermos, Athanasios; Fuchs, Beth Burgwyn; Mylonakis, Eleftherios (Public Library of Science, 2012)
    • Whole Animal Automated Platform for Drug Discovery against Multi-Drug Resistant Staphylococcus aureus 

      Rajamuthiah, Rajmohan; Fuchs, Beth Burgwyn; Jayamani, Elamparithi; Kim, Younghoon; Larkins-Ford, Jonah; Conery, Annie; Ausubel, Frederick M.; Mylonakis, Eleftherios (Public Library of Science, 2014)
      Staphylococcus aureus, the leading cause of hospital-acquired infections in the United States, is also pathogenic to the model nematode Caenorhabditis elegans. The C. elegans-S. aureus infection model was previously carried ...