Now showing items 1-11 of 11

    • Class II MHC Self-Antigen Presentation in Human B and T Lymphocytes 

      Costantino, Cristina Maria; Spooner, Eric; Ploegh, Hidde L.; Hafler, David A. (Public Library of Science, 2012)
      Human CD4\(^+\) T cells process and present functional class II MHC-peptide complexes, but the endogenous peptide repertoire of these non-classical antigen presenting cells remains unknown. We eluted and sequenced HLA-DR-bound ...
    • Comprehensive Phenotyping in Multiple Sclerosis: Discovery Based Proteomics and the Current Understanding of Putative Biomarkers 

      O’Connor, Kevin C.; Roy, Sushmita Mimi; Becker, Christopher H.; Hafler, David A.; Kantor, Aaron B. (IOS Press, 2006)
      Currently, there is no single test for multiple sclerosis (MS). Diagnosis is confirmed through clinical evaluation, abnormalities revealed by magnetic resonance imaging (MRI), and analysis of cerebrospinal fluid (CSF) ...
    • Fine-Mapping the Genetic Association of the Major Histocompatibility Complex in Multiple Sclerosis: HLA and Non-HLA Effects 

      Patsopoulos, Nikolaos A.; Barcellos, Lisa F.; Hintzen, Rogier Q.; Schaefer, Catherine; van Duijn, Cornelia M.; Noble, Janelle A.; Raj, Towfique; Gourraud, Pierre-Antoine; Stranger, Barbara E.; Oksenberg, Jorge; Olsson, Tomas; Taylor, Bruce V.; Sawcer, Stephen; Hafler, David A.; Carrington, Mary; De Jager, Philip L.; de Bakker, Paul I. W. (Public Library of Science, 2013)
      The major histocompatibility complex (MHC) region is strongly associated with multiple sclerosis (MS) susceptibility. HLA-DRB1*15:01 has the strongest effect, and several other alleles have been reported at different levels ...
    • Genetic Analysis of Human Traits In Vitro: Drug Response and Gene Expression in Lymphoblastoid Cell Lines 

      Yelensky, Roman; Bonakdar, Sasha; Wolfish, Cara S.; Cotsapas, Chris; Rivas, Manuel; Dermitzakis, Emmanouil T.; Choy, Edwin; Plenge, Robert M.; Saxena, Richa; De Jager, Philip Lawrence; Shaw, Stanley Yang; Slavik, Jacqueline Marie; Cahir-McFarland, Ellen D.; Kieff, Elliott D.; Hafler, David A.; Daly, Mark Joseph; Altshuler, David Matthew (Public Library of Science, 2008)
      Lymphoblastoid cell lines (LCLs), originally collected as renewable sources of DNA, are now being used as a model system to study genotype–phenotype relationships in human cells, including searches for QTLs influencing ...
    • Genetic and Epigenetic Fine-Mapping of Causal Autoimmune Disease Variants 

      Farh, Kyle Kai-How; Marson, Alexander; Zhu, Jiang; Kleinewietfeld, Markus; Housley, William J.; Beik, Samantha; Shoresh, Noam; Whitton, Holly; Ryan, Russell J.H.; Shishkin, Alexander A.; Hatan, Meital; Carrasco-Alfonso, Marlene J.; Mayer, Dita; Luckey, C. John; Patsopoulos, Nikolaos A.; De Jager, Philip L.; Kuchroo, Vijay K.; Epstein, Charles B; Daly, Mark J.; Hafler, David A.; Bernstein, Bradley E. (2014)
      Summary Genome-wide association studies have identified loci underlying human diseases, but the causal nucleotide changes and mechanisms remain largely unknown. Here we developed a fine-mapping algorithm to identify candidate ...
    • IL2RA Genetic Heterogeneity in Multiple Sclerosis and Type 1 Diabetes Susceptibility and Soluble Interleukin-2 Receptor Production 

      Maier, Lisa M.; Lowe, Christopher E.; Downes, Kate; Clark, Pamela M.; Walker, Neil; Aubin, Cristin; Oksenberg, Jorge R.; Hauser, Stephen L.; Compston, Alistair; Sawcer, Stephen; Wicker, Linda S.; Cooper, Jason S; Anderson, David E.; Severson, Christopher; Healy, Brian Curran; The International Multiple Sclerosis Genetics Consortium; De Jager, Philip Lawrence; Todd, John A.; Hafler, David A. (Public Library of Science, 2009)
      Multiple sclerosis (MS) and type 1 diabetes (T1D) are organ-specific autoimmune disorders with significant heritability, part of which is conferred by shared alleles. For decades, the Human Leukocyte Antigen (HLA) complex ...
    • Induction and molecular signature of pathogenic TH17 cells 

      Lee, Youjin; Awasthi, Amit; Yosef, Nir; Quintana, Francisco Javier; Xiao, Sheng; Peters, Anneli; Wu, Chuan; Kleinewietfeld, Markus; Kunder, Sharon R.; Hafler, David A.; Sobel, Raymond A.; Regev, Aviv; Kuchroo, Vijay Kumar (2012)
      Interleukin 17 (IL-17)-producing TH17 cells are often present at the sites of tissue inflammation in autoimmune diseases, which has lead to the conclusion that TH17 are main drivers of autoimmune tissue injury. However, ...
    • A Major Histocompatibility Class I Locus Contributes to Multiple Sclerosis Susceptibility Independently from HLA-DRB1*15:01 

      Cree, Bruce A. C.; Rioux, John D.; McCauley, Jacob L.; Gourraud, Pierre-Antoine F. D.; Goyette, Philippe; Santaniello, Adam; Vyse, Timothy J.; Gregersen, Peter K.; Mirel, Daniel; Haines, Jonathan L.; Pericak-Vance, Margaret A.; Compston, Alastair; Sawcer, Stephen J.; Oksenberg, Jorge R.; Hauser, Stephen L.; Kleinschnitz, Christoph; McElroy, Joseph; De Jager, Philip Lawrence; Hafler, David A. (Public Library of Science, 2010)
      Background: In Northern European descended populations, genetic susceptibility for multiple sclerosis (MS) is associated with alleles of the human leukocyte antigen (HLA) Class II gene DRB1. Whether other major histocompatibility ...
    • Microbial Reprogramming Inhibits Western Diet-Associated Obesity 

      Poutahidis, Theofilos; Kleinewietfeld, Markus; Smillie, Christopher; Levkovich, Tatiana; Perrotta, Alison; Bhela, Siddheshvar; Varian, Bernard J.; Ibrahim, Yassin M.; Lakritz, Jessica R.; Kearney, Sean M.; Chatzigiagkos, Antonis; Hafler, David A.; Alm, Eric J.; Erdman, Susan E. (Public Library of Science, 2013)
      A recent epidemiological study showed that eating ‘fast food’ items such as potato chips increased likelihood of obesity, whereas eating yogurt prevented age-associated weight gain in humans. It was demonstrated previously ...
    • Modeling the Cumulative Genetic Risk for Multiple Sclerosis from Genome-Wide Association Data 

      Wang, Joanne H; Pappas, Derek; Pelletier, Daniel; Kappos, Ludwig; Polman, Chris H; Matthews, Paul M; Hauser, Stephen L; Baranzini, Sergio E; Oksenberg, Jorge R; De Jager, Philip Lawrence; de Bakker, Paul I Wen; Chibnik, Lori; Hafler, David A. (BioMed Central, 2011)
      Background: Multiple sclerosis (MS) is the most common cause of chronic neurologic disability beginning in early to middle adult life. Results from recent genome-wide association studies (GWAS) have substantially lengthened ...
    • A Second Major Histocompatibility Complex Susceptibility Locus for Multiple Sclerosis 

      Yeo, Tai Wai; Gregory, Simon G; Barcellos, Lisa F; Walton, Amie; Goris, An; Fenoglio, Chiara; Ban, Maria; Taylor, Craig J; Goodman, Reyna S; Walsh, Emily; Wolfish, Cara S; Horton, Roger; Traherne, James; Beck, Stephan; Trowsdale, John; Caillier, Stacy J; Green, Todd; Pobywajlo, Susan; Pericak-Vance, Margaret A; Haines, Jonathan L; Oksenberg, Jorge R; Hauser, Stephen L; Compston, Alastair; Rioux, John D; Sawcer, Stephen; De Jager, Philip Lawrence; Ivinson, Adrian J.; Lander, Eric Steven; Daly, Mark Joseph; Hafler, David A. (Wiley Subscription Services, Inc., A Wiley Company, 2007)
      Objective: Variation in the major histocompatibility complex (MHC) on chromosome 6p21 is known to influence susceptibility to multiple sclerosis with the strongest effect originating from the HLA-DRB1 gene in the class II ...