Now showing items 1-7 of 7

    • Circulating Mitochondrial DNA in Patients in the ICU as a Marker of Mortality: Derivation and Validation 

      Nakahira, Kiichi; Kyung, Sun-Young; Rogers, Angela J.; Gazourian, Lee; Youn, Sojung; Massaro, Anthony F.; Quintana, Carolina; Osorio, Juan C.; Wang, Zhaoxi; Zhao, Yang; Lawler, Laurie A.; Christie, Jason D.; Meyer, Nuala J.; Causland, Finnian R. Mc.; Waikar, Sushrut S.; Waxman, Aaron B.; Chung, Raymond T.; Bueno, Raphael; Rosas, Ivan O.; Fredenburgh, Laura E.; Baron, Rebecca M.; Christiani, David C.; Hunninghake, Gary M.; Choi, Augustine M. K. (Public Library of Science, 2013)
      Background: Mitochondrial DNA (mtDNA) is a critical activator of inflammation and the innate immune system. However, mtDNA level has not been tested for its role as a biomarker in the intensive care unit (ICU). We hypothesized ...
    • Genetic and hypoxic alterations of the microRNA-210-ISCU1/2 axis promote iron–sulfur deficiency and pulmonary hypertension 

      White, Kevin; Lu, Yu; Annis, Sofia; Hale, Andrew E; Chau, B Nelson; Dahlman, James E; Hemann, Craig; Opotowsky, Alexander R; Vargas, Sara O; Rosas, Ivan; Perrella, Mark A; Osorio, Juan C; Haley, Kathleen J; Graham, Brian B; Kumar, Rahul; Saggar, Rajan; Saggar, Rajeev; Wallace, W Dean; Ross, David J; Khan, Omar F; Bader, Andrew; Gochuico, Bernadette R; Matar, Majed; Polach, Kevin; Johannessen, Nicolai M; Prosser, Haydn M; Anderson, Daniel G; Langer, Robert; Zweier, Jay L; Bindoff, Laurence A; Systrom, David; Waxman, Aaron B; Jin, Richard C; Chan, Stephen Y (BlackWell Publishing Ltd, 2015)
      Iron–sulfur (Fe-S) clusters are essential for mitochondrial metabolism, but their regulation in pulmonary hypertension (PH) remains enigmatic. We demonstrate that alterations of the miR-210-ISCU1/2 axis cause Fe-S deficiencies ...
    • Improving Decision Making for Massive Transfusions in a Resource Poor Setting: A Preliminary Study in Kenya 

      Riviello, Elisabeth D.; Letchford, Stephen; Cook, Earl Francis; Waxman, Aaron B.; Gaziano, Thomas (Public Library of Science, 2015)
      Background: The reality of finite resources has a real-world impact on a patient’s ability to receive life-saving care in resource-poor settings. Blood for transfusion is an example of a scarce resource. Very few studies ...
    • Plasma Gelsolin Depletion and Circulating Actin in Sepsis—A Pilot Study 

      Lee, Po-Shun; Patel, Sanjay R; Christiani, David C.; Bajwa, Ednan Khalid; Stossel, Thomas Peter; Waxman, Aaron Bradley (Public Library of Science, 2008)
      Background: Depletion of the circulating actin-binding protein, plasma gelsolin (pGSN) has been described in septic patients and animals. We hypothesized that the extent of pGSN reduction correlates with outcomes of septic ...
    • A Review of Sitaxsentan Sodium in Patients with Pulmonary Arterial Hypertension 

      Waxman, Aaron Bradley (Dove Medical Press, 2007)
      Pulmonary arterial hypertension (PAH) is a life threatening, progressive condition which eventually leads to fatal right heart failure. Endothelin-1 (ET-1), a potent vasoconstrictor peptide, is increased in the pulmonary ...
    • Right heart failure: toward a common language 

      Mehra, Mandeep R.; Park, Myung H.; Landzberg, Michael J.; Lala, Anuradha; Waxman, Aaron B. (University of Chicago Press, 2013)
      Abstract In this guideline, the International Right Heart Foundation Working Group moves a step forward to develop a common language to describe the development and defects that exemplify the common syndrome of right heart ...
    • Roundtable Debate: Controversies in the Management of the Septic Patient – Desperately Seeking Consensus 

      Waxman, Aaron Bradley; Ward, Nicholas; Thompson, Taylor; Lilly, Craig M.; Lisbon, Alan; Hill, Nicholas Edward; Nasraway, Stanley A.; Heard, Stephen; Corwin, Howard; Levy, Mitchell (BioMed Central, 2005)
      Despite continuous advances in technologic and pharmacologic management, the mortality rate from septic shock remains high. Care of patients with sepsis includes measures to support the circulatory system and treat the ...