Now showing items 1-10 of 10

    • Adiponectin, Leptin, and Resistin in Asthma: Basic Mechanisms through Population Studies 

      Sood, Akshay; Shore, Stephanie A. (Hindawi Publishing Corporation, 2013)
      Adipokines, factors produced by adipose tissue, may be proinflammatory (such as leptin and resistin) or anti-inflammatory (such as adiponectin). Effects of these adipokines on the lungs have the potential to evoke or ...
    • Augmented Pulmonary Responses to Acute Ozone Exposure in Obese Mice: Roles of TNFR2 and IL-13 

      Williams, Alison Suzanne; Mathews, Joel Andrew; Kasahara, David Itiro; Chen, Lucas; Wurmbrand, Allison Patricia; Si, Huiqing; Shore, Stephanie Ann (National Institute of Environmental Health Sciences, 2013)
      Background: Acute ozone (O3) exposure results in greater inflammation and airway hyperresponsiveness (AHR) in obese versus lean mice. Objectives: We examined the hypothesis that these augmented responses to O3 are the ...
    • IL-17 producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity 

      Kim, Hye Young; Lee, Hyun Jun; Chang, Ya-Jen; Pichavant, Muriel; Shore, Stephanie A.; Fitzgerald, Katherine A.; Iwakura, Yoichiro; Israel, Elliot; Bolger, Kenneth; Faul, John; DeKruyff, Rosemarie H.; Umetsu, Dale T. (2014)
      Obesity is associated with the development of asthma and considerable asthma-related healthcare utilization. To understand the immunological pathways that lead to obesity-associated asthma, we fed mice a high fat diet for ...
    • Impact of Adiponectin Overexpression on Allergic Airways Responses in Mice 

      Verbout, Norah G.; Benedito, Leandro; Williams, Alison S.; Kasahara, David I.; Wurmbrand, Allison P.; Si, Huiqing; Halayko, Andrew J.; Hug, Christopher; Shore, Stephanie A. (Hindawi Publishing Corporation, 2013)
      Obesity is an important risk factor for asthma. Obese individuals have decreased circulating adiponectin, an adipose-derived hormone with anti-inflammatory properties. We hypothesized that transgenic overexpression of ...
    • Induction of IL-17A Precedes Development of Airway Hyperresponsiveness during Diet-Induced Obesity and Correlates with Complement Factor D 

      Mathews, Joel A.; Wurmbrand, Allison P.; Ribeiro, Luiza; Neto, Felippe Lazar; Shore, Stephanie A. (Frontiers Media S.A., 2014)
      Obesity is a risk factor for the development of asthma. Obese mice exhibit innate airway hyperresponsiveness (AHR), a characteristic feature of asthma, and IL-17A is required for development of AHR in obese mice. The purpose ...
    • Role of the Adiponectin Binding Protein, T-Cadherin (Cdh13), in Allergic Airways Responses in Mice 

      Williams, Alison S.; Kasahara, David I.; Verbout, Norah G.; Fedulov, Alexey V.; Zhu, Ming; Si, Huiqing; Wurmbrand, Allison Patricia; Hug, Christopher; Ranscht, Barbara; Shore, Stephanie Ann (Public Library of Science, 2012)
      Adiponectin is an adipose derived hormone that declines in obesity. We have previously shown that exogenous administration of adiponectin reduces allergic airways responses in mice. T-cadherin (T-cad; Cdh13) is a binding ...
    • Role of the Adiponectin Binding Protein, T-Cadherin (cdh13), in Pulmonary Responses to Subacute Ozone 

      Kasahara, David I.; Williams, Alison S.; Benedito, Leandro A.; Ranscht, Barbara; Kobzik, Lester; Hug, Christopher; Shore, Stephanie A. (Public Library of Science, 2013)
      Adiponectin, an adipose derived hormone with pleiotropic functions, binds to several proteins, including T-cadherin. We have previously reported that adiponectin deficient (Adipo−/−) mice have increased IL-17A-dependent ...
    • Unjamming and cell shape in the asthmatic airway epithelium 

      Park, Jin-Ah; Kim, Jae Hun; Bi, Dapeng; Mitchel, Jennifer; Qazvini, Nader Taheri; Tantisira, Kelan; Park, Chan Young Young; McGill, Maureen P; Kim, Sae-Hoon; Gweon, Bomi; Notbohm, Jacob K; Steward Jr, Robert; Burger, Stephanie; Randell, Scott H.; Kho, Alvin Thong-Juak; Tambe, Dhananjay; Hardin, Corey; Shore, Stephanie Ann; Israel, Elliot; Weitz, David A.; Tschumperlin, Daniel; Henske, Elizabeth Petri; Weiss, Scott Tillman; Manning, Mary Ellen; Butler, James P.; Drazen, Jeffrey Mark; Fredberg, Jeffrey J. (Nature Publishing Group, 2015)
      From coffee beans flowing in a chute to cells remodelling in a living tissue, a wide variety of close-packed collective systems— both inert and living—have the potential to jam. The collective can sometimes flow like a ...
    • γδ T Cells Are Required for M2 Macrophage Polarization and Resolution of Ozone-Induced Pulmonary Inflammation in Mice 

      Mathews, Joel A.; Kasahara, David I.; Ribeiro, Luiza; Wurmbrand, Allison P.; Ninin, Fernanda M. C.; Shore, Stephanie A. (Public Library of Science, 2015)
      We examined the role of γδ T cells in the induction of alternatively activated M2 macrophages and the resolution of inflammation after ozone exposure. Wildtype (WT) mice and mice deficient in γδ T cells (TCRδ-/- mice) were ...
    • γδ T Cells Are Required for Pulmonary IL-17A Expression after Ozone Exposure in Mice: Role of TNFα 

      Mathews, Joel A.; Williams, Alison S.; Brand, Jeffrey D.; Wurmbrand, Allison P.; Chen, Lucas; Ninin, Fernanda MC.; Si, Huiqing; Kasahara, David I.; Shore, Stephanie A. (Public Library of Science, 2014)
      Ozone is an air pollutant that causes pulmonary symptoms. In mice, ozone exposure causes pulmonary injury and increases bronchoalveolar lavage macrophages and neutrophils. We have shown that IL-17A is important in the ...