Now showing items 1-7 of 7

    • Accelerating Markov chain Monte Carlo via parallel predictive prefetching 

      Angelino, Elaine Lee (2014-10-21)
      We present a general framework for accelerating a large class of widely used Markov chain Monte Carlo (MCMC) algorithms. This dissertation demonstrates that MCMC inference can be accelerated in a model of parallel computation ...
    • A Composite of Multiple Signals Distinguishes Causal Variants in Regions of Positive Selection 

      Shylakhter, Ilya; Karlsson, Elinor Kathryn; Byrne, Elizabeth Hockfield; Morales, Shannon; Frieden, Gabriel; Hostetter, Elizabeth; Angelino, Elaine Lee; Garber, Manuel; Zuk, Or; Lander, Eric Steven; Schaffner, Stephen; Sabeti, Pardis Christine; Grossman, Sharon Rachel (American Association for Advancement of Science, 2010)
      The human genome contains hundreds of regions whose patterns of genetic variation indicate recent positive natural selection, yet for most the underlying gene and the advantageous mutation remain unknown. We developed a ...
    • Computational Caches 

      Waterland, Amos; Angelino, Elaine Lee; Cubuk, Ekin Dogus; Kaxiras, Efthimios; Adams, Ryan Prescott; Appavoo, Jonathan; Seltzer, Margo I. (ACM Press, 2013)
      Caching is a well-known technique for speeding up computation. We cache data from file systems and databases; we cache dynamically generated code blocks; we cache page translations in TLBs. We propose to cache the act of ...
    • Flash Caching on the Storage Client 

      Holland, David A.; Angelino, Elaine Lee; Wald, Gideon; Seltzer, Margo I. (USENIX Association, 2013)
      Flash memory has recently become popular as a caching medium. Most uses to date are on the storage server side. We investigate a different structure: flash as a cache on the client side of a networked storage environment. ...
    • Identification and Functional Validation of the Novel Antimalarial Resistance Locus PF10_0355 in Plasmodium falciparum 

      Van Tyne, Daria Natalie; Park, Daniel John; Schaffner, Stephen; Neafsey, Daniel Edward; Angelino, Elaine Lee; Cortese, Joseph F.; Barnes, Kayla G.; Rosen, David M.; Lukens, Amanda Kathleen; Daniels, Rachel Fath; Milner, Danny Arnold; Johnson, Charles A.; Shlyakhter, Ilya; Grossman, Sharon Rachel; Becker, Justin S.; Yamins, Daniel Louis Kanef; Karlsson, Elinor Kathryn; Ndiaye, Daouda; Sarr, Ousmane; Mboup, Souleymane; Happi, Christian Tientcha; Furlotte, Nicholas A.; Eskin, Eleazar; Kang, Hyun Min; Hartl, Daniel L.; Birren, Bruce W.; Wiegand, Roger C.; Lander, Eric Steven; Wirth, Dyann Fergus; Cooke, Sarah Volkman; Sabeti, Pardis Christine (Public Library of Science, 2011)
      The Plasmodium falciparum parasite's ability to adapt to environmental pressures, such as the human immune system and antimalarial drugs, makes malaria an enduring burden to public health. Understanding the genetic basis ...
    • Provenance Integration Requires Reconciliation 

      Angelino, Elaine Lee; Braun, Uri Jacob; Holland, David A; Macko, Peter; Margo, Daniel Wyatt; Seltzer, Margo I. (2011)
      While there has been a great deal of research on provenance systems, there has been little discussion about challenges that arise when making different provenance systems interoperate. In fact, most of the literature focuses ...
    • StarFlow: A Script-Centric Data Analysis Environment 

      Angelino, Elaine Lee; Yamins, Daniel Louis Kanef; Seltzer, Margo I. (Springer, 2010)
      We introduce StarFlow, a script-centric environment for data analysis. StarFlow has four main features: (1) extraction of control and data-flow dependencies through a novel combination of static analysis, dynamic runtime ...