Now showing items 1-20 of 24

    • 5-Fluorouracil upregulates cell surface B7-H1 (PD-L1) expression in gastrointestinal cancers 

      Van Der Kraak, Lauren; Goel, Gaurav; Ramanan, Krishnaveni; Kaltenmeier, Christof; Zhang, Lin; Normolle, Daniel P.; Freeman, Gordon J.; Tang, Daolin; Nason, Katie S.; Davison, Jon M.; Luketich, James D.; Dhupar, Rajeev; Lotze, Michael T. (BioMed Central, 2016)
      Background: Resistance to chemotherapy is a major obstacle in the effective treatment of cancer patients. B7-homolog 1, also known as programmed death ligand-1 (PD-L1), is an immunoregulatory protein that is overexpressed ...
    • Activation of the PD-1 Pathway Contributes to Immune Escape in EGFR-Driven Lung Tumors 

      Akbay, E; Koyama, S.; Carretero, J.; Altabef, A.; Tchaicha, J. H.; Christensen, Camilla Laulund; Mikse, O. R.; Cherniack, Andrew David; Beauchamp, Ellen Monica; Pugh, T; Wilkerson, M. D.; Fecci, P; Butaney, M.; Reibel, J. B.; Soucheray, M.; Cohoon, T. J.; Janne, Pasi Antero; Meyerson, Matthew Langer; Hayes, D. N.; Shapiro, Geoffrey Ira; Shimamura, T; Sholl, Lynette Marie; Rodig, Scott J.; Freeman, Gordon James; Hammerman, Peter Seth; Dranoff, G; Wong, Kwok-Kin (American Association for Cancer Research (AACR), 2013)
      The success in lung cancer therapy with Programmed Death (PD)-1 blockade suggests that immune escape mechanisms contribute to lung tumor pathogenesis. We identified a correlation between Epidermal Growth Factor Receptor ...
    • Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints 

      Koyama, Shohei; Akbay, Esra A.; Li, Yvonne Y.; Herter-Sprie, Grit S.; Buczkowski, Kevin A.; Richards, William G.; Gandhi, Leena; Redig, Amanda J.; Rodig, Scott J.; Asahina, Hajime; Jones, Robert E.; Kulkarni, Meghana M.; Kuraguchi, Mari; Palakurthi, Sangeetha; Fecci, Peter E.; Johnson, Bruce E.; Janne, Pasi A.; Engelman, Jeffrey A.; Gangadharan, Sidharta P.; Costa, Daniel B.; Freeman, Gordon J.; Bueno, Raphael; Hodi, F. Stephen; Dranoff, Glenn; Wong, Kwok-Kin; Hammerman, Peter S. (Nature Publishing Group, 2016)
      Despite compelling antitumour activity of antibodies targeting the programmed death 1 (PD-1): programmed death ligand 1 (PD-L1) immune checkpoint in lung cancer, resistance to these therapies has increasingly been observed. ...
    • BTLA expression declines on B cells of the aged and is associated with low responsiveness to the trivalent influenza vaccine 

      Kannan, Senthil; Kurupati, Raj K.; Doyle, Susan A.; Freeman, Gordon J.; Schmader, Kenneth E.; Ertl, Hildegund C.J. (Impact Journals LLC, 2015)
      Virus-neutralizing antibody and B cell responses to influenza A viruses were measured in 35 aged and 28 middle-aged individuals following vaccination with the 2012 and 2013 trivalent inactivated influenza vaccines. Antibody ...
    • CD160Ig Fusion Protein Targets a Novel Costimulatory Pathway and Prolongs Allograft Survival 

      D’Addio, Francesca; Ueno, Takuya; Clarkson, Michael; Zhu, Baogong; Vergani, Andrea; Freeman, Gordon James; Sayegh, Mohamed Hassan; Ansari, Mohammed Javeed I.; Fiorina, Paolo; Habicht, Antje (Public Library of Science, 2013)
      CD160 is a cell surface molecule expressed by most NK cells and approximately 50% of CD8+ cytotoxic T lymphocytes. Engagement of CD160 by MHC class-I directly triggers a costimulatory signal to TCR-induced proliferation, ...
    • CD40L-Tri, a novel formulation of recombinant human CD40L that effectively activates B cells 

      Naito, Masayasu; Hainz, Ursula; Burkhardt, Ute E.; Fu, Buyin; Ahove, Deborah; Stevenson, Kristen E.; Rajasagi, Mohini; Zhu, Baogong; Alonso, Anselmo; Witten, Elizabeth; Matsuoka, Ken-ichi; Neuberg, Donna; Duke-Cohan, Jonathan S.; Wu, Cathy Ju-Ying; Freeman, Gordon James (Springer-Verlag, 2012)
      CD40L has a well-established role in enhancing the immunostimulatory capacity of normal and malignant B cells, but a formulation suitable for clinical use has not been widely available. Like other TNF family members, in ...
    • Checkpoint Blockade Cancer Immunotherapy Targets Tumour-Specific Mutant Antigens 

      Gubin, Matthew M.; Zhang, Xiuli; Schuster, Heiko; Caron, Etienne; Ward, Jeffrey P.; Noguchi, Takuro; Ivanova, Yulia; Hundal, Jasreet; Arthur, Cora D.; Krebber, Willem-Jan; Mulder, Gwenn E.; Toebes, Mireille; Vesely, Matthew D.; Lam, Samuel S.K.; Korman, Alan J.; Allison, James P.; Freeman, Gordon J.; Sharpe, Arlene H.; Pearce, Erika L.; Schumacher, Ton N.; Aebersold, Ruedi; Rammensee, Hans-Georg; Melief, Cornelis J. M.; Mardis, Elaine R.; Gillanders, William E.; Artyomov, Maxim N.; Schreiber, Robert D. (2014)
      The immune system plays key roles in determining the fate of developing cancers by not only functioning as a tumour promoter facilitating cellular transformation, promoting tumour growth and sculpting tumour cell ...
    • Chimeric antigen receptor T cells secreting anti-PD-L1 antibodies more effectively regress renal cell carcinoma in a humanized mouse model 

      Suarez, Eloah Rabello; Chang, De-Kuan; Sun, Jiusong; Sui, Jianhua; Freeman, Gordon J.; Signoretti, Sabina; Zhu, Quan; Marasco, Wayne A. (Impact Journals LLC, 2016)
      Advances in the treatment of metastatic clear cell renal cell carcinoma (ccRCC) have led to improved progression-free survival of many patients; however the therapies are toxic, rarely achieve durable long-term complete ...
    • Combining BRAF inhibitor and anti PD-L1 antibody dramatically improves tumor regression and anti tumor immunity in an immunocompetent murine model of anaplastic thyroid cancer 

      Brauner, Eran; Gunda, Viswanath; Borre, Pierre Vanden; Zurakowski, David; Kim, Yon Seon; Dennett, Kate Virginia; Amin, Salma; Freeman, Gordon James; Parangi, Sareh (Impact Journals LLC, 2016)
      The interaction of programmed cell death-1 and its ligand is widely studied in cancer. Monoclonal antibodies blocking these molecules have had great success but little is known about them in thyroid cancer. We investigated ...
    • Correlation of Apobec Mrna Expression with overall Survival and pd-l1 Expression in Urothelial Carcinoma 

      Mullane, Stephanie A.; Werner, Lillian; Rosenberg, Jonathan; Signoretti, Sabina; Callea, Marcella; Choueiri, Toni K.; Freeman, Gordon J.; Bellmunt, Joaquim (Nature Publishing Group, 2016)
      Metastatic urothelial carcinoma (mUC) has a very high mutational rate and is associated with an APOBEC mutation signature. We examined the correlation of APOBEC expression with overall survival (OS) and PD-L1 expression ...
    • Inclusion of CD80 in HSV Targets the Recombinant Virus to PD-L1 on DCs and Allows Productive Infection and Robust Immune Responses 

      Mott, Kevin R.; Allen, Sariah J.; Zandian, Mandana; Akbari, Omid; Hamrah, Pedram; Maazi, Hadi; Wechsler, Steven L.; Sharpe, Arlene H.; Freeman, Gordon J.; Ghiasi, Homayon (Public Library of Science, 2014)
      CD80 plays a critical role in stimulation of T cells and subsequent control of infection. To investigate the effect of CD80 on HSV-1 infection, we constructed a recombinant HSV-1 virus that expresses two copies of the CD80 ...
    • Increased expression of the immune modulatory molecule PD-L1 (CD274) in anaplastic meningioma 

      Du, Ziming; Abedalthagafi, Malak; Aizer, Ayal A.; McHenry, Allison R.; Sun, Heather H.; Bray, Mark-Anthony; Viramontes, Omar; Machaidze, Revaz; Brastianos, Priscilla K.; Reardon, David A.; Dunn, Ian F.; Freeman, Gordon J.; Ligon, Keith L.; Carpenter, Anne E.; Alexander, Brian M.; Agar, Nathalie Y.; Rodig, Scott J.; Bradshaw, Elizabeth M.; Santagata, Sandro (Impact Journals LLC, 2015)
      There are no effective medical treatments for WHO grade III (anaplastic) meningioma. Patients with this high-grade malignancy have a median survival of less than two years. Therapeutics that modulate the mechanisms that ...
    • Interferon-γ-induced activation of JAK1 and JAK2 suppresses tumor cell susceptibility to NK cells through upregulation of PD-L1 expression 

      Bellucci, Roberto; Martin, Allison; Bommarito, Davide; Wang, Kathy; Hansen, Steen H; Freeman, Gordon J; Ritz, Jerome (Taylor & Francis, 2015)
      Inhibition of JAK1 or JAK2 in human tumor cells was previously shown to increase susceptibility of these cells to NK cell lysis. In the present study, we examined the cellular mechanisms that mediate this effect in ...
    • Interplay between regulatory T cells and PD-1 in modulating T cell exhaustion and viral control during chronic LCMV infection 

      Penaloza-MacMaster, Pablo; Kamphorst, Alice O.; Wieland, Andreas; Araki, Koichi; Iyer, Smita S.; West, Erin E.; O’Mara, Leigh; Yang, Shu; Konieczny, Bogumila T.; Sharpe, Arlene H.; Freeman, Gordon J.; Rudensky, Alexander Y.; Ahmed, Rafi (The Rockefeller University Press, 2014)
      Regulatory T (T reg) cells are critical for preventing autoimmunity mediated by self-reactive T cells, but their role in modulating immune responses during chronic viral infection is not well defined. To address this ...
    • LLT1 and CD161 Expression in Human Germinal Centers Promotes B Cell Activation and CXCR4 Downregulation 

      Llibre, Alba; López-Macías, Constantino; Marafioti, Teresa; Mehta, Hema; Partridge, Amy; Kanzig, Carina; Rivellese, Felice; Galson, Jacob D.; Walker, Lucy J.; Milne, Paul; Phillips, Rodney E.; Kelly, Dominic F.; Freeman, Gordon J.; El Shikh, Mohey Eldin; Klenerman, Paul; Willberg, Christian B. (AAI, 2016)
      Germinal centers (GCs) are microanatomical structures critical for the development of high-affinity Abs and B cell memory. They are organized into two zones, light and dark, with coordinated roles, controlled by local ...
    • P16-08. Combined blockade of the PD-1 and IL-10 pathways synergistically enhance HIV-specific CD4 T cell functions 

      Porichis, Filippos; Kwon, DS; Tighe, DP; Pavlik, DF; Kavanagh, Daniel Garrett; Freeman, Gordon James; Walker, Bruce David; Kaufmann, Daniel (BioMed Central, 2009)
    • PD-1 Blockade in Chronically HIV-1-Infected Humanized Mice Suppresses Viral Loads 

      Seung, Edward; Dudek, Timothy E.; Allen, Todd M.; Freeman, Gordon J.; Luster, Andrew D.; Tager, Andrew M. (Public Library of Science, 2013)
      An estimated 34 million people are living with HIV worldwide (UNAIDS, 2012), with the number of infected persons rising every year. Increases in HIV prevalence have resulted not only from new infections, but also from ...
    • PD-1, IL-10, IFN-γ and IL-12 Form a Network to Regulate HIV-1-Specific CD4 T Cell and Antigen-Presenting Cell Function 

      Porichis, Filippos; Barblu, Lucie; Kwon, Douglas; Hart, M; Zupkosky, J; Freeman, Gordon James; Kavanagh, Daniel Garrett; Kaufmann, Daniel (BioMed Central, 2012)
    • PD-L1 Regulates the Development, Maintenance, and Function of Induced Regulatory T Cells 

      Francisco, Loise Marie; Salinas, Victor H.; Brown, Keturah Elise; Vanguri, Vijay K.; Freeman, Gordon James; Kuchroo, Vijay Kumar; Sharpe, Arlene Helen (The Rockefeller University Press, 2009)
      Both the programmed death (PD) 1–PD-ligand (PD-L) pathway and regulatory T (T reg) cells are instrumental to the maintenance of peripheral tolerance. We demonstrate that PD-L1 has a pivotal role in regulating induced T reg ...
    • Programmed death ligand-1 expression in adrenocortical carcinoma: an exploratory biomarker study 

      Fay, André P; Signoretti, Sabina; Callea, Marcella; Telό, Gabriela H; McKay, Rana R; Song, Jiaxi; Carvo, Ingrid; Lampron, Megan E; Kaymakcalan, Marina D; Poli-de-Figueiredo, Carlos E; Bellmunt, Joaquim; Hodi, F Stephen; Freeman, Gordon J; Elfiky, Aymen; Choueiri, Toni K (BioMed Central, 2015)
      Background: Adrenocortical carcinoma (ACC) is a rare tumor in which prognostic factors are still not well established. Programmed Death Ligand-1 (PD-L1) expression in ACC and its association with clinico-pathological ...