Now showing items 1-20 of 57

    • Advanced Signal Processing Methods for Biomedical Imaging 

      Ruiz-Alzola, Juan; Alberola-López, Carlos; Westin, Carl-Fredrik (Hindawi Publishing Corporation, 2013)
    • Anterior limb of the internal capsule in schizophrenia: a diffusion tensor tractography study 

      Rosenberger, Gudrun; Nestor, Paul Gerard; Oh, Jungsu S.; Levitt, James Jonathan; Kindleman, Gordon; Bouix, Sylvain; Fitzsimmons, Jennifer J; Niznikiewicz, Margaret A.; Westin, Carl-Fredrik; Kikinis, Ron; McCarley, Robert William; Shenton, Martha Elizabeth; Kubicki, Marek R. (Springer Science + Business Media, 2012)
      Thalamo-cortical feedback loops play a key role in the processing and coordination of processing and integration of perceptual inputs and outputs, and disruption in this connection has long been hypothesized to contribute ...
    • The Application of DTI to Investigate White Matter Abnormalities in Schizophrenia 

      Kubicki, Marek R.; Westin, Carl-Fredrik; McCarley, Robert William; Shenton, Martha Elizabeth (Wiley-Blackwell, 2005)
      Schizophrenia is a serious and disabling mental disorder that affects approximately 1% of the general population, with often devastating effects on the psychological and financial resources of the patient, family, and ...
    • Automated white matter fiber tract identification in patients with brain tumors 

      O’Donnell, Lauren J.; Suter, Yannick; Rigolo, Laura; Kahali, Pegah; Zhang, Fan; Norton, Isaiah; Albi, Angela; Olubiyi, Olutayo; Meola, Antonio; Essayed, Walid I.; Unadkat, Prashin; Ciris, Pelin Aksit; Wells, William M.; Rathi, Yogesh; Westin, Carl-Fredrik; Golby, Alexandra J. (Elsevier, 2016)
      We propose a method for the automated identification of key white matter fiber tracts for neurosurgical planning, and we apply the method in a retrospective study of 18 consecutive neurosurgical patients with brain tumors. ...
    • Biomarkers for Identifying First-Episode Schizophrenia Patients Using Diffusion Weighted Imaging 

      Rathi, Yogesh; Malcolm, James; Michailovich, Oleg; Goldstein, Jill M.; Seidman, Larry Joel; McCarley, Robert William; Westin, Carl-Fredrik; Shenton, Martha Elizabeth (Springer Science + Business Media, 2010)
      Recent advances in diffusion weighted MR imaging (dMRI) has made it a tool of choice for investigating white matter abnormalities of the brain and central nervous system. In this work, we design a system that detects ...
    • Cingulate fasciculus integrity disruption in schizophrenia: a magnetic resonance diffusion tensor imaging study 

      Kubicki, Marek R.; Westin, Carl-Fredrik; Nestor, Paul Gerard; Wible, Cynthia Gayle; Frumin, Melissa; Maier, Stephan Ernst; Kikinis, Ron; Jolesz, Ferenc A.; McCarley, Robert William; Shenton, Martha Elizabeth (Elsevier BV, 2003)
      Background: Evidence suggests that a disruption in limbic system network integrity and, in particular, the cingulate gyrus (CG), may play a role in the pathophysiology of schizophrenia; however, the cingulum bundle (CB), ...
    • Comparison of Single-Shot Echo-Planar and Line Scan Protocols for Diffusion Tensor Imaging 

      Kubicki, Marek R.; Maier, Stephan Ernst; Westin, Carl-Fredrik; Mamata, Hatsuho; Ersner-Hershfield, Hal; Estepar, Raul; Kikinis, Ron; Jolesz, Ferenc A.; McCarley, Robert William; Shenton, Martha Elizabeth (Elsevier, 2004)
      Rationale and Objectives: Both single-shot diffusion-weighted echo-planar imaging (EPI) and line scan diffusion imaging (LSDI) can be used to obtain magnetic resonance diffusion tensor data and to calculate directionally ...
    • Corpus Callosum Abnormalities and Their Association with Psychotic Symptoms in Patients with Schizophrenia 

      Whitford, Thomas; Kubicki, Marek R.; Schneiderman, Jason S.; O, Lauren J.; King, Rebecca; Alvarado, Jorge L.; Khan, Usman; Markant, Douglas; Nestor, Paul Gerard; Niznikiewicz, Margaret A.; McCarley, Robert William; Westin, Carl-Fredrik; Shenton, Martha Elizabeth (Elsevier BV, 2010)
      Background—Whilst the neuroanatomical underpinnings of the functional brain disconnectivity observed in patients with schizophrenia remain elusive, white matter fiber bundles of the brain are a likely candidate given that ...
    • Diffusion Tensor Imaging and Its Application to Neuropsychiatric Disorders 

      Kubicki, Marek R.; Westin, Carl-Fredrik; Maier, Stephan Ernst; Mamata, Hatsuho; Frumin, Melissa; Ersner-Hershfield, Hal; Kikinis, Ron; Jolesz, Ferenc A.; McCarley, Robert William; Shenton, Martha Elizabeth (Ovid Technologies (Wolters Kluwer Health), 2002)
      Magnetic resonance diffusion tensor imaging (DTI) is a new technique that can be used to visualize and measure the diffusion of water in brain tissue; it is particularly useful for evaluating white matter abnormalities. ...
    • Diffusion tractography of the fornix in schizophrenia 

      Fitzsimmons, Jennifer J; Kubicki, Marek R.; Smith, K.; Bushell, G.; Estepar, R. San Jose; Westin, Carl-Fredrik; Nestor, Paul Gerard; Niznikiewicz, Margaret A.; Kikinis, Ron; McCarley, Robert William; Shenton, Martha Elizabeth (Elsevier BV, 2009)
      Background: White matter fiber tracts, especially those interconnecting the frontal and temporal lobes, are likely implicated in pathophysiology of schizophrenia. Very few studies, however, have focused on the fornix, a ...
    • DTI and MTR abnormalities in schizophrenia: Analysis of white matter integrity 

      Kubicki, Marek R.; Park, H.; Westin, Carl-Fredrik; Nestor, Paul Gerard; Mulkern, Robert Vincent; Maier, Stephan Ernst; Niznikiewicz, Margaret A.; Connor, E.E.; Levitt, James Jonathan; Frumin, Melissa; Kikinis, Ron; Jolesz, Ferenc A.; McCarley, Robert William; Shenton, Martha Elizabeth (Elsevier BV, 2005)
      Diffusion tensor imaging (DTI) studies in schizophrenia demonstrate lower anisotropic diffusion within white matter due either to loss of coherence of white matter fiber tracts, to changes in the number and/or density of ...
    • Estimation of Bounded and Unbounded Trajectories in Diffusion MRI 

      Ning, Lipeng; Westin, Carl-Fredrik; Rathi, Yogesh (Frontiers Media S.A., 2016)
      Disentangling the tissue microstructural information from the diffusion magnetic resonance imaging (dMRI) measurements is quite important for extracting brain tissue specific measures. The autocorrelation function of ...
    • Estimation of Extracellular Volume from Regularized Multi-shell Diffusion MRI 

      Pasternak, Ofer; Shenton, Martha Elizabeth; Westin, Carl-Fredrik (Springer Science + Business Media, 2012)
      Diffusion MRI measures micron scale displacement of water molecules, providing unique insight into microstructural tissue architecture. However, current practical image resolution is in the millimeter scale, and thus ...
    • Excessive Extracellular Volume Reveals a Neurodegenerative Pattern in Schizophrenia Onset 

      Pasternak, Ofer; Westin, Carl-Fredrik; Bouix, Sylvain; Seidman, Larry Joel; Goldstein, Jill M.; Woo, Tsung-Ung Wilson; Petryshen, Tracey Lynn; Mesholam-Gately, Raquelle; McCarley, Robert William; Kikinis, Ron; Shenton, Martha Elizabeth; Kubicki, Marek R. (Society for Neuroscience, 2012)
      Diffusion MRI has been successful in identifying the existence of white matter abnormalities in schizophrenia in vivo. However, the role of these abnormalities in the etiology of schizophrenia is not well understood. ...
    • Extended Broca’s Area in the Functional Connectome of Language in Adults: Combined Cortical and Subcortical Single-Subject Analysis Using fMRI and DTI Tractography 

      Lemaire, Jean-Jacques; Golby, Alexandra Jacqueline; Wells, William Mercer; Pujol, Sonia; Tie, Yanmei; Rigolo, Laura; Yarmarkovich, Alexander; Pieper, Steve; Westin, Carl-Fredrik; Jolesz, Ferenc A.; Kikinis, Ron (Springer Nature, 2012)
      Traditional models of the human language circuitry encompass three cortical areas, Broca’s, Geschwind’s and Wernicke’s, and their connectivity through white matter fascicles. The neural connectivity deep to these cortical ...
    • Fiber Bundle Estimation and Parameterization 

      Niethammer, Marc; Bouix, Sylvain; Westin, Carl-Fredrik; Shenton, Martha Elizabeth (Springer Science + Business Media, 2006)
      Individual white matter fibers cannot be resolved by current magnetic resonance (MR) technology. Many fibers of a fiber bundle will pass through an individual volume element (voxel). Individual visualized fiber tracts are ...
    • Fiber clustering versus the parcellation-based connectome 

      O'Donnell, Lauren Jean; Golby, Alexandra Jacqueline; Westin, Carl-Fredrik (Elsevier BV, 2013)
      We compare two strategies for modeling the connections of the brain's white matter: fiber clustering and the parcellation-based connectome. Both methods analyze diffusion magnetic resonance imaging fiber tractography to ...
    • Fiber geometry in the corpus callosum in schizophrenia: Evidence for transcallosal misconnection 

      Whitford, Thomas; Savadjiev, Peter; Kubicki, Marek R.; O, Lauren J.; Terry, Douglas P.; Bouix, Sylvain; Westin, Carl-Fredrik; Schneiderman, Jason S.; Bobrow, Laurel; Rausch, Andrew C.; Niznikiewicz, Margaret A.; Nestor, Paul Gerard; Pantelis, Christos; Wood, Stephen J.; McCarley, Robert William; Shenton, Martha Elizabeth (Elsevier BV, 2011)
      Background—Structural abnormalities in the callosal fibers connecting the heteromodal association areas of the prefrontal and temporoparietal cortices bilaterally have been suggested to play a role in the etiology of ...
    • The Fiber Laterality Histogram: A New Way to Measure White Matter Asymmetry 

      O’Donnell, Lauren J.; Westin, Carl-Fredrik; Norton, Isaiah Hakim; Whalen, Stephen; Rigolo, Laura; Propper, Ruth; Golby, Alexandra Jacqueline (Springer Berlin Heidelberg, 2010)
      The quantification of brain asymmetries may provide biomarkers for presurgical localization of language function and can improve our understanding of neural structure-function relationships in health and disease. We propose ...
    • A filtered approach to neural tractography using the Watson directional function 

      Malcolm, James G.; Michailovich, Oleg; Bouix, Sylvain; Westin, Carl-Fredrik; Shenton, Martha Elizabeth; Rathi, Yogesh (Elsevier BV, 2010)
      We propose a technique to simultaneously estimate the local fiber orientations and perform multifiber tractography. Existing techniques estimate the local fiber orientation at each voxel independently so there is no running ...