Browsing by Author "Sadri-Vakili, Ghazaleh"
Now showing items 1-4 of 4
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Alterations in Brain-Derived Neurotrophic Factor in the Mouse Hippocampus Following Acute but Not Repeated Benzodiazepine Treatment
Licata, Stephanie C.; Shinday, Nina M.; Huizenga, Megan N.; Darnell, Shayna B.; Sangrey, Gavin R.; Rudolph, Uwe; Rowlett, James K.; Sadri-Vakili, Ghazaleh (Public Library of Science, 2013)Benzodiazepines (BZs) are safe drugs for treating anxiety, sleep, and seizure disorders, but their use also results in unwanted effects including memory impairment, abuse, and dependence. The present study aimed to reveal ... -
Epigenetic Inheritance of a Cocaine Resistance Phenotype
Vassoler, Fair M.; White, Samantha L.; Schmidt, Heath D.; Sadri-Vakili, Ghazaleh; Pierce, R. Christopher (2012)A heritable phenotype resulting from the self-administration of cocaine in rats was delineated. We observed delayed acquisition and reduced maintenance of cocaine self-administration in male, but not female, offspring of ... -
Huntingtin Modulates Transcription, Occupies Gene Promoters In Vivo, and Binds Directly to DNA in a Polyglutamine-Dependent Manner
Benn, C. L.; Sun, T.; Sadri-Vakili, Ghazaleh; McFarland, K. N.; DiRocco, D. P.; Yohrling, G. J.; Clark, Timothy William; Bouzou, B.; Cha, J.-H. J. (Society for Neuroscience, 2008)Transcriptional dysregulation is a central pathogenic mechanism in Huntington's disease, a fatal neurodegenerative disorder associated with polyglutamine (polyQ) expansion in the huntingtin (Htt) protein. In this study, ... -
YAP Subcellular Localization and Hippo Pathway Transcriptome Analysis in Pediatric Hepatocellular Carcinoma
LaQuaglia, Michael J.; Grijalva, James L.; Mueller, Kaly A.; Perez-Atayde, Antonio R.; Kim, Heung Bae; Sadri-Vakili, Ghazaleh; Vakili, Khashayar (Nature Publishing Group, 2016)Pediatric hepatocellular carcinoma (HCC) is a rare tumor which is associated with an extremely high mortality rate due to lack of effective chemotherapy. Recently, the Hippo pathway and its transcriptional co-activator ...