Browsing by Author "Cortes, Mauricio"

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    • Accumulation of the Vitamin D Precursor Cholecalciferol Antagonizes Hedgehog Signaling to Impair Hemogenic Endothelium Formation 

      Cortes, Mauricio; Liu, Sarah Y.; Kwan, Wanda; Alexa, Kristen; Goessling, Wolfram; North, Trista E. (Elsevier, 2015)
      Summary Hematopoietic stem and progenitor cells (HSPCs) are born from hemogenic endothelium in the dorsal aorta. Specification of this hematopoietic niche is regulated by a signaling axis using Hedgehog (Hh) and Notch, ...

    • Single-cell transcriptional analysis of normal, aberrant, and malignant hematopoiesis in zebrafish 

      Moore, Finola E.; Garcia, Elaine G.; Lobbardi, Riadh; Jain, Esha; Tang, Qin; Moore, John C.; Cortes, Mauricio; Molodtsov, Aleksey; Kasheta, Melissa; Luo, Christina C.; Garcia, Amaris J.; Mylvaganam, Ravi; Yoder, Jeffrey A.; Blackburn, Jessica S.; Sadreyev, Ruslan I.; Ceol, Craig J.; North, Trista E.; Langenau, David M. (The Rockefeller University Press, 2016)
      Hematopoiesis culminates in the production of functionally heterogeneous blood cell types. In zebrafish, the lack of cell surface antibodies has compelled researchers to use fluorescent transgenic reporter lines to label ...