Now showing items 1-7 of 7

    • Alu and LINE-1 methylation and lung function in the normative ageing study 

      Lange, Nancy E; Sordillo, Joanne; Tarantini, Letizia; Bollati, Valentina; Sparrow, David; Vokonas, Pantel; Zanobetti, Antonella; Schwartz, Joel David; Baccarelli, Andrea; Litonjua, Augusto Ampil; Demeo, Dawn Lisa (BMJ Publishing Group, 2012)
      Objectives: To investigate the association between methylation of transposable elements Alu and long-interspersed nuclear elements (LINE-1) and lung function. Design: Cohort study. Setting: Outpatient Veterans Administration ...
    • Diagnostic accuracy of the bronchodilator response in children 

      Tse, Szewah; Gold, Diane R.; Sordillo, Joanne; Hoffman, Elaine; Gillman, Matthew William; Rifas-Shiman, Sheryl Lynn; Fuhlbrigge, Anne Louise; Tantisira, Kelan; Weiss, Scott Tillman; Litonjua, Augusto Ampil (Elsevier BV, 2013)
      Background: The bronchodilator response (BDR) reflects the reversibility of airflow obstruction and is recommended as an adjunctive test to diagnose asthma. The validity of the commonly used definition of BDR, a 12% or ...
    • Effects of Endotoxin Exposure on Childhood Asthma Risk are Modified by a Genetic Polymorphism in ACAA1 

      Sordillo, Joanne; Sharma, Sunita; Poon, Audrey; Su, Jessica Ann Lasky; Belanger, Kathleen; Milton, Donald Kirby; Bracken, Michael B; Triche, Elizabeth W; Leaderer, Brian P; Gold, Diane R.; Litonjua, Augusto Ampil (BioMed Central, 2011)
      Background: Polymorphisms in the endotoxin-mediated TLR4 pathway genes have been associated with asthma and atopy. We aimed to examine how genetic polymorphisms in innate immunity pathways interact with endotoxin to influence ...
    • Genome-wide expression profiles identify potential targets for gene-environment interactions in asthma severity 

      Sordillo, Joanne; Kelly, Roxanne; Bunyavanich, Supinda; McGeachie, Michael John; Qiu, Weiliang; Croteau-Chonka, Damien C; Soto-Quiros, Manuel; Avila, Lydiana; Celedón, Juan C.; Brehm, John M.; Weiss, Scott Tillman; Gold, Diane R.; Litonjua, Augusto Ampil (Elsevier BV, 2015)
      Background: Gene by environment interaction (G × E) studies utilizing GWAS data are often underpowered after adjustment for multiple comparisons. Differential gene expression, in response to the exposure of interest, may ...
    • Longitudinal Prediction of the Infant Gut Microbiome with Dynamic Bayesian Networks 

      McGeachie, Michael John; Sordillo, Joanne; Gibson, Travis Eli; Weinstock, George M.; Liu, Yang-Yu; Gold, Diane R.; Weiss, Scott Tillman; Litonjua, Augusto (Nature Publishing Group, 2016)
      Sequencing of the 16S rRNA gene allows comprehensive assessment of bacterial community composition from human body sites. Previously published and publicly accessible data on 58 preterm infants in the Neonatal Intensive ...
    • The metabolomics of asthma control: a promising link between genetics and disease 

      McGeachie, Michael J; Dahlin, Amber; Qiu, Weiliang; Croteau-Chonka, Damien C; Savage, Jessica; Wu, Ann Chen; Wan, Emily S; Sordillo, Joanne E; Al-Garawi, Amal; Martinez, Fernando D; Strunk, Robert C; Lemanske, Robert F; Liu, Andrew H; Raby, Benjamin A; Weiss, Scott; Clish, Clary B; Lasky-Su, Jessica A (John Wiley & Sons, Ltd, 2015)
      Short-acting β agonists (e.g., albuterol) are the most commonly used medications for asthma, a disease that affects over 300 million people in the world. Metabolomic profiling of asthmatics taking β agonists presents a new ...
    • Whole genome prediction and heritability of childhood asthma phenotypes 

      McGeachie, Michael J.; Clemmer, George L.; Croteau‐Chonka, Damien C.; Castaldi, Peter J.; Cho, Michael H.; Sordillo, Joanne E.; Lasky‐Su, Jessica A.; Raby, Benjamin A.; Tantisira, Kelan G.; Weiss, Scott T. (John Wiley and Sons Inc., 2016)
      Abstract Introduction: While whole genome prediction (WGP) methods have recently demonstrated successes in the prediction of complex genetic diseases, they have not yet been applied to asthma and related phenotypes. ...