Now showing items 1-13 of 13

    • Body Mass Index Genetic Risk Score and Endometrial Cancer Risk 

      Prescott, Jennifer; Setiawan, Veronica W.; Wentzensen, Nicolas; Schumacher, Fredrick; Yu, Herbert; Delahanty, Ryan; Bernstein, Leslie; Chanock, Stephen J.; Chen, Chu; Cook, Linda S.; Friedenreich, Christine; Garcia-Closas, Monserrat; Haiman, Christopher A.; Le Marchand, Loic; Liang, Xiaolin; Lissowska, Jolanta; Lu, Lingeng; Magliocco, Anthony M.; Olson, Sara H.; Risch, Harvey A.; Shu, Xiao-Ou; Ursin, Giske; Yang, Hannah P.; Kraft, Peter; De Vivo, Immaculata (Public Library of Science, 2015)
      Genome-wide association studies (GWAS) have identified common variants that predispose individuals to a higher body mass index (BMI), an independent risk factor for endometrial cancer. Composite genotype risk scores (GRS) ...
    • Childhood Physical and Sexual Abuse History and Leukocyte Telomere Length among Women in Middle Adulthood 

      Mason, Susan M.; Prescott, Jennifer; Tworoger, Shelley S.; DeVivo, Immaculata; Rich-Edwards, Janet W. (Public Library of Science, 2015)
      Objective: Abuse victimization in childhood is associated with a variety of age-related cardiometabolic diseases, but the mechanisms remain unknown. Telomeres, which form the protective caps at the ends of chromosomes, ...
    • Evidence of Differential Effects of Vitamin D Receptor Variants on Epithelial Ovarian Cancer Risk by Predicted Vitamin D Status 

      Prescott, Jennifer; Bertrand, Kimberly A.; Reid, Brett M.; Permuth-Wey, Jennifer; De Vivo, Immaculata; Cramer, Daniel W.; Terry, Kathryn L.; Tworoger, Shelley S. (Frontiers Media S.A., 2014)
      Introduction: Experimental studies suggest vitamin D inhibits ovarian carcinogenesis. Yet, epidemiologic studies of ovarian cancer risk and lifestyle correlates of vitamin D status, plasma 25-hydroxyvitamin D [25(OH)D], ...
    • Exome-Wide Association Study of Endometrial Cancer in a Multiethnic Population 

      Chen, Maxine M.; Crous-Bou, Marta; Setiawan, Veronica W.; Prescott, Jennifer; Olson, Sara H.; Wentzensen, Nicolas; Black, Amanda; Brinton, Louise; Chen, Chu; Chen, Constance; Cook, Linda S.; Doherty, Jennifer; Friedenreich, Christine M.; Hankinson, Susan E.; Hartge, Patricia; Henderson, Brian E.; Hunter, David J.; Le Marchand, Loic; Liang, Xiaolin; Lissowska, Jolanta; Lu, Lingeng; Orlow, Irene; Petruzella, Stacey; Polidoro, Silvia; Pooler, Loreall; Rebbeck, Timothy R.; Risch, Harvey; Sacerdote, Carlotta; Schumacher, Frederick; Sheng, Xin; Shu, Xiao-ou; Weiss, Noel S.; Xia, Lucy; Van Den Berg, David; Yang, Hannah P.; Yu, Herbert; Chanock, Stephen; Haiman, Christopher; Kraft, Peter; De Vivo, Immaculata (Public Library of Science, 2014)
      Endometrial cancer (EC) contributes substantially to total burden of cancer morbidity and mortality in the United States. Family history is a known risk factor for EC, thus genetic factors may play a role in EC pathogenesis. ...
    • Genetic Predisposition to Higher Body Mass Index or Type 2 Diabetes and Leukocyte Telomere Length in the Nurses' Health Study 

      Du, Mengmeng; Prescott, Jennifer; Cornelis, Marilyn; Hankinson, Susan Elizabeth; Giovannucci, Edward L.; Kraft, Phillip L.; De Vivo, Immaculata (Public Library of Science, 2013)
      Background: Although cross-sectional studies have linked higher body mass index (BMI) and type 2 diabetes (T2D) to shortened telomeres, whether these metabolic conditions play a causal role in telomere biology is unknown. ...
    • A Genome-Wide Association Meta-Analysis of Circulating Sex Hormone–Binding Globulin Reveals Multiple Loci Implicated in Sex Steroid Hormone Regulation 

      Coviello, Andrea D.; Haring, Robin; Wellons, Melissa; Vaidya, Dhananjay; Lehtimäki, Terho; Keildson, Sarah; Lunetta, Kathryn L.; He, Chunyan; Fornage, Myriam; Lagou, Vasiliki; Mangino, Massimo; Onland-Moret, N. Charlotte; Eriksson, Joel; Garcia, Melissa; Liu, Yong Mei; Koster, Annemarie; Lohman, Kurt; Lyytikäinen, Leo-Pekka; Petersen, Ann-Kristin; Stolk, Lisette; Vandenput, Liesbeth; Wood, Andrew R.; Zhuang, Wei Vivian; Ruokonen, Aimo; Hartikainen, Anna-Liisa; Pouta, Anneli; Bandinelli, Stefania; Biffar, Reiner; Brabant, Georg; Chen, Yuhui; Cummings, Steven; Ferrucci, Luigi; Gunter, Marc J.; Martikainen, Hannu; Homuth, Georg; Illig, Thomas; Jansson, John-Olov; Karlsson, Magnus; Kettunen, Johannes; Liu, Jingmin; Ljunggren, Östen; Lorentzon, Mattias; Maggio, Marcello; Markus, Marcello R. P.; Mellström, Dan; Miljkovic, Iva; Mirel, Daniel; Morin Papunen, Laure; Peeters, Petra H. M.; Prokopenko, Inga; Raffel, Leslie; Reincke, Martin; Reiner, Alex P.; Rivadeneira, Fernando; Schwartz, Stephen M.; Siscovick, David; Soranzo, Nicole; Stöckl, Doris; Uitterlinden, André G.; van Gils, Carla H.; Vasan, Ramachandran S.; Wichmann, H.-Erich; Zhai, Guangju; Bhasin, Shalender; Bidlingmaier, Martin; Chanock, Stephen J.; Harris, Tamara B.; Kähönen, Mika; Liu, Simin; Ouyang, Pamela; Spector, Tim D.; van der Schouw, Yvonne T.; Viikari, Jorma; Wallaschofski, Henri; McCarthy, Mark I.; Frayling, Timothy M.; Murray, Anna; Franks, Steve; Järvelin, Marjo-Riitta; de Jong, Frank H.; Raitakari, Olli; Teumer, Alexander; Ohlsson, Claes; Murabito, Joanne M.; Perry, John R. B.; Chen, Brian; Prescott, Jennifer; Cox, David G.; Hankinson, Susan Elizabeth; Hofman, Albert; Johnson, Andrew D.; Karasik, David; Kiel, Douglas P.; Nelson, Sarah; Rexrode, Kathryn Marian; Tworoger, Shelley Slate; De Vivo, Immaculata; Hunter, David J.; Kraft, Peter (Public Library of Science, 2012)
      Sex hormone-binding globulin (SHBG) is a glycoprotein responsible for the transport and biologic availability of sex steroid hormones, primarily testosterone and estradiol. SHBG has been associated with chronic diseases ...
    • Genome-Wide Association Study of Circulating Estradiol, Testosterone, and Sex Hormone-Binding Globulin in Postmenopausal Women 

      Prescott, Jennifer; Thompson, Deborah J.; Kraft, Peter; Chanock, Stephen J.; Audley, Tina; Brown, Judith; Leyland, Jean; Folkerd, Elizabeth; Doody, Deborah; Hankinson, Susan Elizabeth; Hunter, David J.; Jacobs, Kevin B.; Dowsett, Mitch; Cox, David G.; Easton, Douglas F.; De Vivo, Immaculata (Public Library of Science, 2012)
      Genome-wide association studies (GWAS) have successfully identified common genetic variants that contribute to breast cancer risk. Discovering additional variants has become difficult, as power to detect variants of weaker ...
    • Genome-wide association study of endometrial cancer in E2C2 

      De Vivo, Immaculata; Prescott, Jennifer; Setiawan, Veronica Wendy; Olson, Sara H.; Wentzensen, Nicolas; Attia, John; Black, Amanda; Brinton, Louise; Chen, Chu; Chen, Constance; Cook, Linda S.; Crous-Bou, Marta; Doherty, Jennifer; Dunning, Alison M.; Easton, Douglas F.; Friedenreich, Christine M.; Garcia-Closas, Montserrat; Gaudet, Mia M.; Haiman, Christopher; Hankinson, Susan E.; Hartge, Patricia; Henderson, Brian E.; Holliday, Elizabeth; Horn-Ross, Pamela L.; Hunter, David J.; Le Marchand, Loic; Liang, Xiaolin; Lissowska, Jolanta; Long, Jirong; Lu, Lingeng; Magliocco, Anthony M.; McEvoy, Mark; O’Mara, Tracy A.; Orlow, Irene; Painter, Jodie N.; Pooler, Loreall; Rastogi, Radhai; Rebbeck, Timothy R.; Risch, Harvey; Sacerdote, Carlotta; Schumacher, Fredrick; Scott, Rodney J.; Sheng, Xin; Shu, Xiao-ou; Spurdle, Amanda B.; Thompson, Deborah; VanDen Berg, David; Weiss, Noel S.; Xia, Lucy; Xiang, Yong-Bing; Yang, Hannah P.; Yu, Herbert; Zheng, Wei; Chanock, Stephen; Kraft, Peter (Springer Berlin Heidelberg, 2013)
      Endometrial cancer (EC), a neoplasm of the uterine epithelial lining, is the most common gynecological malignancy in developed countries and the fourth most common cancer among US women. Women with a family history of EC ...
    • Healthy Lifestyle and Leukocyte Telomere Length in U.S. Women 

      Sun, Qi; Shi, Ling; Prescott, Jennifer; Chiuve, Stephanie Elizabeth; Hu, Frank B.; De Vivo, Immaculata; Stampfer, Meir; Franks, Paul W.; Manson, JoAnn Elisabeth; Rexrode, Kathryn Marian (Public Library of Science, 2012)
      Context: Whether a healthy lifestyle may be associated with longer telomere length is largely unknown. Objectives: To examine healthy lifestyle practices, which are primary prevention measures against major age-related ...
    • High Phobic Anxiety Is Related to Lower Leukocyte Telomere Length in Women 

      Okereke, Olivia Ifeoma; Prescott, Jennifer; Wong, Jason Yat Yang; Han, Jiali; Rexrode, Kathryn Marian; De Vivo, Immaculata (Public Library of Science, 2012)
      Background: Chronic psychological distress has been linked to shorter telomeres, an indication of accelerated aging. Yet, little is known about relations of anxiety to telomeres. We examined whether a typically chronic ...
    • Mediterranean diet and telomere length in Nurses’ Health Study: population based cohort study 

      Crous-Bou, Marta; Fung, Teresa T; Prescott, Jennifer; Julin, Bettina; Du, Mengmeng; Sun, Qi; Rexrode, Kathryn M; Hu, Frank B; De Vivo, Immaculata (BMJ Publishing Group Ltd., 2014)
      Objective: To examine whether adherence to the Mediterranean diet was associated with longer telomere length, a biomarker of aging. Design: Population based cohort study. Setting: Nurses’ Health Study, an ongoing prospective ...
    • Surrogates of Long-Term Vitamin D Exposure and Ovarian Cancer Risk in Two Prospective Cohort Studies 

      Prescott, Jennifer; Bertrand, Kimberly A.; Poole, Elizabeth M.; Rosner, Bernard A.; Tworoger, Shelley S. (MDPI, 2013)
      Experimental evidence and ecologic studies suggest a protective role of vitamin D in ovarian carcinogenesis. However, epidemiologic studies using individual level data have been inconsistent. We evaluated ultraviolet (UV)-B ...
    • Telomere Length and the Risk of Cutaneous Malignant Melanoma in Melanoma-Prone Families with and without CDKN2A Mutations 

      Burke, Laura S.; Hyland, Paula L.; Pfeiffer, Ruth M.; Prescott, Jennifer; Wheeler, William; Mirabello, Lisa; Savage, Sharon A.; Burdette, Laurie; Yeager, Meredith; Chanock, Stephen; De Vivo, Immaculata; Tucker, Margaret A.; Goldstein, Alisa M.; Yang, Xiaohong R. (Public Library of Science, 2013)
      Introduction: Recent evidence suggests a link between constitutional telomere length (TL) and cancer risk. Previous studies have suggested that longer telomeres were associated with an increased risk of melanoma and larger ...