Now showing items 1-3 of 3

    • Independent Large Scale Duplications in Multiple M. tuberculosis Lineages Overlapping the Same Genomic Region 

      Weiner, Brian; Victor, Thomas C.; Warren, Robert M.; Plikaytis, Bonnie B.; Posey, James E.; van Helden, Paul D.; Gey van Pittius, Nicolass C.; Koehrsen, Michael; Sisk, Peter; Stolte, Christian; White, Jared; Gagneux, Sebastien; Birren, Bruce; Gomez, James E.; Sloutsky, Alexander; Hung, Deborah Tan; Murray, Megan Blanche; Galagan, James E (Public Library of Science, 2012)
      Mycobacterium tuberculosis, the causative agent of most human tuberculosis, infects one third of the world's population and kills an estimated 1.7 million people a year. With the world-wide emergence of drug resistance, ...
    • Large-Scale Chemical–genetics Yields New M. Tuberculosis Inhibitor Classes 

      LaVerriere, Emily; Meyer, Elisabeth; Kawate, Tomohiko; Gomez, James; Gardner, Michelle; Cigarroa Kennedy, Sofia; Wakabayashi, Shoko; Watson, Christopher; Fitzgerald, Michael; Johnson, Eachan; Office, Emma; Stanley, Mary; Audette, Rebecca; Bandyopadhyay, Nirmalya; Betancourt, Natalia; Delano, Kayla; Da Silva, Israel; Davis, Joshua; Gallo, Christina; Golas, Aaron; Guinn, Kristine; Korn, Rebecca; McConnell, Jennifer; Moss, Caitlin; Murphy, Kenan; Nietupski, Raymond; Papavinasasundaram, Kadamba; Pinkham, Jessica; Pino, Paula; Proulx, Megan; Ruecker, Nadine; Song, Naomi; Thompson, Matthew; Trujillo, Carolina; Metcalf-Wallach, Joshua; Ioerger, Thomas; Lander, Eric; Hubbard, Brian; Serrano-Wu, Michael; Ehrt, Sabine; Rubin, Eric; Sassetti, Christopher; Schnappinger, Dirk; Hung, Deborah (Springer Science and Business Media LLC, 2019-06-19)
      New antibiotics are needed to combat rising resistance, with new Mycobacterium tuberculosis (Mtb) drugs of highest priority. Conventional whole-cell and biochemical antibiotic screens have failed. We developed a novel ...
    • Sensitive, Specific Polymorphism Discovery in Bacteria Using Massively Parallel Sequencing 

      Nusbaum, Chad; Ohsumi, Toshiro K.; Gomez, James; Aquadro, John; Victor, Thomas C.; Warren, Robert M.; Hung, Deborah; Birren, Bruce W.; Lander, Eric; Jaffe, David B. (Nature Publishing Group, 2008)
      Our variant ascertainment algorithm, VAAL, uses massively parallel DNA sequence data to identify differences between bacterial genomes with high sensitivity and specificity. VAAL detected B98% of differences (including ...