Browsing by Author "Choi, Colin K."

Now showing items 1-2 of 2

    • A DNA-based molecular probe for optically reporting cellular traction forces 

      Blakely, Brandon L.; Dumelin, Christoph E.; Trappmann, Britta; McGregor, Lynn M.; Choi, Colin K.; Anthony, Peter C.; Duesterberg, Van K.; Baker, Brendon M.; Block, Steven M.; Liu, David R.; Chen, Christopher S. (2014)
      We developed molecular tension probes (TPs) that report traction forces of adherent cells with high spatial resolution, can be linked to virtually any surface, and obviate monitoring deformations of elastic substrates. TPs ...

    • A proteomic approach reveals integrin activation state-dependent control of microtubule cortical targeting 

      Byron, Adam; Askari, Janet A.; Humphries, Jonathan D.; Jacquemet, Guillaume; Koper, Ewa J.; Warwood, Stacey; Choi, Colin K.; Stroud, Matthew J.; Chen, Christopher S.; Knight, David; Humphries, Martin J. (Nature Pub. Group, 2015)
      Integrin activation, which is regulated by allosteric changes in receptor conformation, enables cellular responses to the chemical, mechanical and topological features of the extracellular microenvironment. A global view ...