Now showing items 1-3 of 3

    • Clinical Profiling of BCL-2 Family Members in the Setting of BRAF Inhibition Offers a Rationale for Targeting De Novo Resistance Using BH3 Mimetics 

      Frederick, Dennie T.; Salas Fragomeni, Roberto A.; Schalck, Aislyn; Ferreiro-Neira, Isabel; Hoff, Taylor; Cooper, Zachary A.; Haq, Rizwan; Panka, David J.; Kwong, Lawrence N.; Davies, Michael A.; Cusack, James C.; Flaherty, Keith T.; Fisher, David E.; Mier, James W.; Wargo, Jennifer A.; Sullivan, Ryan J. (Public Library of Science, 2014)
      While response rates to BRAF inhibitiors (BRAFi) are high, disease progression emerges quickly. One strategy to delay the onset of resistance is to target anti-apoptotic proteins such as BCL-2, known to be associated with ...
    • The effect of neoadjuvant chemoradiation therapy on the prognostic value of lymph nodes after rectal cancer surgery 

      Klos, Coen L.; Shellito, Paul Clarke; Rattner, David William; Hodin, Richard; Cusack, James C.; Bordeianou, Liliana Grigorievna; Sylla, Patricia; Hong, Theodore Sunki; Blaszkowsky, Lawrence Scott; Ryan, Davis P.; Lauwers, Gregory Y.; Chang, Yu Chiao; Berger, David Lawrence (Elsevier BV, 2010)
      Background: Neoadjuvant therapy may affect the prognostic impact of total lymph node harvests and lymph node positivity after surgery for rectal cancer. Methods: We performed a retrospective review of 390 consecutive ...
    • Mutational Analysis of Merkel Cell Carcinoma 

      Erstad, Derek J.; Cusack, James C. (MDPI, 2014)
      Merkel cell carcinoma (MCC) is an aggressive cutaneous neuroendocrine malignancy that is associated with a poor prognosis. The pathogenesis of MCC is not well understood, and despite a recent plethora of mutational analyses, ...