Browsing by Author "Kleiner, Ralph"
Now showing items 1-3 of 3
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Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones
Maianti, Juan Pablo; McFedries, Amanda; Foda, Zachariah H.; Kleiner, Ralph; Du, Xiu Quan; Leissring, Malcolm A.; Tang, Wei-Jen; Charron, Maureen J.; Seeliger, Markus A.; Saghatelian, Alan; Liu, David Ruchien (Nature Publishing Group, 2014)Despite decades of speculation that inhibiting endogenous insulin degradation might treat type-2 diabetes, and the identification of IDE (insulin-degrading enzyme) as a diabetes susceptibility gene, the relationship between ... -
DNA-templated polymerization of side-chain-functionalized peptide nucleic acid aldehydes
Kleiner, Ralph; Brudno, Yevgeny; Birnbaum, Michael E.; Liu, David Ruchien (American Chemical Society (ACS), 2008)The DNA-templated polymerization of synthetic building blocks provides a potential route to the laboratory evolution of sequence-defined polymers with structures and properties not necessarily limited to those of natural ... -
In Vitro Selection of a DNA-Templated Small-Molecule Library Reveals a Class of Macrocyclic Kinase Inhibitors
Kleiner, Ralph Elliot; Dumelin, Christoph; Tiu, Gerald C.; Sakurai, Kaori; Liu, David Ruchien (American Chemical Society, 2010)DNA-templated organic synthesis enables the translation of DNA sequences into synthetic small-molecule libraries suitable for in vitro selection. Previously, we described the DNA-templated multistep synthesis of a ...