Browsing by Author "Kuo, Chueh-Ling"

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    • Thiostrepton interacts covalently with Rpt subunits of the 19S proteasome and proteasome substrates 

      Sandu, Cristinel; Chandramouli, Nagaranjan; Glickman, Joseph Fraser; Molina, Henrik; Kuo, Chueh-Ling; Kukushkin, Nikolay; Goldberg, Alfred L; Steller, Hermann (John Wiley & Sons, Ltd, 2015)
      Here, we report a novel mechanism of proteasome inhibition mediated by Thiostrepton (Thsp), which interacts covalently with Rpt subunits of the 19S proteasome and proteasome substrates. We identified Thsp in a cell-based ...