Now showing items 1-11 of 11

    • Bee venom processes human skin lipids for presentation by CD1a 

      Bourgeois, Elvire A.; Subramaniam, Sumithra; Cheng, Tan-Yun; De Jong, Annemieke; Layre, Emilie; Ly, Dalam; Salimi, Maryam; Legaspi, Annaliza; Modlin, Robert L.; Salio, Mariolina; Cerundolo, Vincenzo; Moody, D. Branch; Ogg, Graham (The Rockefeller University Press, 2015)
      Venoms frequently co-opt host immune responses, so study of their mode of action can provide insight into novel inflammatory pathways. Using bee and wasp venom responses as a model system, we investigated whether venoms ...
    • CD1-restricted adaptive immune responses to Mycobacteria in human group 1 CD1 transgenic mice 

      Felio, Kyrie; Nguyen, Hanh; Dascher, Christopher C.; Choi, Hak-Jong; Li, Sha; Zimmer, Michael I.; Colmone, Angela; Moody, D Branch; Brenner, Michael Barry; Wang, Chyung-Ru (Rockefeller University Press, 2009)
      Group 1 CD1 (CD1a, CD1b, and CD1c)–restricted T cells recognize mycobacterial lipid antigens and are found at higher frequencies in Mycobacterium tuberculosis (Mtb)–infected individuals. However, their role and dynamics ...
    • CD1b Tetramers Bind \(\alpha \beta\) T Cell Receptors to Identify a Mycobacterial Glycolipid-Reactive T Cell Repertoire in Humans 

      Cheng, Tan-Yun; Turner, Marie; Seshadri, Chetan; Schiefner, Andre; Kalathur, Ravi C.; Annand, John W.; de Jong, Annemieke; Shires, John; Wilson, Ian A.; Altman, John D.; Kasmar, Anne G.; Van Rhijn, Ildiko; Leon, Luis; Brenner, Michael Barry; Moody, D Branch (The Rockefeller University Press, 2011)
      Microbial lipids activate T cells by binding directly to CD1 and T cell receptors (TCRs) or by indirect effects on antigen-presenting cells involving induction of lipid autoantigens, CD1 transcription, or cytokine release. ...
    • CD1c bypasses lysosomes to present a lipopeptide antigen with 12 amino acids 

      Van Rhijn, Ildiko; De Jong, Annemieke; Vazquez, Jenny; Cheng, Tan-Yun; Barral, Duarte C.; León, Luis; Riese, Richard; Costello, Catherine E.; Porcelli, Steven A.; Briken, Volker; Young, David Stephenson; Young, David C.; Talekar, Rahul Subhash; Brenner, Michael Barry; Katz, Joel Thorp; Ruprecht, Ruth Margrit; O'Connor, Peter B.; Moody, D Branch (The Rockefeller University Press, 2009)
      The recent discovery of dideoxymycobactin (DDM) as a ligand for CD1a demonstrates how a nonribosomal lipopeptide antigen is presented to T cells. DDM contains an unusual acylation motif and a peptide sequence present only ...
    • CD1c Bypasses Lysosomes to Present a Lipopeptide Antigen with 12 Amino Acids 

      De Jong, Annemieke; Vazquez, Jenny; Cheng, Tan-Yun; Barral, Duarte C.; León, Luis; Riese, Richard; Costello, Catherine E.; Porcelli, Steven A.; Briken, Volker; Van Rhijn, Ildiko; Young, David C.; Talekar, Rahul Subhash; Brenner, Michael Barry; Katz, Joel Thorp; Ruprecht, Ruth Margrit; O'Connor, Peter B.; Moody, D Branch (The Rockefeller University Press, 2009)
      The recent discovery of dideoxymycobactin (DDM) as a ligand for CD1a demonstrates how a nonribosomal lipopeptide antigen is presented to T cells. DDM contains an unusual acylation motif and a peptide sequence present only ...
    • Cell-Envelope Remodeling as a Determinant of Phenotypic Antibacterial Tolerance in Mycobacterium tuberculosis 

      Larrouy-Maumus, Gérald; Marino, Leonardo B.; Madduri, Ashoka V. R.; Ragan, T. J.; Hunt, Debbie M.; Bassano, Lucrezia; Gutierrez, Maximiliano G.; Moody, D. Branch; Pavan, Fernando R.; de Carvalho, Luiz Pedro S. (American Chemical Society, 2016)
      The mechanisms that lead to phenotypic antibacterial tolerance in bacteria remain poorly understood. We investigate whether changes in NaCl concentration toward physiologically higher values affect antibacterial efficacy ...
    • Interpreting Expression Data with Metabolic Flux Models: Predicting Mycobacterium tuberculosis Mycolic Acid Production 

      Colijn, Caroline; Brandes, Aaron; Zucker, Jeremy Daniel Hofeld; Lun, Desmond S.; Weiner, Brian; Farhat, Maha Reda; Cheng, Tan-Yun; Moody, D Branch; Murray, Megan Blanche; Galagan, James E (Public Library of Science, 2009)
      Metabolism is central to cell physiology, and metabolic disturbances play a role in numerous disease states. Despite its importance, the ability to study metabolism at a global scale using genomic technologies is limited. ...
    • Lipidomic Analysis Links Mycobactin Synthase K to Iron Uptake and Virulence in M. tuberculosis 

      Madigan, Cressida A.; Martinot, Amanda Jezek; Wei, Jun-Rong; Madduri, Ashoka; Cheng, Tan-Yun; Young, David C.; Layre, Emilie; Murry, Jeffrey P.; Rubin, Eric J.; Moody, D. Branch (Public Library of Science, 2015)
      The prolonged survival of Mycobacterium tuberculosis (M. tb) in the host fundamentally depends on scavenging essential nutrients from host sources. M. tb scavenges non-heme iron using mycobactin and carboxymycobactin ...
    • Mycobacterial Metabolic Syndrome: LprG and Rv1410 Regulate Triacylglyceride Levels, Growth Rate and Virulence in Mycobacterium tuberculosis 

      Martinot, Amanda J.; Farrow, Mary; Bai, Lu; Layre, Emilie; Cheng, Tan-Yun; Tsai, Jennifer H.; Iqbal, Jahangir; Annand, John W.; Sullivan, Zuri A.; Hussain, M. Mahmood; Sacchettini, James; Moody, D. Branch; Seeliger, Jessica C.; Rubin, Eric J. (Public Library of Science, 2016)
      Mycobacterium tuberculosis (Mtb) mutants lacking rv1411c, which encodes the lipoprotein LprG, and rv1410c, which encodes a putative efflux pump, are dramatically attenuated for growth in mice. Here we show that loss of ...
    • T cell receptor recognition of CD1b presenting a mycobacterial glycolipid 

      Gras, Stephanie; Van Rhijn, Ildiko; Shahine, Adam; Cheng, Tan-Yun; Bhati, Mugdha; Tan, Li Lynn; Halim, Hanim; Tuttle, Kathryn D.; Gapin, Laurent; Le Nours, Jérôme; Moody, D. Branch; Rossjohn, Jamie (Nature Publishing Group, 2016)
      CD1 proteins present microbial lipids to T cells. Germline-encoded mycolyl lipid-reactive (GEM) T cells with conserved αβ T cell receptors (TCRs) recognize CD1b presenting mycobacterial mycolates. As the molecular basis ...
    • Ultralong C100 Mycolic Acids Support the Assignment of Segniliparus as a New Bacterial Genus 

      Hong, Sunhee; Cheng, Tan-Yun; Layre, Emilie; Sweet, Lindsay; Young, David C.; Posey, James E.; Butler, W. Ray; Moody, D Branch (Public Library of Science, 2012)
      Mycolic acid-producing bacteria isolated from the respiratory tract of human and non-human mammals were recently assigned as a distinct genus, Segniliparus, because they diverge from rhodococci and mycobacteria in genetic ...