Now showing items 1-5 of 5

    • Antibody-Independent, Interleukin-17A-Mediated, Cross-Serotype Immunity to Pneumococci in Mice Immunized Intranasally with the Cell Wall Polysaccharide 

      Malley, Richard; Srivastava, Amit; Lipsitch, Marc; Thompson, Claudette M.; Watkins, C.; Tzianabos, A.; Anderson, Porter (American Society for Microbiology, 2006)
      Serotype-specific immunity to Streptococcus pneumoniae is conferred by antibodies to the capsular polysaccharides, which define the 90 known serotypes. Whether antibody to the species-common cell wall polysaccharide (C-Ps) ...
    • CD4+ T cells mediate antibody-independent acquired immunity to pneumococcal colonization 

      Malley, Richard; Trzcinski, K.; Srivastava, Amit; Thompson, Claudette M.; Anderson, Porter; Lipsitch, Marc (Proceedings of the National Academy of Sciences, 2005)
      Acquired immunity to Streptococcus pneumoniae (pneumococcus) has long been assumed to depend on the presence of anticapsular antibodies. We found, however, that colonization with live pneumococci of serotypes 6B, 7F, or ...
    • Interleukin-17A Mediates Acquired Immunity to Pneumococcal Colonization 

      Gross, Jane; Bogaert, Debby; Finn, Adam; Bagrade, Linda; Zhang, Qibo; Kolls, Jay K.; Lundgren, Anna; Forte, Sophie; Lu, Ying-Jie; Srivastava, Amit Kumar; Thompson, Claudette M.; Harney, Kathleen; Anderson, Porter; Lipsitch, Marc; Malley, Richard (Public Library of Science, 2008)
      Although anticapsular antibodies confer serotype-specific immunity to pneumococci, children increase their ability to clear colonization before these antibodies appear, suggesting involvement of other mechanisms. We ...
    • Intranasal Immunization with Killed Unencapsulated Whole Cells Prevents Colonization and Invasive Disease by Capsulated Pneumococci 

      Malley, Richard; Lipsitch, Marc; Stack, Anne Marie; Saladino, R.; Fleisher, Gary Robert; Pelton, S.; Thompson, Claudette M.; Briles, D.; Anderson, Porter (American Society for Microbiology, 2001)
      A whole-cell killed unencapsulated pneumococcal vaccine given by the intranasal route with cholera toxin as an adjuvant was tested in two animal models. This vaccination was highly effective in preventing nasopharyngeal ...
    • Pneumococcal Capsular Polysaccharide Structure Predicts Serotype Prevalence 

      Weinberger, Daniel M.; Trzciński, Krzysztof; Lu, Ying-Jie; Bogaert, Debby; Brandes, Aaron; Galagan, James E; Anderson, Porter; Malley, Richard; Lipsitch, Marc (Public Library of Science, 2009)
      There are 91 known capsular serotypes of Streptococcus pneumoniae. The nasopharyngeal carriage prevalence of particular serotypes is relatively stable worldwide, but the host and bacterial factors that maintain these ...