Browsing by Author "Briscoe, David"

Now showing items 1-4 of 4

    • Key Features of the Intragraft Microenvironment that Determine Long-Term Survival Following Transplantation 

      Bruneau, Sarah; Woda, Craig B.; Daly, Kevin Patrick; Boneschansker, Leonard; Jain, Namrata G.; Kochupurakkal, Nora; Contreras, Alan Gabriel; Seto, Tatsuichiro; Briscoe, David Michael (Frontiers Research Foundation, 2012)
      In this review, we discuss how changes in the intragraft microenvironment serve to promote or sustain the development of chronic allograft rejection. We propose two key elements within the microenvironment that contribute ...

    • MICROFLUIDIC PLATFORM FOR THE QUANTITATIVE ANALYSIS OF LEUKOCYTE MIGRATION SIGNATURES 

      Boneschansker, Leo; Yan, Jun; Wong, Elisabeth; Briscoe, David M.; Irimia, Daniel (2014)
      Leukocyte migration into tissues is characteristic of inflammation. It is usually measured in vitro as the average displacement of populations of cells towards a chemokine gradient, not acknowledging other patterns of cell ...

    • Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction 

      Zangi, Lior; Lui, Kathy O; von Gise, Alexander; Ma, Qing; Ebina, Wataru; Ptaszek, Leon M.; Später, Daniela; Xu, Huansheng; Tabebordbar, Mohammadsharif; Gorbatov, Rostic; Sena, Brena; Nahrendorf, Matthias; Briscoe, David Michael; Li, Ronald A; Wagers, Amy Jo; Rossi, Derrick J; Pu, William T.; Chien, Kenneth R (Nature Publishing Group, 2013)
      In a cell-free approach to regenerative therapeutics, transient application of paracrine factors in vivo could be used to alter the behavior and fate of progenitor cells to achieve sustained clinical benefits. Here we show ...

    • Regulation of mTOR Signaling by Semaphorin 3F-Neuropilin 2 Interactions In Vitro and In Vivo 

      Nakayama, Hironao; Bruneau, Sarah; Kochupurakkal, Nora; Coma, Silvia; Briscoe, David M.; Klagsbrun, Michael (Nature Publishing Group, 2015)
      Semaphorin 3F (SEMA3F) provides neuronal guidance cues via its ability to bind neuropilin 2 (NRP2) and Plexin A family molecules. Recent studies indicate that SEMA3F has biological effects in other cell types, however its ...