Now showing items 1-5 of 5

    • Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq 

      Venteicher, Andrew S; Tirosh, Itay; Hebert, Christine; Yizhak, Keren; Neftel, Cyril Ralf Alexander; Filbin, Mariella Gruber; Hovestadt, Volker; Escalante, Leah; Shaw, McKenzie; Rodman, Christopher Jiahn-Leh; Gillespie, Shawn; Dionne, Danielle; Luo, Christina; Ravichandran, Hiranmayi; Mylvaganam, Ravindra; Mount, Christopher; Onozato, Maristela Lika; Nahed, Brian Vala; Wakimoto, Hiroaki; Curry, William Thomas; Iafrate, Anthony John; Rivera, Miguel Nicolas; Frosch, Matthew P.; Golub, Todd Robert; Brastianos, Priscilla Kalliope; Getz, Gad A; Patel, Anoop Premswaroop; Monje, Michelle; Cahill, Daniel P.; Rozenblatt-Rosen, Orit; Louis, David N.; Bernstein, Bradley E.; Regev, Aviv; Suvà, Mario (American Association for the Advancement of Science (AAAS), 2017)
    • Insulator dysfunction and oncogene activation in IDH mutant gliomas 

      Flavahan, William A.; Drier, Yotam; Liau, Brian B.; Gillespie, Shawn M.; Venteicher, Andrew S.; Stemmer-Rachamimov, Anat O.; Suvà, Mario L.; Bernstein, Bradley E. (2015)
      Gain-of-function IDH mutations are initiating events that define major clinical and prognostic classes of gliomas1,2. Mutant IDH protein produces a novel onco-metabolite, 2-hydroxyglutarate (2-HG), that interferes with ...
    • Reconstructing and Reprogramming the Tumor-Propagating Potential of Glioblastoma Stem-like Cells 

      Suva, Mario Luca; Rheinbay, Esther; Gillespie, Shawn M.; Patel, Anoop Premswaroop; Wakimoto, Hiroaki; Rabkin, Samuel David; Riggi, Nicolo; Chi, Anthony Wei Shine; Cahill, Daniel P.; Nahed, Brian Vala; Curry, William Thomas; Martuza, Robert Lawrence; Rivera, Miguel Nicolas; Rossetti, Nikki; Kasif, Simon; Beik, Samantha Petrillo; Kadri, Sabah; Tirosh, Itay; Wortman, Ivo; Shalek, Alex K.; Rozenblatt-Rosen, Orit; Regev, Aviv; Louis, David N.; Bernstein, Bradley E. (Elsevier BV, 2014)
      Developmental fate decisions are dictated by master transcription factors (TFs) that interact with cis-regulatory elements to direct transcriptional programs. Certain malignant tumors may also depend on cellular hierarchies ...
    • Resolving Medulloblastoma Cellular Architecture by Single-Cell Genomics 

      Hovestadt, Volker; Goumnerova, Liliana; Sharma, Tanvi; Rusert, Jessica M.; Wechsler-Reya, Robert J.; Li, Xiao-Nan; Peyrl, Andreas; Gojo, Johannes; Kirchhofer, Dominik; Lötsch, Daniela; Czech, Thomas; Dorfer, Christian; Haberler, Christine; Geyeregger, Rene; Halfmann, Angela; Gawad, Charles; Easton, John; Pfister, Stefan M.; Gajjar, Amar; Orr, Brent A.; Slavc, Irene; Robinson, Giles W.; Northcott, Paul A.; Smith, Kyle; Bihannic, Laure; Filbin, Mariella; Shaw, McKenzie; Baumgartner, Alicia; DeWitt, John; Groves, Andrew; Mayr, Lisa; Weisman, Hannah; Richman, Alyssa; Shore, Marni; Carter, Robert; Phoenix, Timothy; Hadley, Jennifer; Tong, Yiai; Rivera, Miguel; Suva, Mario; Houston, Jim; Ashmun, Richard; DeCuypere, Michael; Flasch, Diane; Silkov, Antonina; Bernstein, Bradley; Ligon, Keith; Rozenblatt-Rosen, Orit; Regev, Aviv; Pomeroy, Scott; Rosencrance, Celeste; Baumgartner, Alicia (Springer Science and Business Media LLC, 2019-07-24)
      Medulloblastoma is a malignant childhood cerebellar tumour comprised of distinct molecular subgroups. Whereas genomic characteristics of these subgroups are well defined, the extent to which cellular diversity underlies ...
    • Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma 

      Patel, Anoop Premswaroop; Tirosh, I.; Trombetta, J. J.; Shalek, Alexander Kann; Gillespie, S. M.; Wakimoto, Hiroaki; Cahill, Daniel P.; Nahed, Brian Vala; Curry, William Thomas; Martuza, Robert Lawrence; Louis, David N.; Rozenblatt-Rosen, O.; Suva, Mario Luca; Regev, A.; Bernstein, Bradley E. (American Association for the Advancement of Science (AAAS), 2014)
      Human cancers are complex ecosystems composed of cells with distinct phenotypes, genotypes and epigenetic states, but current models do not adequately reflect tumor composition in patients. We used single cell RNA-seq to ...