Browsing by Author "Chou, James"

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    • Architecture of the Mitochondrial Calcium Uniporter 

      Oxenoid, Kirill; Dong, Ying; Cao, Chan; Cui, Tanxing; Sancak, Yasemin; Markhard, Andrew L.; Grabarek, Zenon; Kong, Liangliang; Liu, Zhijun; Ouyang, Bo; Cong, Yao; Mootha, Vamsi K.; Chou, James J. (2016)
      Mitochondria from multiple, eukaryotic clades uptake and buffer large amounts of calcium (Ca2+) via an inner membrane transporter called the uniporter. Early studies demonstrated that this transport requires a mitochondrial ...

    • Capsid Protein VP4 of Human Rhinovirus Induces Membrane Permeability by the Formation of a Size-Selective Multimeric Pore 

      Panjwani, Anusha; Strauss, Mike; Gold, Sarah; Wenham, Hannah; Jackson, Terry; Chou, James J.; Rowlands, David J.; Stonehouse, Nicola J.; Hogle, James M.; Tuthill, Tobias J. (Public Library of Science, 2014)
      Non-enveloped viruses must deliver their viral genome across a cell membrane without the advantage of membrane fusion. The mechanisms used to achieve this remain poorly understood. Human rhinovirus, a frequent cause of the ...

    • Proton Association Constants of His 37 in the Influenza-A M218–60 Dimer-of-Dimers 

      Colvin, Michael T.; Andreas, Loren B.; Chou, James J.; Griffin, Robert G. (American Chemical Society, 2014)
      The membrane protein M2 from influenza-A forms a single-pass transmembrane helix that assembles in lipid membrane as homotetramers whose primary function is to act as a proton transporter for viral acidification. A single ...

    • Unusual architecture of the p7 channel from hepatitis C virus 

      OuYang, Bo; Xie, Shiqi; Berardi, Marcelo J.; Zhao, Xinhao; Dev, Jyoti; Yu, Wenjing; Sun, Bing; Chou, James J. (2013)
      The Hepatitis C virus (HCV) has developed a small membrane protein, p7, which remarkably can self-assemble into a large channel complex that selectively conducts cations1-4. We are curious as to what structural solution ...