Browsing by Author "Arnaout, Ramy"
Now showing items 1-6 of 6
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Advantages and Limitations of Anticipating Laboratory Test Results from Regression- and Tree-Based Rules Derived from Electronic Health-Record Data
Mohammad, Fahim; Theisen-Toupal, Jesse C.; Arnaout, Ramy (Public Library of Science, 2014)Laboratory testing is the single highest-volume medical activity, making it useful to ask how well one can anticipate whether a given test result will be high, low, or within the reference interval (“normal”). We analyzed ... -
Customized Care 2020: How Medical Sequencing and Network Biology Will Enable Personalized Medicine
Boguski, Mark S.; Arnaout, Ramy; Hill, Colin (Biology Reports Ltd, 2009)Applications of next-generation nucleic acid sequencing technologies will lead to the development of precision diagnostics that will, in turn, be a major technology enabler of precision medicine. Terabyte-scale, multidimensional ... -
The Landscape of Inappropriate Laboratory Testing: A 15-Year Meta-Analysis
Zhi, Ming; Ding, Eric L.; Theisen-Toupal, Jesse; Whelan, Julia; Arnaout, Ramy (Public Library of Science, 2013)Background: Laboratory testing is the single highest-volume medical activity and drives clinical decision-making across medicine. However, the overall landscape of inappropriate testing, which is thought to be dominated ... -
Quantitative deep sequencing reveals dynamic HIV-1 escape and large population shifts during CCR5 antagonist therapy in vivo
Korber, Bette; Russ, Carsten; Lo, Chien-Chi; Leitner, Thomas; Gaschen, Brian; Theiler, James; Paredes, Roger; Su, Zhaohui; Gulick, Roy M.; Greaves, Wayne; Coakley, Eoin; Flexner, Charles; Nusbaum, Chad; Tsibris, Athe Michael Noel; Arnaout, Ramy; Hughes, Michael David; Kuritzkes, Daniel Robert (Public Library of Science, 2009)High-throughput sequencing platforms provide an approach for detecting rare HIV-1 variants and documenting more fully quasispecies diversity. We applied this technology to the V3 loop-coding region of env in samples collected ... -
Robust estimates of overall immune-repertoire diversity from high-throughput measurements on samples
Kaplinsky, Joseph; Arnaout, Ramy (Nature Publishing Group, 2016)The diversity of an organism's B- and T-cell repertoires is both clinically important and a key measure of immunological complexity. However, diversity is hard to estimate by current methods, because of inherent uncertainty ... -
Specificity and Overlap in Gene Segment-defined Antibody Repertoires
Arnaout, Ramy (BioMed Central, 2005)Background: To date several studies have sought to catalog the full suite of antibodies that humans naturally produce against single antigens or other specificities (repertoire). Here we analyze the properties of all ...