Browsing by Author "Norton, Isaiah Hakim"

Now showing items 1-12 of 12

    • Bayesian characterization of uncertainty in intra-subject non-rigid registration 

      Risholm, Petter; Janoos, Firdaus; Norton, Isaiah Hakim; Golby, Alexandra Jacqueline; Wells, William Mercer (Elsevier BV, 2013)
      In settings where high-level inferences are made based on registered image data, the registration uncertainty can contain important information. In this article, we propose a Bayesian non-rigid registration framework where ...

    • A combined fMRI and DTI examination of functional language lateralization and arcuate fasciculus structure: Effects of degree versus direction of hand preference 

      Propper, Ruth E.; O’Donnell, Lauren J.; Whalen, Stephen; Tie, Yanmei; Norton, Isaiah Hakim; Suarez, Ralph O.; Zollei, Lilla; Radmanesh, Alireza; Golby, Alexandra Jacqueline (Elsevier BV, 2010)
      The present study examined the relationship between hand preference degree and direction, functional language lateralization in Broca’s and Wernicke’s areas, and structural measures of the arcuate fasciculus. Results ...

    • Defining language networks from resting-state fMRI for surgical planning-a feasibility study 

      Tie, Yanmei; Rigolo, Laura; Norton, Isaiah Hakim; Huang, Raymond Y; Wu, Wentao; Orringer, Daniel; Mukundan, Srinivasan; Golby, Alexandra Jacqueline (Wiley-Blackwell, 2013)
      Presurgical language mapping for patients with lesions close to language areas is critical to neurosurgical decision-making for preservation of language function. As a clinical noninvasive imaging technique, functional MRI ...

    • Development of Stereotactic Mass Spectrometry for Brain Tumor Surgery 

      Agar, Nathalie Marie Yvonne Rachel; Golby, Alexandra Jacqueline; Ligon, Keith Lloyd; Norton, Isaiah Hakim; Mohan, Vandana; Wiseman, Justin M; Tannenbaum, Allen; Jolesz, Ferenc A. (Oxford University Press (OUP), 2011)
      BACKGROUND: Surgery remains the first and most important treatment modality for the majority of solid tumors. Across a range of brain tumor types and grades, postoperative residual tumor has a great impact on prognosis. ...

    • The Fiber Laterality Histogram: A New Way to Measure White Matter Asymmetry 

      O’Donnell, Lauren J.; Westin, Carl-Fredrik; Norton, Isaiah Hakim; Whalen, Stephen; Rigolo, Laura; Propper, Ruth; Golby, Alexandra Jacqueline (Springer Berlin Heidelberg, 2010)
      The quantification of brain asymmetries may provide biomarkers for presurgical localization of language function and can improve our understanding of neural structure-function relationships in health and disease. We propose ...

    • Interactive Diffusion Tensor Tractography Visualization for Neurosurgical Planning 

      Golby, Alexandra Jacqueline; Kindlmann, Gordon; Norton, Isaiah Hakim; Yarmarkovich, Alexander; Pieper, Steven; Kikinis, Ron (Oxford University Press (OUP), 2011)
      BACKGROUND: Diffusion tensor imaging (DTI) infers the trajectory and location of large white matter tracts by measuring the anisotropic diffusion of water. DTI data may then be analyzed and presented as tractography for ...

    • Intraoperative Real-Time Querying of White Matter Tracts During Frameless Stereotactic Neuronavigation 

      Elhawary, Haytham; Liu, Haiying; Patel, Pratik; Norton, Isaiah Hakim; Rigolo, Laura; Papademetris, Xenophon; Hata, Nobuhiko; Golby, Alexandra Jacqueline (Oxford University Press (OUP), 2011)
      BACKGROUND: Brain surgery faces important challenges when trying to achieve maximum tumor resection while avoiding postoperative neurological deficits. OBJECTIVE: For surgeons to have optimal intraoperative information ...

    • Molecular imaging of drug transit through the blood-brain barrier with MALDI mass spectrometry imaging 

      Liu, Xiaohui; Ide, Jennifer L.; Norton, Isaiah; Marchionni, Mark A.; Ebling, Maritza C.; Wang, Lan Y.; Davis, Erin; Sauvageot, Claire M.; Kesari, Santosh; Kellersberger, Katherine A.; Easterling, Michael L.; Santagata, Sandro; Stuart, Darrin D.; Alberta, John; Agar, Jeffrey N.; Stiles, Charles D.; Agar, Nathalie Y. R. (Nature Publishing Group, 2013)
      Drug transit through the blood-brain barrier (BBB) is essential for therapeutic responses in malignant glioma. Conventional methods for assessment of BBB penetrance require synthesis of isotopically labeled drug derivatives. ...

    • Rapid, Label-Free Detection of Brain Tumors with Stimulated Raman Scattering Microscopy 

      Ji, Minbiao; Orringer, Daniel A.; Freudiger, Christian Wilhelm; Ramkissoon, Shakti; Liu, Xiaohui; Lau, Darryl; Golby, Alexandra Jacqueline; Norton, Isaiah Hakim; Hayashi, Marika; Agar, Nathalie Marie Yvonne Rachel; Young, Geoffrey; Spino, Cathie; Santagata, Sandro; Camelo-Piragua, Sandra; Ligon, Keith Lloyd; Sagher, Oren; Xie, Xiaoliang Sunney (American Association for the Advancement of Science (AAAS), 2013)
      Surgery is an essential component in the treatment of brain tumors. However, delineating tumor from normal brain remains a major challenge. We describe the use of stimulated Raman scattering (SRS) microscopy for ...

    • Reconstruction of the arcuate fasciculus for surgical planning in the setting of peritumoral edema using two-tensor unscented Kalman filter tractography 

      Chen, Zhenrui; Tie, Yanmei; Olubiyi, Olutayo; Rigolo, Laura; Mehrtash, Alireza; Norton, Isaiah; Pasternak, Ofer; Rathi, Yogesh; Golby, Alexandra J.; O'Donnell, Lauren J. (Elsevier, 2015)
      Background: Diffusion imaging tractography is increasingly used to trace critical fiber tracts in brain tumor patients to reduce the risk of post-operative neurological deficit. However, the effects of peritumoral edema ...

    • Special Surgical Considerations for Functional Brain Mapping 

      Kekhia, Hussein; Rigolo, Laura; Norton, Isaiah Hakim; Golby, Alexandra Jacqueline (Elsevier BV, 2011)
      The development of functional mapping techniques gives neurosurgeons many options for preoperative planning. Integrating functional and anatomic data can inform patient selection and surgical planning and makes functional ...

    • Visual Pathway Study Using In Vivo Diffusion Tensor Imaging Tractography to Complement Classic Anatomy 

      Wu, Wentao; Rigolo, Laura; O'Donnell, Lauren Jean; Norton, Isaiah; Shriver, Sargent; Golby, Alexandra Jacqueline (Oxford University Press (OUP), 2012)
      BACKGROUND: Knowledge of the individual course of the optic radiations (ORs) is important to avoid postoperative visual deficits. Cadaveric studies of the visual pathways are limited because it has not been possible to ...