Browsing by Author "Cernadas, Manuela"
Now showing items 1-5 of 5
-
Adam8 Limits the Development of Allergic Airway Inflammation in Mice
Knolle, M. D.; Nakajima, T.; Hergrueter, A.; Gupta, K.; Polverino, Francesca; Craig, V; Fyfe, S. E.; Zahid, M.; Permaul, Perdita; Cernadas, Manuela; Montano, Giancarlo Vengco; Tesfaigzi, Y.; Sholl, Lynette Marie; Kobzik, Lester; Israel, Elliot; Owen, Caroline Ann (The American Association of Immunologists, 2013)To determine whether a disintegrin and a metalloproteinase-8 (Adam8) regulates allergic airway inflammation (AAI) and airway hyper-responsiveness (AHR), we compared AAI and AHR in wild type (WT) versus Adam8−/− mice in ... -
Integrating Murine Gene Expression Studies to Understand Obstructive Lung Disease due to Chronic Inhaled Endotoxin
Lai, Peggy Sue; Hofmann, Oliver Marc; Baron, Rebecca Marlene; Cernadas, Manuela; Meng, Quanxin Ryan; Bresler, Herbert S.; Brass, David M.; Yang, Ivana V.; Schwartz, David A.; Christiani, David C.; Hide, Winston (Public Library of Science, 2013)Rationale: Endotoxin is a near ubiquitous environmental exposure that that has been associated with both asthma and chronic obstructive pulmonary disease (COPD). These obstructive lung diseases have a complex pathophysiology, ... -
Lipoxin A4 Regulates Natural Killer Cell and Type 2 Innate Lymphoid Cell Activation in Asthma
Barnig, Cindy; Cernadas, Manuela; Dutile, Stefanie; Liu, Xiaoli; Perrella, Mark; Kazani, Shamsah; Wechsler, Michael E.; Israel, Elliot; Levy, Bruce (American Association for the Advancement of Science (AAAS), 2013-02-27)Asthma is a prevalent disease of chronic inflammation in which endogenous counter-regulatory signaling pathways are dysregulated. Recent evidence suggests that innate lymphoid cells (ILCs), including natural killer (NK) ... -
PTPN22.6, a Dominant Negative Isoform of PTPN22 and Potential Biomarker of Rheumatoid Arthritis
Chang, Hui-Hsin; Tai, Tzong-Shyuan; Lu, Bing; Iannaccone, Christine; Cernadas, Manuela; Weinblatt, Michael Elliott; Shadick, Nancy Ann; Miaw, Shi-Chuen; Ho, I-Cheng (Public Library of Science, 2012)PTPN22 is a tyrosine phosphatase and functions as a damper of TCR signals. A C-to-T single nucleotide polymorphism (SNP) located at position 1858 of human PTPN22 cDNA and converting an arginine (R620) to tryptophan (W620) ... -
Vitamin D3 Treatment of Vitamin D–insufficient Asthmatic Patients Does Not Alter Immune Cell Function
Reid, Brandy; Girodet, Pierre-Olivier; Boomer, Jonathan S.; Abdel-Gadir, Azza; Zheng, Kathy; Wechsler, Michael; Bacharier, Leonard B.; Kunselman, Susan J.; King, Tonya S.; Israel, Elliot; Castro, Mario; Cernadas, Manuela; Green, Jonathan M. (Elsevier BV, 2016-07)