Now showing items 1-3 of 3

    • Adam8 Limits the Development of Allergic Airway Inflammation in Mice 

      Knolle, M. D.; Nakajima, T.; Hergrueter, A.; Gupta, K.; Polverino, Francesca; Craig, V; Fyfe, S. E.; Zahid, M.; Permaul, Perdita; Cernadas, Manuela; Montano, Giancarlo Vengco; Tesfaigzi, Y.; Sholl, Lynette Marie; Kobzik, Lester; Israel, Elliot; Owen, Caroline Ann (The American Association of Immunologists, 2013)
      To determine whether a disintegrin and a metalloproteinase-8 (Adam8) regulates allergic airway inflammation (AAI) and airway hyper-responsiveness (AHR), we compared AAI and AHR in wild type (WT) versus Adam8−/− mice in ...
    • Integrating Murine Gene Expression Studies to Understand Obstructive Lung Disease due to Chronic Inhaled Endotoxin 

      Lai, Peggy Sue; Hofmann, Oliver Marc; Baron, Rebecca Marlene; Cernadas, Manuela; Meng, Quanxin Ryan; Bresler, Herbert S.; Brass, David M.; Yang, Ivana V.; Schwartz, David A.; Christiani, David C.; Hide, Winston (Public Library of Science, 2013)
      Rationale: Endotoxin is a near ubiquitous environmental exposure that that has been associated with both asthma and chronic obstructive pulmonary disease (COPD). These obstructive lung diseases have a complex pathophysiology, ...
    • PTPN22.6, a Dominant Negative Isoform of PTPN22 and Potential Biomarker of Rheumatoid Arthritis 

      Chang, Hui-Hsin; Tai, Tzong-Shyuan; Lu, Bing; Iannaccone, Christine; Cernadas, Manuela; Weinblatt, Michael Elliott; Shadick, Nancy Ann; Miaw, Shi-Chuen; Ho, I-Cheng (Public Library of Science, 2012)
      PTPN22 is a tyrosine phosphatase and functions as a damper of TCR signals. A C-to-T single nucleotide polymorphism (SNP) located at position 1858 of human PTPN22 cDNA and converting an arginine (R620) to tryptophan (W620) ...