Now showing items 1-20 of 25

    • Childhood infections and asthma: at the crossroads of the hygiene and Barker hypotheses 

      Tantisira, Kelan; Weiss, Scott Tillman (BioMed Central, 2001)
      The hygiene hypothesis states that childhood asthma develops as a result of decreased exposure to infectious agents during infancy and early childhood. This results in the persistence of the neonatal T helper lymphocyte 2 ...
    • Circulating MicroRNAs: Association with Lung Function in Asthma 

      Kho, Alvin T.; Sharma, Sunita; Davis, Joshua S.; Spina, Joseph; Howard, Dagnie; McEnroy, Kevin; Moore, Kip; Sylvia, Jody; Qiu, Weiliang; Weiss, Scott T.; Tantisira, Kelan G. (Public Library of Science, 2016)
      Background: MicroRNAs are key transcriptional and network regulators previously associated with asthma susceptibility. However, their role in relation to asthma severity has not been delineated. Objective: We hypothesized ...
    • CMTR1 is associated with increased asthma exacerbations in patients taking inhaled corticosteroids 

      Dahlin, Amber; Denny, Joshua; Roden, Dan M.; Brilliant, Murray H.; Ingram, Christie; Kitchner, Terrie E.; Linneman, James G.; Shaffer, Christian M.; Weeke, Peter; Xu, Hua; Kubo, Michiaki; Tamari, Mayumi; Clemmer, George L.; Ziniti, John; McGeachie, Michael J.; Tantisira, Kelan G.; Weiss, Scott T.; Wu, Ann Chen (John Wiley and Sons Inc., 2015)
      Abstract Inhaled corticosteroids (ICS) are the most effective controller medications for asthma, and variability in ICS response is associated with genetic variation. Despite ICS treatment, some patients with poor asthma ...
    • Diagnostic accuracy of the bronchodilator response in children 

      Tse, Szewah; Gold, Diane R.; Sordillo, Joanne; Hoffman, Elaine; Gillman, Matthew William; Rifas-Shiman, Sheryl Lynn; Fuhlbrigge, Anne Louise; Tantisira, Kelan; Weiss, Scott Tillman; Litonjua, Augusto Ampil (Elsevier BV, 2013)
      Background: The bronchodilator response (BDR) reflects the reversibility of airflow obstruction and is recommended as an adjunctive test to diagnose asthma. The validity of the commonly used definition of BDR, a 12% or ...
    • Expression analysis of asthma candidate genes during human and murine lung development 

      Melén, Erik; Kho, Alvin Thong-Juak; Sharma, Sunita; Gaedigk, Roger; Leeder, J Steven; Mariani, Thomas J; Carey, Vincent James; Weiss, Scott Tillman; Tantisira, Kelan (Springer Science + Business Media, 2011)
      Background: Little is known about the role of most asthma susceptibility genes during human lung development. Genetic determinants for normal lung development are not only important early in life, but also for later lung ...
    • Genome-Wide Association Analysis in Asthma Subjects Identifies SPATS2L as a Novel Bronchodilator Response Gene 

      Himes, Blanca Elena; Jiang, Xiaofeng; Hu, Ruoxi; Wu, Ann Chen; Su, Jessica Ann Lasky; Klanderman, Barbara J.; Ziniti, John; Senter-Sylvia, Jody; Lima, John J.; Irvin, Charles G.; Peters, Stephen P.; Meyers, Deborah A.; Bleecker, Eugene R.; Kubo, Michiaki; Tamari, Mayumi; Nakamura, Yusuke; Szefler, Stanley J.; Lemanske, Robert F.; Zeiger, Robert S.; Strunk, Robert C.; Martinez, Fernando D.; Hanrahan, John P.; Koppelman, Gerard H.; Postma, Dirkje S.; Nieuwenhuis, Maartje A. E.; Vonk, Judith M.; Panettieri, Reynold A.; Markezich, Amy; Israel, Elliot; Carey, Vincent James; Tantisira, Kelan; Litonjua, Augusto Ampil; Lu, Quan; Weiss, Scott Tillman (Public Library of Science, 2012)
      Bronchodilator response (BDR) is an important asthma phenotype that measures reversibility of airway obstruction by comparing lung function (i.e. FEV1) before and after the administration of a short-acting β2-agonist, the ...
    • Genome-Wide Association Study Identifies Novel Pharmacogenomic Loci For Therapeutic Response to Montelukast in Asthma 

      Dahlin, Amber; Litonjua, Augusto; Lima, John J.; Tamari, Mayumi; Kubo, Michiaki; Irvin, Charles G.; Peters, Stephen P.; Tantisira, Kelan G. (Public Library of Science, 2015)
      Background: Genome-wide association study (GWAS) is a powerful tool to identify novel pharmacogenetic single nucleotide polymorphisms (SNPs). Leukotriene receptor antagonists (LTRAs) are a major class of asthma medications, ...
    • Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population 

      Hirota, Tomomitsu; Takahashi, Atsushi; Kubo, Michiaki; Tsunoda, Tatsuhiko; Tomita, Kaori; Doi, Satoru; Fujita, Kimie; Miyatake, Akihiko; Enomoto, Tadao; Miyagawa, Takehiko; Adachi, Mitsuru; Tanaka, Hiroshi; Niimi, Akio; Matsumoto, Hisako; Ito, Isao; Masuko, Hironori; Sakamoto, Tohru; Hizawa, Nobuyuki; Taniguchi, Masami; Lima, John J; Irvin, Charles G; Peters, Stephen P; Himes, Blanca; Litonjua, Augusto Ampil; Tantisira, Kelan; Weiss, Scott Tillman; Kamatani, Naoyuki; Nakamura, Yusuke; Tamari, Mayumi (Nature Publishing Group, 2011)
    • A genome-wide association study of bronchodilator response in asthmatics 

      Duan, Q; Lasky-Su, Jessica A. Lasky; Himes, Blanca; Qiu, Weiliang; Litonjua, Augusto Ampil; Damask, Amy; Lazarus, Richard James; Klanderman, Barbara; Irvin, Charles G.; Peters, Stephen P; Hanrahan, John P; Lima, John J.; Martinez, Fernando D.; Mauger, David; Chinchilli, Vernon M.; Soto-Quiros, Manuel; Avila, Lydiana; Celedón, Juan C.; Lange, Christoph; Weiss, Scott Tillman; Tantisira, Kelan (Nature Publishing Group, 2013)
      Reversibility of airway obstruction in response to β2-agonists is highly variable among asthmatics, which is partially attributed to genetic factors. In a genome-wide association study of acute bronchodilator response (BDR) ...
    • Genome-wide association study of the age of onset of childhood asthma 

      Forno, Erick; Lasky-Su, Jessica A. Lasky; Himes, Blanca; Howrylak, Judie; Ramsey, Clare; Brehm, John; Klanderman, Barbara; Ziniti, John; Melén, Erik; Pershagen, Goran; Wickman, Magnus; Martinez, Fernando; Mauger, Dave; Sorkness, Christine; Tantisira, Kelan; Raby, Benjamin Alexander; Weiss, Scott Tillman; Celedón, Juan C. (Elsevier BV, 2012)
      BACKGROUND: Childhood asthma is a complex disease with known heritability and phenotypic diversity. Although an earlier onset has been associated with more severe disease, there has been no genome-wide association study ...
    • Genome-wide association study reveals class I MHC–restricted T cell–associated molecule gene (CRTAM) variants interact with vitamin D levels to affect asthma exacerbations 

      Du, Rose; Litonjua, Augusto Ampil; Tantisira, Kelan; Lasky-Su, Jessica A. Lasky; Sunyaev, Shamil R.; Klanderman, Barbara; Celedón, Juan C.; Avila, Lydiana; Soto-Quiros, Manuel E.; Weiss, Scott Tillman (Elsevier BV, 2012)
      Background— It has recently been shown that vitamin D deficiency can increase asthma development and severity and that variations in vitamin D receptor genes are associated with asthma susceptibility. Objective— We sought ...
    • Genomewide association between GLCCI1 and response to glucocorticoid therapy in asthma 

      Tantisira, Kelan; Lasky-Su, Jessica A. Lasky; Harada, Michishige; Murphy, Amy; Litonjua, Augusto Ampil; Himes, Blanca; Lange, Christoph; Lazarus, Ross; Sylvia, Jody; Klanderman, Barbara; Duan, Qing Ling; Qiu, Weiliang; Hirota, Tomomitsu; Martinez, Fernando D.; Mauger, David; Sorkness, Christine; Szefler, Stanley; Lazarus, Stephen C.; Lemanske, Robert F.; Peters, Stephen P.; Lima, John J.; Nakamura, Yusuke; Tamari, Mayumi; Weiss, Scott Tillman (New England Journal of Medicine (NEJM/MMS), 2011)
      Background: The response to treatment for asthma is characterized by wide interindividual variability, with a significant number of patients who have no response. We hypothesized that a genomewide association study would ...
    • The genomic origins of asthma 

      Sharma, Sunita; Chhabra, Divya; Kho, Alvin Thong-Juak; Hayden, Lystra P.; Tantisira, Kelan; Weiss, Scott Tillman (BMJ, 2014)
      Lung function tracks from the earliest age that it can be reliably measured. Genome wide association studies (GWAS) suggest that most variants identified for common complex traits are both regulatory in function and active ...
    • Importin-13 genetic variation is associated with improved airway responsiveness in childhood asthma 

      Raby, Benjamin Alexander; Van Steen, Kristel; Su, Jessica Ann Lasky; Tantisira, Kelan; Kaplan, Feige; Weiss, Scott Tillman (BioMed Central, 2009)
      Background: Glucocorticoid function is dependent on efficient translocation of the glucocorticoid receptor (GR) from the cytoplasm to the nucleus of cells. Importin-13 (IPO13) is a nuclear transport receptor that mediates ...
    • Inhaled corticosteroid treatment modulates ZNF432 gene variant’s effect on bronchodilator response in asthmatics 

      Wu, Ann Chen; Himes, Blanca; Lasky-Su, Jessica A. Lasky; Litonjua, Augusto Ampil; Peters, Stephen P.; Lima, John; Kubo, Michiaki; Tamari, Mayumi; Nakamura, Yusuke; Qiu, Weiliang; Weiss, Scott Tillman; Tantisira, Kelan (Elsevier BV, 2014)
      Background: Single nucleotide polymorphisms (SNPs) influence a patient's response to inhaled corticosteroids and β2-agonists, and the effect of treatment with inhaled corticosteroids is synergistic with the effect of ...
    • Integration of Mouse and Human Genome-Wide Association Data Identifies KCNIP4 as an Asthma Gene 

      Sheppard, Keith; Berndt, Annerose; Leme, Adriana S.; Myers, Rachel A.; Gignoux, Christopher R.; Gauderman, W. James; Yang, James J.; Mathias, Rasika A.; Romieu, Isabelle; Torgerson, Dara G.; Roth, Lindsey A.; Huntsman, Scott; Eng, Celeste; Klanderman, Barbara; Ziniti, John; Senter-Sylvia, Jody; Szefler, Stanley J.; Lemanske, Robert F.; Zeiger, Robert S.; Strunk, Robert C.; Martinez, Fernando D.; Boushey, Homer; Chinchilli, Vernon M.; Mauger, David; Koppelman, Gerard H.; Postma, Dirkje S.; Nieuwenhuis, Maartje A. E.; Vonk, Judith M.; Lima, John J.; Irvin, Charles G.; Peters, Stephen P.; Kubo, Michiaki; Tamari, Mayumi; Nakamura, Yusuke; Bleecker, Eugene R.; Meyers, Deborah A.; London, Stephanie J.; Gilliland, Frank D.; Burchard, Esteban G.; Nicolae, Dan L.; Ober, Carole; Paigen, Beverly; Churchill, Gary; Himes, Blanca Elena; Levin, Albert M.; Israel, Elliot; Litonjua, Augusto Ampil; Tantisira, Kelan; Raby, Benjamin Alexander; Barnes, Kathleen C.; Williams, L. Keoki; Demeo, Dawn Lisa; Silverman, Edwin Kepner; Shapiro, Steve D.; Weiss, Scott Tillman (Public Library of Science, 2013)
      Asthma is a common chronic respiratory disease characterized by airway hyperresponsiveness (AHR). The genetics of asthma have been widely studied in mouse and human, and homologous genomic regions have been associated with ...
    • Patterns of Growth and Decline in Lung Function in Persistent Childhood Asthma 

      McGeachie, Michael John; Yates, Katherine; Zhou, Xiaobo; Guo, Feng; Sternberg, Alice L.; Van Natta, Mark L.; Wise, Robert A.; Szefler, Stanley J.; Sharma, Sunita; Kho, Alvin Thong-Juak; Cho, Michael Hyosang; Croteau-Chonka, Damien C; Castaldi, Peter Jose; Jain, Gaurav; Sanyal, Amartya; Zhan, Ye; Lajoie, Bryan R.; Dekker, Job; Stamatoyannopoulos, John; Covar, Ronina A.; Zeiger, Robert S.; Adkinson, N. Franklin; Williams, Paul; Kelly, H. William; Grasemann, Hartmut; Vonk, Judith M.; Koppelman, Gerard H.; Postma, Dirkje S.; Raby, Benjamin Alexander; Houston, Isaac Benjamin; Lu, Quan; Fuhlbrigge, Anne Louise; Tantisira, Kelan; Silverman, Edwin Kepner; Tonascia, James; Weiss, Scott Tillman; Strunk, Robert C. (New England Journal of Medicine (NEJM/MMS), 2016)
      BACKGROUND: Tracking longitudinal measurements of growth and decline in lung function in patients with persistent childhood asthma may reveal links between asthma and subsequent chronic airflow obstruction. METHODS: We ...
    • The pharmacogenetics and pharmacogenomics of asthma therapy 

      Tse, Sze Man; Tantisira, Kelan; Weiss, Scott Tillman (Nature Publishing Group, 2011)
      Despite the availability of several classes of asthma medications and their overall effectiveness, a significant portion of patients fail to respond to these therapeutic agents. Evidence suggests that genetic factors may ...
    • Platform dependence of inference on gene-wise and gene-set involvement in human lung development 

      Bhattacharya, Soumyaroop; Metje, Stephanie; Gaedigk, Roger; Mariani, Thomas J; Leeder, J Steven; Du, Rose; Tantisira, Kelan; Carey, Vincent James; Kho, Alvin Thong-Juak; Klanderman, Barbara Jordan; Lazarus, Ross; Weiss, Scott Tillman (BioMed Central, 2009)
      Background: With the recent development of microarray technologies, the comparability of gene expression data obtained from different platforms poses an important problem. We evaluated two widely used platforms, Affymetrix ...
    • Polymorphisms in Signal Transducer and Activator of Transcription 3 and Lung Function in Asthma 

      Litonjua, Augusto Ampil; Tantisira, Kelan; Lake, Stephen; Lazarus, Ross; Richter, Brent G; Gabriel, Stacey; Silverman, Eric S; Weiss, Scott Tillman (BioMed Central, 2005)
      Background: Identifying genetic determinants for lung function is important in providing insight into the pathophysiology of asthma. Signal transducer and activator of transcription 3 is a transcription factor latent in ...