Now showing items 1-20 of 30

    • Abdominal Superficial Subcutaneous Fat 

      Golan, Rachel; Shelef, Ilan; Rudich, Assaf; Gepner, Yftach; Shemesh, Elad; Chassidim, Yoash; Harman-Boehm, Ilana; Henkin, Yaakov; Schwarzfuchs, Dan; Ben Avraham, Sivan; Witkow, Shula; Liberty, Idit F.; Tangi-Rosental, Osnat; Sarusi, Benjamin; Stampfer, Meir Jonathan; Shai, Iris (American Diabetes Association, 2012)
      OBJECTIVE: Unlike visceral adipose tissue (VAT), the association between subcutaneous adipose tissue (SAT) and obesity-related morbidity is controversial. In patients with type 2 diabetes, we assessed whether this variability ...
    • Analysis of the 10q11 Cancer Risk Locus Implicates MSMB and NCOA4 in Human Prostate Tumorigenesis 

      Chanock, Stephen J.; Schafer, Eric J.; Tabernero, Josep; Baselga, José; Oh, William K.; Pomerantz, Mark M; Shrestha, Yashaswi; Flavin, Richard John; Regan, Meredith Margaret; Penney, Kathryn Lee; Mucci, Lorelei Ann; Stampfer, Meir Jonathan; Hunter, David J.; Chan, Jennifer Ang; Richardson, Andrea Lynn; Loda, Massimo; Kantoff, Philip Wayne; Hahn, William C.; Freedman, Matthew Lawrence (Public Library of Science, 2010)
      Genome-wide association studies (GWAS) have established a variant, rs10993994, on chromosome 10q11 as being associated with prostate cancer risk. Since the variant is located outside of a protein-coding region, the target ...
    • Apolipoprotein(a) Size and Lipoprotein(a) Concentration and Future Risk of Angina Pectoris with Evidence of Severe Coronary Atherosclerosis in Men: The Physicians' Health Study 

      Rifai, Nader; Ma, Jing; Sacks, Frank Martin; Ridker, Paul M.; Hernandez, W; Stampfer, Meir Jonathan; Marcovina, S (American Association for Clinical Chemistry (AACC), 2004)
      The relationship of lipoprotein (a) [Lp(a)] concentrations with risk of coronary heart disease needs clarification, especially for threshold values for increased risk and for possible interactions with LDL-cholesterol ...
    • Association of Nut Consumption with Total and Cause-Specific Mortality 

      Bao, Ying; Han, Jiali; Hu, Frank B.; Giovannucci, Edward L.; Stampfer, Meir Jonathan; Willett, Walter C.; Fuchs, Charles Stewart (New England Journal of Medicine (NEJM/MMS), 2013)
      BACKGROUND: Increased nut consumption has been associated with a reduced risk of major chronic diseases, including cardiovascular disease and type 2 diabetes mellitus. However, the association between nut consumption and ...
    • CETP genotype and changes in lipid levels in response to weight-loss diet intervention in the POUNDS LOST and DIRECT randomized trials 

      Qi, Qibin; Durst, Ronen; Schwarzfuchs, Dan; Leitersdorf, Eran; Shpitzen, Shoshi; Li, Yanping; Wu, Hongyu; Champagne, Catherine M.; Hu, Frank B.; Stampfer, Meir Jonathan; Bray, George A.; Sacks, Frank Martin; Shai, Iris; Qi, Lu (American Society for Biochemistry & Molecular Biology (ASBMB), 2014)
      Little is known about whether cholesteryl ester transfer protein (CETP) genetic variation may modify the effect of weight-loss diets varying in fat content on changes in lipid levels. We analyzed the interaction between ...
    • Circulating Fatty Acids and Prostate Cancer Risk: Individual Participant Meta-Analysis of Prospective Studies 

      Crowe, Francesca L.; Appleby, Paul N.; Travis, Ruth C.; Barnett, Matt; Brasky, Theodore M.; Bueno-de-Mesquita, H. Bas; Chajes, Veronique; Chavarro, Jorge E.; Chirlaque, Maria-Dolores; English, Dallas R.; Gibson, Robert A.; Giles, Graham G.; Goodman, Gary E.; Henning, Susanne M.; Kaaks, Rudolf; King, Irena B.; Kolonel, Lawrence N.; Kristal, Alan R.; Neuhouser, Marian L.; Park, Song-Yi; Severi, Gianluca; Siddiq, Afshan; Stampfer, Meir J.; Stattin, Pär; Tangen, Catherine M.; Tjønneland, Anne; Trichopoulos, Dimitrios; Tumino, Rosario; Wilkens, Lynne R.; Key, Timothy J.; Allen, Naomi E. (Oxford University Press, 2014)
      Background: Individual studies have suggested that some circulating fatty acids are associated with prostate cancer risk, but have not been large enough to provide precise estimates of associations, particularly by stage ...
    • Consumption of Fish Products across the Lifespan and Prostate Cancer Risk 

      Torfadottir, Johanna E.; Valdimarsdottir, Unnur; Mucci, Lorelei Ann; Kasperzyk, Julie L.; Fall, Katja; Tryggvadottir, Laufey; Aspelund, Thor; Olafsson, Orn; Harris, Tamara B.; Jonsson, Eirikur; Tulinius, Hrafn; Gudnason, Vilmundur; Adami, Hans-Olov; Stampfer, Meir Jonathan; Steingrimsdottir, Laufey (Public Library of Science, 2013)
      Objective: To examine whether fish and fish oil consumption across the lifespan is associated with a lower risk of prostate cancer. Design: The study was nested among 2268 men aged 67–96 years in the AGES-Reykjavik cohort ...
    • Dietary Fat Intake and Cognitive Decline in Women With Type 2 Diabetes 

      Devore, Elizabeth Ellen; Stampfer, Meir Jonathan; Breteler, Monique M.; Rosner, Bernard Alfred; Kang, Jae Hee Hee; Okereke, Olivia Ifeoma; Hu, Frank B.; Grodstein, Francine (American Diabetes Association, 2009)
      OBJECTIVE: Individuals with type 2 diabetes have high risk of late-life cognitive impairment, yet little is known about strategies to modify risk. Targeting insulin resistance and vascular complications—both associated ...
    • Elevated circulating branched chain amino acids are an early event in pancreatic adenocarcinoma development 

      Mayers, Jared R.; Wu, Chen; Clish, Clary B.; Kraft, Peter; Torrence, Margaret E.; Fiske, Brian P.; Yuan, Chen; Bao, Ying; Townsend, Mary K.; Tworoger, Shelley S.; Davidson, Shawn M.; Papagiannakopoulos, Thales; Yang, Annan; Dayton, Talya L.; Ogino, Shuji; Stampfer, Meir J.; Giovannucci, Edward L.; Qian, Zhi Rong; Rubinson, Douglas A.; Ma, Jing; Sesso, Howard D.; Gaziano, John Michael; Cochrane, Barbara B.; Liu, Simin; Wactawski–Wende, Jean; Manson, JoAnn E.; Pollak, Michael N.; Kimmelman, Alec C.; Souza, Amanda; Pierce, Kerry; Wang, Thomas J.; Gerszten, Robert E.; Fuchs, Charles S.; Heiden, Matthew G. Vander; Wolpin, Brian M. (2014)
      Most patients with pancreatic ductal adenocarcinoma (PDAC) are diagnosed with advanced disease and survive less than 12 months1. PDAC has been linked with obesity and glucose intolerance2-4, but whether changes in circulating ...
    • Genetic Variation in the HSD17B1 Gene and Risk of Prostate Cancer 

      Kraft, Peter; Pharoah, Paul; Chanock, Stephen J; Albanes, Demetrius; Kolonel, Laurence N; Hayes, Richard B; Andriole, Gerald; Berg, Christine; Boeing, Heiner; Burtt, Noel P; Bueno-de-Mesquita, Bas; Calle, Eugenia E; Cann, Howard; Canzian, Federico; Crawford, David E; Dunning, Alison M; Feigelson, Heather S; Gonzalez, Carlos Alberto; Haiman, Christopher A; Hallmans, Goran; Henderson, Brian E; Kaaks, Rudolf; Key, Timothy; Marchand, Loic Le; Overvad, Kim; Palli, Domenico; Pike, Malcolm C; Riboli, Elio; Rodriguez, Carmen; Setiawan, Wendy V; Stram, Daniel O; Thomas, Gilles; Thun, Michael J; Travis, Ruth; Trichopoulou, Antonia; Virtamo, Jarmo; Wacholder, Sholom; Altshuler, David Matthew; Chen, Yin-Ching Iris; Freedman, Matthew Lawrence; Gaziano, John Michael; Giovannucci, Edward L.; Hirschhorn, Joel Naom; Hunter, David J.; Ma, Jing; Stampfer, Meir Jonathan (Public Library of Science, 2005)
      Steroid hormones are believed to play an important role in prostate carcinogenesis, but epidemiological evidence linking prostate cancer and steroid hormone genes has been inconclusive, in part due to small sample sizes ...
    • Germline Variation in Superoxide Dismutase-2 (SOD2) and Survival Outcomes after Radiation Therapy for Prostate Cancer: Results from a Test and Validation Set Analysis 

      Margalit, Danielle N.; Jordahl, Kristina M.; Werner, Lillian; Wang, Xiaodong; Lee, Mary Gwo-Shu; Penney, Kathryn L.; Batista, Julie L.; Martin, Neil E.; Chan, June M.; Kantoff, Philip W.; Stampfer, Meir J.; Nguyen, Paul L.; Mucci, Lorelei A. (2016)
      Background: Genetic variants in antioxidant pathways may decrease the efficacy of radiation therapy (RT) by suppressing the generation of reactive oxygen species (ROS). We studied the association between single nucleotide ...
    • Healthy Lifestyle and Leukocyte Telomere Length in U.S. Women 

      Sun, Qi; Shi, Ling; Prescott, Jennifer; Chiuve, Stephanie Elizabeth; Hu, Frank B.; De Vivo, Immaculata; Stampfer, Meir Jonathan; Franks, Paul W.; Manson, JoAnn Elisabeth; Rexrode, Kathryn Marian (Public Library of Science, 2012)
      Context: Whether a healthy lifestyle may be associated with longer telomere length is largely unknown. Objectives: To examine healthy lifestyle practices, which are primary prevention measures against major age-related ...
    • Immediate Risk for Cardiovascular Events and Suicide Following a Prostate Cancer Diagnosis: Prospective Cohort Study 

      Ye, Weimin; Andrén, Ove; Johansson, Jan-Erik; Andersson, Swen-Olof; Sparén, Pär; Klein, Georg; Valdimarsdóttir, Unnur; Franco, Eduardo L.; Fall, Katja; Fang, Fang; Mucci, Lorelei Ann; Stampfer, Meir Jonathan; Adami, Hans-Olov (Public Library of Science, 2009)
      Background: Stressful life events have been shown to be associated with altered risk of various health consequences. The aim of the present study was to investigate whether the emotional stress evoked by a prostate cancer ...
    • Light to moderate intake of alcohol, drinking patterns, and risk of cancer: results from two prospective US cohort studies 

      Cao, Yin; Willett, Walter C; Rimm, Eric B; Stampfer, Meir J; Giovannucci, Edward L (BMJ Publishing Group Ltd., 2015)
      Objectives: To quantify risk of overall cancer across all levels of alcohol consumption among women and men separately, with a focus on light to moderate drinking and never smokers; and assess the influence of drinking ...
    • Mannose-Binding Lectin 2 Gene and Risk of Adult Glioma 

      Michaud, Dominique S.; Siddiq, Afshan; Cox, David G.; Backes, Danielle M.; Calboli, Federico C. F.; Sughrue, Michael E.; Gaziano, John Michael; Ma, Jing; Stampfer, Meir Jonathan; Tworoger, Shelley Slate; Hunter, David J.; Camargo, Carlos Arturo; Parsa, Andrew T. (Public Library of Science, 2013)
      Background and Aims The immune system is likely to play a key role in the etiology of gliomas. Genetic polymorphisms in the mannose-binding lectin gene, a key activator in the lectin complement pathway, have been associated ...
    • A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer 

      Al Olama, Ali Amin; Kote-Jarai, Zsofia; Berndt, Sonja I.; Conti, David V.; Schumacher, Fredrick; Han, Ying; Benlloch, Sara; Hazelett, Dennis J.; Wang, Zhaoming; Saunders, Ed; Leongamornlert, Daniel; Lindstrom, Sara; Jugurnauth-Little, Sara; Dadaev, Tokhir; Tymrakiewicz, Malgorzata; Stram, Daniel O.; Rand, Kristin; Wan, Peggy; Stram, Alex; Sheng, Xin; Pooler, Loreall C.; Park, Karen; Xia, Lucy; Tyrer, Jonathan; Kolonel, Laurence N.; Le Marchand, Loic; Hoover, Robert N.; Machiela, Mitchell J.; Yeager, Merideth; Burdette, Laurie; Chung, Charles C.; Hutchinson, Amy; Yu, Kai; Goh, Chee; Ahmed, Mahbubl; Govindasami, Koveela; Guy, Michelle; Tammela, Teuvo L.J.; Auvinen, Anssi; Wahlfors, Tiina; Schleutker, Johanna; Visakorpi, Tapio; Leinonen, Katri A.; Xu, Jianfeng; Aly, Markus; Donovan, Jenny; Travis, Ruth C.; Key, Tim J.; Siddiq, Afshan; Canzian, Federico; Khaw, Kay-Tee; Takahashi, Atsushi; Kubo, Michiaki; Pharoah, Paul; Pashayan, Nora; Weischer, Maren; Nordestgaard, Borge G.; Nielsen, Sune F.; Klarskov, Peter; Røder, Martin Andreas; Iversen, Peter; Thibodeau, Stephen N.; McDonnell, Shannon K; Schaid, Daniel J; Stanford, Janet L.; Kolb, Suzanne; Holt, Sarah; Knudsen, Beatrice; Coll, Antonio Hurtado; Gapstur, Susan M.; Diver, W. Ryan; Stevens, Victoria L.; Maier, Christiane; Luedeke, Manuel; Herkommer, Kathleen; Rinckleb, Antje E.; Strom, Sara S.; Pettaway, Curtis; Yeboah, Edward D.; Tettey, Yao; Biritwum, Richard B.; Adjei, Andrew A.; Tay, Evelyn; Truelove, Ann; Niwa, Shelley; Chokkalingam, Anand P.; Cannon-Albright, Lisa; Cybulski, Cezary; Wokołorczyk, Dominika; Kluźniak, Wojciech; Park, Jong; Sellers, Thomas; Lin, Hui-Yi; Isaacs, William B.; Partin, Alan W.; Brenner, Hermann; Dieffenbach, Aida Karina; Stegmaier, Christa; Chen, Constance; Giovannucci, Edward L.; Ma, Jing; Stampfer, Meir; Penney, Kathryn L.; Mucci, Lorelei; John, Esther M.; Ingles, Sue A.; Kittles, Rick A.; Murphy, Adam B.; Pandha, Hardev; Michael, Agnieszka; Kierzek, Andrzej M.; Blot, William; Signorello, Lisa B.; Zheng, Wei; Albanes, Demetrius; Virtamo, Jarmo; Weinstein, Stephanie; Nemesure, Barbara; Carpten, John; Leske, Cristina; Wu, Suh-Yuh; Hennis, Anselm; Kibel, Adam S.; Rybicki, Benjamin A.; Neslund-Dudas, Christine; Hsing, Ann W.; Chu, Lisa; Goodman, Phyllis J.; Klein, Eric A; Zheng, S. Lilly; Batra, Jyotsna; Clements, Judith; Spurdle, Amanda; Teixeira, Manuel R.; Paulo, Paula; Maia, Sofia; Slavov, Chavdar; Kaneva, Radka; Mitev, Vanio; Witte, John S.; Casey, Graham; Gillanders, Elizabeth M.; Seminara, Daniella; Riboli, Elio; Hamdy, Freddie C.; Coetzee, Gerhard A.; Li, Qiyuan; Freedman, Matthew L.; Hunter, David J.; Muir, Kenneth; Gronberg, Henrik; Neal, David E.; Southey, Melissa; Giles, Graham G.; Severi, Gianluca; Cook, Michael B.; Nakagawa, Hidewaki; Wiklund, Fredrik; Kraft, Peter; Chanock, Stephen J.; Henderson, Brian E.; Easton, Douglas F.; Eeles, Rosalind A.; Haiman, Christopher A. (2014)
      Genome-wide association studies (GWAS) have identified 76 variants associated with prostate cancer risk predominantly in populations of European ancestry. To identify additional susceptibility loci for this common cancer, ...
    • Molecular Sampling of Prostate Cancer: A Dilemma for Predicting Disease Progression 

      Sboner, Andrea; Demichelis, Francesca; Calza, Stefano; Pawitan, Yudi; Hoshida, Yujin; Perner, Sven; Andersson, Swen-Olof; Varenhorst, Eberhard; Johansson, Jan-Erik; Gerstein, Mark B; Rubin, Mark A; Andrén, Ove; Setlur, Sunita Ramakrishna; Adami, Hans-Olov; Fall, Katja; Mucci, Lorelei Ann; Kantoff, Philip Wayne; Stampfer, Meir Jonathan; Golub, Todd R. (BioMed Central, 2010)
      Background: Current prostate cancer prognostic models are based on pre-treatment prostate specific antigen (PSA) levels, biopsy Gleason score, and clinical staging but in practice are inadequate to accurately predict disease ...
    • Muscle-Strengthening and Conditioning Activities and Risk of Type 2 Diabetes: A Prospective Study in Two Cohorts of US Women 

      Grøntved, Anders; Pan, An; Mekary, Rania A.; Stampfer, Meir; Willett, Walter C.; Manson, JoAnn E.; Hu, Frank B. (Public Library of Science, 2014)
      Background: It is well established that aerobic physical activity can lower the risk of type 2 diabetes (T2D), but whether muscle-strengthening activities are beneficial for the prevention of T2D is unclear. This study ...
    • Nut consumption and risk of colorectal cancer in women 

      Yang, Meng; Hu, Frank B.; Giovannucci, Edward L.; Stampfer, Meir Jonathan; Willett, Walter C.; Fuchs, Charles Stewart; Wu, Kana; Bao, Ying (Nature Publishing Group, 2015)
      Background/Objectives: Increasing nut consumption has been associated with reduced risk of obesity and type II diabetes, which are risk factors for colorectal cancer. However, the association between nut consumption and ...
    • Nutritional and Lifestyle Factors for Cancer Incidence and Survival 

      Zoltick, Emilie Sela (2016-09-28)
      Background: The association between meat consumption and breast cancer risk and the relationship between vitamin D and colorectal cancer risk have been examined in numerous studies, but questions still remain. For colorectal ...