Now showing items 1-13 of 13

    • Adiponectin Gene Polymorphisms and Acute Respiratory Distress Syndrome Susceptibility and Mortality 

      Ahasic, Amy M.; Zhao, Yang; Su, Li; Sheu, Chau-Chyun; Thompson, B. Taylor; Christiani, David C. (Public Library of Science, 2014)
      Rationale: Adiponectin is an anti-inflammatory adipokine that is the most abundant gene product of adipose tissue. Lower levels have been observed in obesity, insulin resistance, and in critical illness. However, elevated ...
    • Chronic Lung Function Decline in Cotton Textile Workers: Roles of Historical and Recent Exposures to Endotoxin 

      Shi, Ping; Mehta, Amar J.; Hang, Jing-qing; Zhang, Hongxi; Dai, Helian; Su, Li; Eisen, Ellen A.; Christiani, David C. (National Institute of Environmental Health Sciences, 2010)
      Background: Long-term occupational exposure to cotton dust that contains endotoxin is associated with chronic respiratory symptoms and excessive decline in forced expiratory volume in 1 sec (FEV1), but the mechanisms of ...
    • Global Gene Expression Profiling in Whole-Blood Samples From Individuals Exposed to Metal Fumes 

      Wang, Zhaoxi; Neuburg, Donna; Li, Cheng; Su, Li; Kim, Jee Young; Chen, Jiu Chiuan; Christiani, David C. (National Institute of Environmental Health Sciences, 2005)
      Accumulating evidence demonstrates that particulate air pollutants can cause both pulmonary and airway inflammation. However, few data show that particulates can induce systemic inflammatory responses. We conducted an ...
    • Global Metabolomic Profiling Reveals an Association of Metal Fume Exposure and Plasma Unsaturated Fatty Acids 

      Wei, Yongyue; Wang, Zhaoxi; Chang, Chiung-yu; Fan, Tianteng; Su, Li; Chen, Feng; Christiani, David C. (Public Library of Science, 2013)
      Background: Welding-associated air pollutants negatively affect the health of exposed workers; however, their molecular mechanisms in causing disease remain largely unclear. Few studies have systematically investigated the ...
    • Heart rate variability and DNA methylation levels are altered after short-term metal fume exposure among occupational welders: a repeated-measures panel study 

      Fan, Tianteng; Fang, Shona C; Cavallari, Jennifer M; Barnett, Ian J; Wang, Zhaoxi; Su, Li; Byun, Hyang-Min; Lin, Xihong; Baccarelli, Andrea A; Christiani, David C (BioMed Central, 2014)
      Background: In occupational settings, boilermakers are exposed to high levels of metallic fine particulate matter (PM2.5) generated during the welding process. The effect of welding PM2.5 on heart rate variability (HRV) ...
    • Imaging Phenotype of Occupational Endotoxin-Related Lung Function Decline 

      Lai, Peggy S.; Hang, Jing-qing; Zhang, Feng-ying; Sun, J.; Zheng, Bu-Yong; Su, Li; Washko, George R.; Christiani, David C. (National Institute of Environmental Health Sciences, 2016)
      Background: Although occupational exposures contribute to a significant proportion of obstructive lung disease, the phenotype of obstructive lung disease associated with work-related organic dust exposure independent of ...
    • In-Home Solid Fuel Use and Cardiovascular Disease: A Cross-Sectional Analysis of the Shanghai Putuo Study 

      Lee, Mi-Sun; Hang, Jing-qing; Zhang, Feng-ying; Dai, He-lian; Su, Li; Christiani, David C. (BioMed Central, 2012)
      Background: Although recent research evidence suggests an association between household air pollution from solid fuel use, such as coal or biomass, and cardiovascular events such as hypertension, little epidemiologic data ...
    • A Large Scale Gene-Centric Association Study of Lung Function in Newly-Hired Female Cotton Textile Workers with Endotoxin Exposure 

      Zhang, Ruyang; Zhao, Yang; Chu, Minjie; Mehta, Amar Jayant; Wei, Yongyue; Liu, Yao; Xun, Pengcheng; Bai, Jianling; Yu, Hao; Su, Li; Zhang, Hongxi; Hu, Zhibin; Shen, Hongbing; Chen, Feng; Christiani, David C. (Public Library of Science, 2013)
      Background: Occupational exposure to endotoxin is associated with decrements in pulmonary function, but how much variation in this association is explained by genetic variants is not well understood. Objective: We aimed ...
    • Lung Adenocarcinoma with EGFR Amplification Has Distinct Clinicopathologic and Molecular Features in Never-Smokers 

      Sholl, Lynette Marie; Yeap, Beow Yong; Iafrate, Anthony John; Holmes-Tisch, A. J.; Chou, Y.-P.; Wu, Ming-Tsang; Goan, Y.-G.; Su, Li; Benedettini, E.; Yu, J.; Loda, Massimo; Janne, Pasi Antero; Christiani, David Christopher; Chirieac, Lucian Radu (American Association for Cancer Research (AACR), 2009)
      In a subset of lung adenocarcinomas the epidermal growth factor receptor (EGFR) is activated by kinase domain mutations and/or gene amplification, but the interaction between the two types of abnormalities is complex and ...
    • A Novel Genetic Variant in Long Non-coding RNA Gene NEXN-AS1 is Associated with Risk of Lung Cancer 

      Yuan, Hua; Liu, Hongliang; Liu, Zhensheng; Owzar, Kouros; Han, Younghun; Su, Li; Wei, Yongyue; Hung, Rayjean J.; McLaughlin, John; Brhane, Yonathan; Brennan, Paul; Bickeboeller, Heike; Rosenberger, Albert; Houlston, Richard S.; Caporaso, Neil; Landi, Maria Teresa; Heinrich, Joachim; Risch, Angela; Christiani, David C.; Gümüş, Zeynep H.; Klein, Robert J.; Amos, Christopher I.; Wei, Qingyi (Nature Publishing Group, 2016)
      Lung cancer etiology is multifactorial, and growing evidence has indicated that long non-coding RNAs (lncRNAs) are important players in lung carcinogenesis. We performed a large-scale meta-analysis of 690,564 SNPs in 15,531 ...
    • Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer 

      Wang, Yufei; McKay, James D; Rafnar, Thorunn; Wang, Zhaoming; Timofeeva, Maria N; Broderick, Peter; Zong, Xuchen; Laplana, Marina; Wei, Yongyue; Han, Younghun; Lloyd, Amy; Delahaye-Sourdeix, Manon; Chubb, Daniel; Gaborieau, Valerie; Wheeler, William; Chatterjee, Nilanjan; Thorleifsson, Gudmar; Sulem, Patrick; Liu, Geoffrey; Kaaks, Rudolf; Henrion, Marc; Kinnersley, Ben; Vallée, Maxime; LeCalvez-Kelm, Florence; Stevens, Victoria L; Gapstur, Susan M; Chen, Wei V; Zaridze, David; Szeszenia-Dabrowska, Neonilia; Lissowska, Jolanta; Rudnai, Peter; Fabianova, Eleonora; Mates, Dana; Bencko, Vladimir; Foretova, Lenka; Janout, Vladimir; Krokan, Hans E; Gabrielsen, Maiken Elvestad; Skorpen, Frank; Vatten, Lars Johan; Njølstad, Inger; Chen, Chu; Goodman, Gary; Benhamou, Simone; Vooder, Tonu; Välk, Kristjan; Nelis, Mari; Metspalu, Andres; Lener, Marcin; Lubiński, Jan; Johansson, Mattias; Vineis, Paolo; Agudo, Antonio; Clavel-Chapelon, Francoise; Bueno-de-Mesquita, H Bas; Trichopoulos, Dimitrios; Khaw, Kay-Tee; Johansson, Mikael; Weiderpass, Elisabete; Tjønneland, Anne; Riboli, Elio; Lathrop, Mark; Scelo, Ghislaine; Albanes, Demetrius; Caporaso, Neil E; Ye, Yuanqing; Gu, Jian; Wu, Xifeng; Spitz, Margaret R; Dienemann, Hendrik; Rosenberger, Albert; Su, Li; Matakidou, Athena; Eisen, Timothy; Stefansson, Kari; Risch, Angela; Chanock, Stephen J; Christiani, David Christopher; Hung, Rayjean J; Brennan, Paul; Landi, Maria Teresa; Houlston, Richard S; Amos, Christopher I (Springer Nature, 2014)
      We conducted imputation to the 1000 Genomes Project of four genome-wide association studies of lung cancer in populations of European ancestry (11,348 cases and 15,861 controls) and genotyped an additional 10,246 cases and ...
    • A single-nucleotide polymorphism in the methylene tetrahydrofolate reductase (MTHFR) gene is associated with risk of radiation pneumonitis in lung cancer patients treated with thoracic radiation therapy 

      Mak, Raymond Heungwing; Alexander, Brian Michael; Asomaning, Kofi; Heist, Rebecca Suk; Liu, Chen-yu; Su, Li; Zhai, Rihong; Ancukiewicz, Marek; Napolitano, Brian; Niemierko, Andrzej; Willers, Henning; Choi, Noah Chan H; Christiani, David Christopher (Wiley-Blackwell, 2011)
      Background: To study the association between functional single nucleotide polymorphisms (SNPs) in candidate genes from oxidative stress pathways, and risk of radiation pneumonitis (RP) in patients treated with thoracic ...
    • Socioeconomic status is associated with reduced lung function in China: an analysis from a large cross-sectional study in Shanghai 

      Gaffney, Adam W.; Hang, Jing-qing; Lee, Mi-Sun; Su, Li; Zhang, Feng-ying; Christiani, David C. (BioMed Central, 2016)
      Background: An inverse association between socioeconomic status and pulmonary function has emerged in many studies. However, the mediating factors in this relationship are poorly understood, and might be expected to differ ...