Browsing by Author "Comstock, Laurie"
Now showing items 1-6 of 6
-
Bacteroidales Secreted Antimicrobial Proteins Target Surface Molecules Necessary for Gut Colonization and Mediate Competition In Vivo
Roelofs, Kevin G.; Coyne, Michael J.; Gentyala, Rahul R.; Chatzidaki-Livanis, Maria; Comstock, Laurie E. (American Society for Microbiology, 2016)ABSTRACT We recently showed that human gut Bacteroidales species secrete antimicrobial proteins (BSAPs), and we characterized in vitro the first such BSAP produced by Bacteroides fragilis. In this study, we identified a ... -
Characterization of Adherent Bacteroidales from Intestinal Biopsies of Children and Young Adults with Inflammatory Bowel Disease
Zitomersky, Naamah L.; Atkinson, Benjamin J.; Franklin, Sarah W.; Mitchell, Paul D.; Snapper, Scott B.; Comstock, Laurie E.; Bousvaros, Athos (Public Library of Science, 2013)There is extensive evidence implicating the intestinal microbiota in inflammatory bowel disease [IBD], but no microbial agent has been identified as a sole causative agent. Bacteroidales are numerically dominant intestinal ... -
Evidence of Extensive DNA Transfer between Bacteroidales Species within the Human Gut
Coyne, Michael J.; Zitomersky, Naamah Levy; McGuire, Abigail Manson; Earl, Ashlee M.; Comstock, Laurie E. (American Society of Microbiology, 2014)ABSTRACT The genome sequences of intestinal Bacteroidales strains reveal evidence of extensive horizontal gene transfer. In vitro studies of Bacteroides and other bacteria have addressed mechanisms of conjugative transfer ... -
The evolution of cooperation within the gut microbiota
Rakoff-Nahoum, Seth; Foster, Kevin R.; Comstock, Laurie E. (2016)Cooperative phenotypes are considered central to the functioning of microbial communities in many contexts, including communication via quorum sensing, biofilm formation, antibiotic resistance, and pathogenesis1-5. The ... -
Production of α-Galactosylceramide by a Prominent Member of the Human Gut Microbiota
Wieland Brown, Laura C.; Penaranda, Cristina; Kashyap, Purna C.; Williams, Brianna B.; Clardy, Jon; Kronenberg, Mitchell; Sonnenburg, Justin L.; Comstock, Laurie E.; Bluestone, Jeffrey A.; Fischbach, Michael A. (Public Library of Science, 2013)While the human gut microbiota are suspected to produce diffusible small molecules that modulate host signaling pathways, few of these molecules have been identified. Species of Bacteroides and their relatives, which often ... -
Type VI secretion systems of human gut Bacteroidales segregate into three genetic architectures, two of which are contained on mobile genetic elements
Coyne, Michael J.; Roelofs, Kevin G.; Comstock, Laurie E. (BioMed Central, 2016)Background: Type VI secretion systems (T6SSs) are contact-dependent antagonistic systems employed by Gram negative bacteria to intoxicate other bacteria or eukaryotic cells. T6SSs were recently discovered in a few Bacteroidetes ...