Now showing items 1-12 of 12

    • Biocompatibility and biofilm inhibition of N,N-hexyl,methyl-polyethylenimine bonded to Boston Keratoprosthesis materials 

      Behlau, Irmgard; Mukherjee, Koushik; Todani, Amit; Tisdale, Ann S.; Cade, Fabiano; Wang, Liqiang; Leonard, Elizabeth M.; Zakka, Fouad R.; Gilmore, Michael S.; Jakobiec, Frederick A.; Dohlman, Claes Henrik; Klibanov, Alexander M. (Elsevier BV, 2011)
      The biocompatibility and antibacterial properties of N,N-hexyl,methyl-polyethylenimine (HMPEI) covalently attached to the Boston Keratoprosthesis (B-KPro) materials was evaluated. By means of confocal and electron microscopies, ...
    • Corneal Inflammation After Miniature Keratoprosthesis Implantation 

      Crnej, A.; Omoto, M.; Dohlman, T. H.; Dohlman, Claes Henrik; Dana, Reza (Association for Research in Vision and Ophthalmology (ARVO), 2014)
      Purpose.: To compare corneal inflammation after syngeneic and allogeneic penetrating keratoplasty (PK) with miniature Keratoprosthesis (m-KPro) implantation in mice. Methods.: BALB/C (syngeneic) or C57BL/6 (allogeneic) ...
    • A Drug Delivery System for Administration of Anti–TNF-α Antibody 

      Robert, Marie-Claude; Frenette, Mathieu; Zhou, Chengxin; Yan, Yueran; Chodosh, James; Jakobiec, Frederick A.; Stagner, Anna M.; Vavvas, Demetrios; Dohlman, Claes H.; Paschalis, Eleftherios I. (The Association for Research in Vision and Ophthalmology, 2016)
      Purpose To describe the fabrication, evaluation, and preliminary in vivo safety of a new drug delivery system (DDS) for topical anti–TNF-α antibody administration. Methods: A DDS was fabricated using inverse template ...
    • Effect of Penetrating Keratoplasty and Keratoprosthesis Implantation on the Posterior Segment of the Eye 

      Črnej, Alja; Omoto, Masahiro; Dohlman, Thomas H.; Gonzalez-Andrades, Miguel; Paschalis, Eleftherios I.; Cruzat, Andrea; Vu, T. H. Khanh; Doorenbos, Marianne; Chen, Dong Feng; Dohlman, Claes H.; Dana, Reza (The Association for Research in Vision and Ophthalmology, 2016)
      Purpose To compare the effects of post-penetrating keratoplasty (PK) and post-keratoprosthesis (KPro) surgery-related inflammation on the posterior segment of the eye and to assess inhibition of tumor necrosis factor alpha ...
    • Establishment of a novel in vitro model of stratified epithelial wound healing with barrier function 

      Gonzalez-Andrades, Miguel; Alonso-Pastor, Luis; Mauris, Jérôme; Cruzat, Andrea; Dohlman, Claes H.; Argüeso, Pablo (Nature Publishing Group, 2016)
      The repair of wounds through collective movement of epithelial cells is a fundamental process in multicellular organisms. In stratified epithelia such as the cornea and skin, healing occurs in three steps that include a ...
    • Low-Cost and Readily Available Tissue Carriers for the Boston Keratoprosthesis: A Review of Possibilities 

      Cruzat, Andrea; Tauber, Allyson; Shukla, Anita; Paschalis, Eleftherios I.; Pineda, Roberto; Dohlman, Claes H. (Hindawi Publishing Corporation, 2013)
      The Boston keratoprosthesis (B-KPro), currently the most commonly used artificial cornea worldwide, can provide rapid visual rehabilitation for eyes with severe corneal opacities not suitable for standard corneal ...
    • A Novel Implantable Glaucoma Valve Using Ferrofluid 

      Paschalis, Eleftherios I.; Chodosh, James; Sperling, Ralph A.; Salvador-Culla, Borja; Dohlman, Claes (Public Library of Science, 2013)
      Purpose To present a novel design of an implantable glaucoma valve based on ferrofluidic nanoparticles and to compare it with a well-established FDA approved valve. Setting: Massachusetts Eye & Ear Infirmary, Boston, USA. ...
    • A Novel Murine Model for Keratoprosthesis 

      Crnej, Alja; Omoto, Masahiro; Dohlman, Thomas H.; Graney, John M.; Dohlman, Claes Henrik; Drnovsek-Olup, Brigita; Dana, Reza (Association for Research in Vision and Ophthalmology (ARVO), 2014)
      Purpose. To establish a murine model for keratoprosthesis. Methods. A miniature keratoprosthesis (m-KPro) device was created consisting of a poly[methyl methacrylate] front part and a titanium back plate, designed ...
    • Oral Acetazolamide after Boston Keratoprosthesis in Stevens Johnson Syndrome 

      Kumar, Radhika; Dohlman, Claes Henrik; Chodosh, James (BioMed Central, 2012)
      Background: Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is a rare but severe and sometimes fatal condition associated with exposure to medications; sulfamethoxazole is among the most common causes. We ...
    • Reliable intraocular pressure measurement using automated radio-wave telemetry 

      Paschalis, Eleftherios I; Cade, Fabiano; Melki, Samir; Pasquale, Louis R; Dohlman, Claes H; Ciolino, Joseph B (Dove Medical Press, 2014)
      Purpose To present an autonomous intraocular pressure (IOP) measurement technique using a wireless implantable transducer (WIT) and a motion sensor. Methods: The WIT optical aid was implanted within the ciliary sulcus of ...
    • Sustained Subconjunctival Delivery of Infliximab Protects the Cornea and Retina Following Alkali Burn to the Eye 

      Zhou, Chengxin; Robert, Marie-Claude; Kapoulea, Vassiliki; Lei, Fengyang; Stagner, Anna M.; Jakobiec, Frederick A.; Dohlman, Claes H.; Paschalis, Eleftherios I. (The Association for Research in Vision and Ophthalmology, 2017)
      Purpose Tumor necrosis factor (TNF)-α is upregulated in eyes following corneal alkali injury and contributes to corneal and also retinal damage. Prompt TNF-α inhibition by systemic infliximab ameliorates retinal damage and ...
    • Titanium Coating of the Boston Keratoprosthesis 

      Salvador-Culla, Borja; Jeong, Kyung Jae; Kolovou, Paraskevi Evi; Chiang, Homer H.; Chodosh, James; Dohlman, Claes H.; Kohane, Daniel S. (The Association for Research in Vision and Ophthalmology, 2016)
      Purpose We tested the feasibility of using titanium to enhance adhesion of the Boston Keratoprosthesis (B-KPro), ultimately to decrease the risk of implant-associated complications. Methods: Cylindrical rods were made of ...