Now showing items 1-8 of 8

    • Assessing the Performance of a Computer-Based Policy Model of HIV and AIDS 

      Rydzak, Chara Elaine; Cotich, Kara L.; Sax, Paul Edward; Hsu, Heather Emery Smith; Wang, Bingxia; Losina, Elena; Freedberg, Kenneth Alan; Weinstein, Milton C.; Goldie, Sue J. (2010)
      Background: Model-based analyses, conducted within a decision analytic framework, provide a systematic way to combine information about the natural history of disease and effectiveness of clinical management strategies ...
    • Cost-Effectiveness of Genotype Testing for Primary Resistance in Brazil 

      Luz, Paula M.; Morris, Bethany L.; Grinsztejn, Beatriz; Freedberg, Kenneth A.; Veloso, Valdilea G.; Walensky, Rochelle P.; Losina, Elena; Nakamura, Yoriko M.; Girouard, Michael P.; Sax, Paul E.; Struchiner, Claudio J.; Paltiel, A. David (JAIDS Journal of Acquired Immune Deficiency Syndromes, 2014)
      Objective: HIV genotype-resistance testing can help identify more effective antiretroviral treatment (ART) regimens for patients, substantially increasing the likelihood of viral suppression and immune recovery. We sought ...
    • Cystatin C-Based Renal Function Changes After Antiretroviral Initiation: A Substudy of a Randomized Trial 

      Gupta, Samir K.; Kitch, Douglas; Tierney, Camlin; Daar, Eric S.; Sax, Paul E.; Melbourne, Kathleen; Ha, Belinda; McComsey, Grace A. (Oxford University Press, 2014)
      Background. The effects of antiretrovirals on cystatin C-based renal function estimates are unknown. Methods. We analyzed changes in renal function using creatinine and cystatin C-based estimating equations in 269 patients ...
    • HIV Cure Strategies: How Good Must They Be to Improve on Current Antiretroviral Therapy? 

      Sax, Paul E.; Sypek, Alexis; Berkowitz, Bethany K.; Morris, Bethany L.; Losina, Elena; Paltiel, A. David; Kelly, Kathleen A.; Seage, George R.; Walensky, Rochelle P.; Weinstein, Milton C.; Eron, Joseph; Freedberg, Kenneth A. (Public Library of Science, 2014)
      Background: We examined efficacy, toxicity, relapse, cost, and quality-of-life thresholds of hypothetical HIV cure interventions that would make them cost-effective compared to life-long antiretroviral therapy (ART). ...
    • Lower Pill Burden and Once-Daily Antiretroviral Treatment Regimens for HIV Infection: A Meta-Analysis of Randomized Controlled Trials 

      Nachega, Jean B.; Parienti, Jean-Jacques; Uthman, Olalekan A.; Gross, Robert; Dowdy, David W.; Sax, Paul E.; Gallant, Joel E.; Mugavero, Michael J.; Mills, Edward J.; Giordano, Thomas P. (Oxford University Press, 2014)
      Background. Contemporary antiretroviral treatment regimens are simpler than in the past, with lower pill burden and once-daily dosing frequency common. We performed a meta-analysis of randomized controlled trials (RCTs) ...
    • On the Nose 

      Abdalla, Marwah; Sax, Paul Edward; Mostaghimi, Arash; Miller, Amy Leigh; Loscalzo, Joseph (New England Journal of Medicine (NEJM/MMS), 2015)
      A 67-year-old man presented with a 3-day history of chest tightness, wheezing, coughing, and dyspnea. He had a history of asthma but had not had major exacerbations for 20 years. He did not have fever, sputum production, ...
    • Safety and immunogenicity of therapeutic DNA vaccination in individuals treated with antiretroviral therapy during acute/early HIV-1 infection 

      Graham, Barney S.; Stocker, Vicki; Maenza, Janine; Markowitz, Martin; Little, Susan; Collier, Ann C.; Nabel, Gary; Saindon, Suzanne; Flynn, Theresa; Ostrowski, Mario A.; Rosenberg, Eric Scott; Chan, Ellen S.L.; Bosch, Ronald J.; Sax, Paul Edward; Kuritzkes, Daniel Robert; Barouch, Dan Hung (Public Library of Science, 2010)
      Background: An effective therapeutic vaccine that could augment immune control of HIV-1 replication may abrogate or delay the need for antiretroviral therapy. AIDS Clinical Trials Group (ACTG) A5187 was a phase I/II, ...
    • Short and Long-Term Effects of Telaprevir on Kidney Function in Patients with Hepatitis C Virus Infection: A Retrospective Cohort Study 

      Sise, Meghan E.; Backman, Elke S.; Wenger, Julia B.; Wood, Brian R.; Sax, Paul E.; Chung, Raymond T.; Thadhani, Ravi; Kim, Arthur Y. (Public Library of Science, 2015)
      Background: Recent reports suggest that telaprevir, a protease inhibitor used to treat hepatitis C infection, is associated with decline in kidney function during therapy, particularly in patients with baseline renal ...