Browsing by Author "Howley, Peter"
Now showing items 1-6 of 6
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Components of the Ubiquitin-Proteasome Pathway Compete for Surfaces on Rad23 Family Proteins
Goh, Amanda M; Walters, Kylie J; Elsasser, Suzanne; Verma, Rati; Deshaies, Raymond J; Finley, Daniel J.; Howley, Peter M. (BioMed Central, 2008)Background: The delivery of ubiquitinated proteins to the proteasome for degradation is a key step in the regulation of the ubiquitin-proteasome pathway, yet the mechanisms underlying this step are not understood in detail. ... -
High-Risk Human Papillomavirus E7 Proteins Target PTPN14 for Degradation
White, Elizabeth A.; Münger, Karl; Howley, Peter M. (American Society for Microbiology, 2016)ABSTRACT The major transformation activity of the high-risk human papillomaviruses (HPV) is associated with the E7 oncoprotein. The interaction of HPV E7 with retinoblastoma family proteins is important for several E7 ... -
Human Papillomavirus E6 Triggers Upregulation of the Antiviral and Cancer Genomic DNA Deaminase APOBEC3B
Vieira, Valdimara C.; Leonard, Brandon; White, Elizabeth A.; Starrett, Gabriel J.; Temiz, Nuri A.; Lorenz, Laurel D.; Lee, Denis; Soares, Marcelo A.; Lambert, Paul F.; Howley, Peter M.; Harris, Reuben S. (American Society of Microbiology, 2014)ABSTRACT Several recent studies have converged upon the innate immune DNA cytosine deaminase APOBEC3B (A3B) as a significant source of genomic uracil lesions and mutagenesis in multiple human cancers, including those of ... -
Identification of the Cellular Proteins and Pathways Engaged by the Bovine Papillomavirus Type 1 E6 and E7 Proteins
Tan, Min Jie Alvin (2013-10-15)Bovine papillomavirus type 1 (BPV1) induces fibropapillomas in cattle, and has long served as a useful model virus to study the molecular biology of the papillomaviruses. The cellular transforming activity of BPV1 maps to ... -
Molecular Insight into Function of the Evolutionarily Conserved Brd4 Extraterminal Domain (ET) and Mechanism of Brd4 Functions in Human Diseases
Rahman, Shaila (2013-02-11)Bromodomain protein 4 (Brd4) plays critical roles in development, cancer progression and virus-host pathogenesis. Papillomaviruses (PV) E2 protein associates with Brd4 and this interaction is important for transcriptional ... -
Proteomic Analysis and Identification of Cellular Interactors of the Giant Ubiquitin Ligase HERC2
Galligan, Jeffrey T.; Martinez-Noël, Gustavo; Arndt, Verena; Hayes, Sebastian; Chittenden, Thomas W.; Harper, J. Wade; Howley, Peter M. (American Chemical Society, 2014)HERC2 is a large E3 ubiquitin ligase with multiple structural domains that has been implicated in an array of cellular processes. Mutations in HERC2 are linked to developmental delays and impairment caused by nervous system ...