Now showing items 1-11 of 11

    • Association of Novel Biomarkers of Cardiovascular Stress With Left Ventricular Hypertrophy and Dysfunction: Implications for Screening 

      Xanthakis, Vanessa; Larson, Martin G.; Wollert, Kai C.; Aragam, Jayashri; Cheng, Susan; Ho, Jennifer; Coglianese, Erin; Levy, Daniel; Colucci, Wilson S.; Michael Felker, G.; Benjamin, Emelia J.; Januzzi, James L.; Wang, Thomas J.; Vasan, Ramachandran S. (Blackwell Publishing Ltd, 2013)
      Background: Currently available screening tools for left ventricular (LV) hypertrophy (LVH) and systolic dysfunction (LVSD) are either expensive (echocardiography) or perform suboptimally (B‐type natriuretic peptide [BNP]). ...
    • Common Genetic Variation at the IL1RL1 Locus Regulates IL-33/ST2 Signaling 

      Ho, Jennifer E.; Chen, Wei-Yu; Chen, Ming-Huei; Larson, Martin G.; McCabe, Elizabeth L.; Cheng, Susan; Ghorbani, Anahita; Coglianese, Erin; Emilsson, Valur; Johnson, Andrew D.; Walter, Stefan; Franceschini, Nora; O'Donnell, Christopher Joseph; Dehghan, Abbas; Lu, Chen; Levy, Daniel; Newton-Cheh, Christopher Holmes; Lin, Honghuang; Felix, Janine F.; Schreiter, Eric R.; Vasan, Ramachandran S.; Januzzi, James Louis; Lee, Richard Theodore; Wang, Thomas (American Society for Clinical Investigation, 2013)
      The suppression of tumorigenicity 2/IL-33 (ST2/IL-33) pathway has been implicated in several immune and inflammatory diseases. ST2 is produced as 2 isoforms. The membrane-bound isoform (ST2L) induces an immune response ...
    • Distinct Metabolomic Signatures Are Associated with Longevity in Humans 

      Cheng, Susan; Larson, Martin G.; McCabe, Elizabeth L.; Murabito, Joanne M.; Rhee, Eugene P.; Ho, Jennifer E.; Jacques, Paul F.; Ghorbani, Anahita; Magnusson, Martin; Souza, Amanda L.; Deik, Amy A.; Pierce, Kerry A.; Bullock, Kevin; O’Donnell, Christopher J.; Melander, Olle; Clish, Clary B.; Vasan, Ramachandran S.; Gerszten, Robert E.; Wang, Thomas J. (2015)
      Alterations in metabolism influence lifespan in experimental models, but data in humans are lacking. Here we use liquid chromatography/mass spectrometry to quantify 217 plasma metabolites and examine their relation to ...
    • Genetic Loci Associated With Atrial Fibrillation: Relation to Left Atrial Structure in the Framingham Heart Study 

      Magnani, Jared W.; Yin, Xiaoyan; McManus, David D.; Chuang, Michael L.; Cheng, Susan; Lubitz, Steven A.; Arora, Garima; Manning, Warren J.; Ellinor, Patrick T.; Benjamin, Emelia J. (Blackwell Publishing Ltd, 2014)
      Background: Atrial fibrillation (AF) results in significant morbidity and mortality. Genome‐wide association studies (GWAS) have identified genetic variants associated with AF. Whether genetic variants associated with AF ...
    • Identifying Early Changes in Myocardial Microstructure in Hypertensive Heart Disease 

      Hiremath, Pranoti; Bauer, Michael; Aguirre, Aaron D.; Cheng, Hui-Wen; Unno, Kazumasa; Patel, Ravi B.; Harvey, Bethany W.; Chang, Wei-Ting; Groarke, John D.; Liao, Ronglih; Cheng, Susan (Public Library of Science, 2014)
      The transition from healthy myocardium to hypertensive heart disease is characterized by a series of poorly understood changes in myocardial tissue microstructure. Incremental alterations in the orientation and integrity ...
    • Long‐term Cardiovascular Risks Associated With an Elevated Heart Rate: The Framingham Heart Study 

      Ho, Jennifer E.; Larson, Martin G.; Ghorbani, Anahita; Cheng, Susan; Coglianese, Erin E.; Vasan, Ramachandran S.; Wang, Thomas J. (Blackwell Publishing Ltd, 2014)
      Background: Higher heart rate has been associated with an adverse prognosis, but most prior studies focused on individuals with known cardiovascular disease or examined a limited number of outcomes. We sought to examine ...
    • Metabolite Profiles During Oral Glucose Challenge 

      Ho, Jennifer E.; Larson, Martin G.; Vasan, Ramachandran S.; Ghorbani, Anahita; Cheng, Susan; Rhee, Eugene P.; Florez, Jose C.; Clish, Clary B.; Gerszten, Robert E.; Wang, Thomas J. (American Diabetes Association, 2013)
      To identify distinct biological pathways of glucose metabolism, we conducted a systematic evaluation of biochemical changes after an oral glucose tolerance test (OGTT) in a community-based population. Metabolic profiling ...
    • Metabolomic Profiles of Body Mass Index in the Framingham Heart Study Reveal Distinct Cardiometabolic Phenotypes 

      Ho, Jennifer E.; Larson, Martin G.; Ghorbani, Anahita; Cheng, Susan; Chen, Ming-Huei; Keyes, Michelle; Rhee, Eugene P.; Clish, Clary B.; Vasan, Ramachandran S.; Gerszten, Robert E.; Wang, Thomas J. (Public Library of Science, 2016)
      Background: Although obesity and cardiometabolic traits commonly overlap, underlying pathways remain incompletely defined. The association of metabolite profiles across multiple cardiometabolic traits may lend insights ...
    • Racial Differences in Circulating Natriuretic Peptide Levels: The Atherosclerosis Risk in Communities Study 

      Gupta, Deepak K; Claggett, Brian; Wells, Quinn; Cheng, Susan; Li, Man; Maruthur, Nisa; Selvin, Elizabeth; Coresh, Josef; Konety, Suma; Butler, Kenneth R; Mosley, Thomas; Boerwinkle, Eric; Hoogeveen, Ron; Ballantyne, Christie M; Solomon, Scott D (John Wiley & Sons, Ltd, 2015)
      Background: Natriuretic peptides promote natriuresis, diuresis, and vasodilation. Experimental deficiency of natriuretic peptides leads to hypertension (HTN) and cardiac hypertrophy, conditions more common among African ...
    • Regional Cardiac Dysfunction and Dyssynchrony in a Murine Model of Afterload Stress 

      Bauer, Michael; Cheng, Susan; Unno, Kazumasa; Lin, Fen-Chiung; Liao, Ronglih (Public Library of Science, 2013)
      Small animal models of afterload stress have contributed much to our present understanding of the progression from hypertension to heart failure. High-sensitivity methods for phenotyping cardiac function in vivo, particular ...
    • Relations of Central Hemodynamics and Aortic Stiffness with Left Ventricular Structure and Function: The Framingham Heart Study 

      Kaess, Bernhard M.; Rong, Jian; Larson, Martin G.; Hamburg, Naomi M.; Vita, Joseph A.; Cheng, Susan; Aragam, Jayashree; Levy, Daniel; Benjamin, Emelia J.; Vasan, Ramachandran S.; Mitchell, Gary F. (John Wiley and Sons Inc., 2016)
      Background: The differing relations of steady and pulsatile components of central hemodynamics and aortic stiffness with cardiac dimensions and function have not been fully elucidated. Methods and Results: Central hemodynamics ...