Now showing items 1-14 of 14

    • Conserved Genes Act as Modifiers of Invertebrate SMN Loss of Function Defects 

      Dimitriadi, Maria; Sleigh, James N.; Chang, Howard C.; Kalloo, Geetika; Harris, Jevede; Barsby, Tom; Walsh, Melissa B.; Satterlee, John S.; Li, Chris; Hart, Anne C.; Walker, Amy K.; Sen, Anindya Kumar; Van Vactor, David L.; Artavanis-Tsakonas, Spiro (Public Library of Science, 2010)
      Spinal Muscular Atrophy (SMA) is caused by diminished function of the Survival of Motor Neuron (SMN) protein, but the molecular pathways critical for SMA pathology remain elusive. We have used genetic approaches in ...
    • Drosophila Growth Cones Advance by Forward Translocation of the Neuronal Cytoskeletal Meshwork In Vivo 

      Roossien, Douglas H.; Lamoureux, Phillip; Van Vactor, David; Miller, Kyle E. (Public Library of Science, 2013)
      In vitro studies conducted in Aplysia and chick sensory neurons indicate that in addition to microtubule assembly, long microtubules in the C-domain of the growth cone move forward as a coherent bundle during axonal ...
    • Fak56 functions downstream of integrin alphaPS3betanu and suppresses MAPK activation in neuromuscular junction growth 

      Tsai, Pei-I; Kao, Hsiu-Hua; Grabbe, Caroline; Lee, Yu-Tao; Ghose, Aurnab; Lai, Tzu-Ting; Peng, Kuan-Po; Palmer, Ruth H; Chen, Ruey-Hwa; Yeh, Shih-Rung; Chien, Cheng-Ting; Van Vactor, David L. (BioMed Central, 2008)
      Background: Focal adhesion kinase (FAK) functions in cell migration and signaling through activation of the mitogen-activated protein kinase (MAPK) signaling cascade. Neuronal function of FAK has been suggested to control ...
    • Genetic and Functional Studies Implicate Synaptic Overgrowth and Ring Gland cAMP/PKA Signaling Defects in the Drosophila melanogaster Neurofibromatosis-1 Growth Deficiency 

      Walker, James A.; Gouzi, Jean Y.; Long, Jennifer B.; Huang, Sidong; Maher, Robert C.; Xia, Hongjing; Khalil, Kheyal; Ray, Arjun; Van Vactor, David; Bernards, René; Bernards, André (Public Library of Science, 2013)
      Neurofibromatosis type 1 (NF1), a genetic disease that affects 1 in 3,000, is caused by loss of a large evolutionary conserved protein that serves as a GTPase Activating Protein (GAP) for Ras. Among Drosophila melanogaster ...
    • Genetic Circuitry of Survival Motor Neuron, the Gene Underlying Spinal Muscular Atrophy 

      Sen, Anindya; Dimlich, Douglas; Guruharsha, K. G.; Kankel, Mark William; Hori, Kazuya; Yokokura, Takakazu; Brachat, Sophie; Richardson, Delwood; Loureiro, Joseph; Sivasankaran, Rajeev; Curtis, Daniel; Davidow, Lance Steven; Rubin, Lee; Hart, Anne C.; Van Vactor, David L.; Artavanis-Tsakonas, Spyros (Proceedings of the National Academy of Sciences, 2013)
      The clinical severity of the neurodegenerative disorder spinal muscular atrophy (SMA) is dependent on the levels of functional Survival Motor Neuron (SMN) protein. Consequently, current strategies for developing treatments ...
    • Growth cone-specific functions of XMAP215 in restricting microtubule dynamics and promoting axonal outgrowth 

      Lowery, Laura Anne; Stout, Alina; Faris, Anna E; Ding, Liya; Baird, Michelle A; Davidson, Michael W; Danuser, Gaudenz; Van Vactor, David (BioMed Central, 2013)
      Background: Microtubule (MT) regulators play essential roles in multiple aspects of neural development. In vitro reconstitution assays have established that the XMAP215/Dis1/TOG family of MT regulators function as MT ...
    • MicroRNA-8 promotes robust motor axon targeting by coordinate regulation of cell adhesion molecules during synapse development 

      Lu, Cecilia S.; Zhai, Bo; Mauss, Alex; Landgraf, Matthias; Gygi, Stephen; Van Vactor, David (The Royal Society, 2014)
      Neuronal connectivity and specificity rely upon precise coordinated deployment of multiple cell-surface and secreted molecules. MicroRNAs have tremendous potential for shaping neural circuitry by fine-tuning the spatio-temporal ...
    • MicroRNA-Dependent Transcriptional Silencing of Transposable Elements in Drosophila Follicle Cells 

      Mugat, Bruno; Akkouche, Abdou; Serrano, Vincent; Armenise, Claudia; Li, Blaise; Brun, Christine; Fulga, Tudor A.; Van Vactor, David; Pélisson, Alain; Chambeyron, Séverine (Public Library of Science, 2015)
      RNA interference-related silencing mechanisms concern very diverse and distinct biological processes, from gene regulation (via the microRNA pathway) to defense against molecular parasites (through the small interfering ...
    • miR-132 Enhances Dendritic Morphogenesis, Spine Density, Synaptic Integration, and Survival of Newborn Olfactory Bulb Neurons 

      Pathania, Manavendra; Torres-Reveron, Juan; Yan, Lily; Kimura, Tomoki; Lin, Tiffany V.; Gordon, Valerie; Teng, Zhao-Qian; Zhao, Xinyu; Fulga, Tudor A.; Bordey, Angélique; Van Vactor, David L. (Public Library of Science, 2012)
      An array of signals regulating the early stages of postnatal subventricular zone (SVZ) neurogenesis has been identified, but much less is known regarding the molecules controlling late stages. Here, we investigated the ...
    • Modeling Spinal Muscular Atrophy in Drosophila 

      Chang, Howard Chia-Hao; Yokokura, Takakazu; Mukherjee, Ashim; Kankel, Mark W.; Sridhar, Vasanthi; Hart, Anne C.; Dimlich, Douglas; Sen, Anindya Kumar; Fulga, Tudor Alexandru; Van Vactor, David L.; Artavanis-Tsakonas, Spiro (Public Library of Science, 2008)
      Spinal Muscular Atrophy (SMA), a recessive hereditary neurodegenerative disease in humans, has been linked to mutations in the survival motor neuron (SMN) gene. SMA patients display early onset lethality coupled with motor ...
    • Quality assessment and control of tissue specific RNA-seq libraries of Drosophila transgenic RNAi models 

      Amaral, Andreia J.; Brito, Francisco F.; Chobanyan, Tamar; Yoshikawa, Seiko; Yokokura, Takakazu; Van Vactor, David; Gama-Carvalho, Margarida (Frontiers Media S.A., 2014)
      RNA-sequencing (RNA-seq) is rapidly emerging as the technology of choice for whole-transcriptome studies. However, RNA-seq is not a bias free technique. It requires large amounts of RNA and library preparation can introduce ...
    • RNA and Protein Networks That Locally Control Brain Wiring During Development 

      Murphy, Alexander James (2015-05-14)
      The molecular machineries of growth cones control the formation of neural circuits in the developing brain. Although great progress has been made in elucidating axon guidance cues and their growth cone receptors, we still ...
    • Transcription Factor Networks in Drosophila melanogaster 

      Rhee, David Young (2013-10-08)
      Differential gene expression is an essential component of the programs that give rise to specific cellular fates and functions. This differential regulation occurs primarily at the transcriptional level and is controlled ...
    • A transgenic resource for conditional competitive inhibition of conserved Drosophila microRNAs 

      Fulga, Tudor A.; McNeill, Elizabeth M.; Binari, Richard; Yelick, Julia; Blanche, Alexandra; Booker, Matthew; Steinkraus, Bruno R.; Schnall-Levin, Michael; Zhao, Yong; DeLuca, Todd; Bejarano, Fernando; Han, Zhe; Lai, Eric C.; Wall, Dennis P.; Perrimon, Norbert; Van Vactor, David (Nature Pub. Group, 2015)
      Although the impact of microRNAs (miRNAs) in development and disease is well established, understanding the function of individual miRNAs remains challenging. Development of competitive inhibitor molecules such as miRNA ...