Browsing by Author "Lu, Junjie"
Now showing items 1-4 of 4
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The Distribution of Genomic Variations in Human iPSCs Is Related to Replication-Timing Reorganization during Reprogramming
Lu, Junjie; Hu, Ming; Li, Hu; Sasaki, Takayo; Baccei, Anna; Gilbert, David M.; Liu, Jun; Collins, James J.; Lerou, Paul Hubert (Elsevier BV, 2014)Cell fate change involves significant genome reorganization, including change in replication timing, but how these changes are related to genetic variation has not been examined. To study how change in replication timing ... -
Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids
Freedman, Benjamin S.; Brooks, Craig R.; Lam, Albert Q.; Fu, Hongxia; Morizane, Ryuji; Agrawal, Vishesh; Saad, Abdelaziz F.; Li, Michelle K.; Hughes, Michael R.; Werff, Ryan Vander; Peters, Derek T.; Lu, Junjie; Baccei, Anna; Siedlecki, Andrew M.; Valerius, M. Todd; Musunuru, Kiran; McNagny, Kelly M.; Steinman, Theodore I.; Zhou, Jing; Lerou, Paul H.; Bonventre, Joseph V. (Nature Pub. Group, 2015)Human-pluripotent-stem-cell-derived kidney cells (hPSC-KCs) have important potential for disease modelling and regeneration. Whether the hPSC-KCs can reconstitute tissue-specific phenotypes is currently unknown. Here we ... -
Multi-Scale Imaging and Informatics Pipeline for In Situ Pluripotent Stem Cell Analysis
Gorman, Bryan R.; Lu, Junjie; Baccei, Anna; Lowry, Nathan C.; Purvis, Jeremy E.; Mangoubi, Rami S.; Lerou, Paul H. (Public Library of Science, 2014)Human pluripotent stem (hPS) cells are a potential source of cells for medical therapy and an ideal system to study fate decisions in early development. However, hPS cells cultured in vitro exhibit a high degree of ... -
Relevant Mouse Model for Human Monocytic Leukemia through Cre/lox-Controlled Myeloid-Specific Deletion of PTEN
Yu, H.; Li, Yili; Gao, Chuanyun; Fabien, L.; Jia, Y.; Lu, Junjie; Silberstein, Leslie E.; Pinkus, Geraldine Sowinski; Ye, K.; Chai, Li; Luo, Hongbo (Nature Publishing Group, 2010)