Browsing by Author "Kuzontkoski, Paula Marie"

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Slit2/Robo4 Signaling Modulates HIV-1 gp120-Induced Lymphatic Hyperpermeability

Zhang, Xeufeng; Yu, JinLong; Kuzontkoski, Paula Marie; Zhu, Weiquan; Li, Dean Y.; Groopman, Jerome Elliot (Public Library of Science, 2012)

Dissemination of HIV in the host involves transit of the virus and virus-infected cells across the lymphatic endothelium. HIV may alter lymphatic endothelial permeability to foster dissemination, but the mechanism is largely ...
Slit2N and Robo4 regulate lymphangiogenesis through the VEGF-C/VEGFR-3 pathway

Yu, Jinlong; Zhang, Xuefeng; Kuzontkoski, Paula M; Jiang, Shuxian; Zhu, Weiquan; Li, Dean Y; Groopman, Jerome E (BioMed Central, 2014)

Background: Signaling through vascular endothelial growth factor C (VEGF–C) and VEGF receptor 3 (VEGFR-3) plays a central role in lymphangiogenesis and the metastasis of several cancers via the lymphatics. Recently, the ...
Slit2N/Robo1 Inhibit HIV-gp120-Induced Migration and Podosome Formation in Immature Dendritic Cells by Sequestering LSP1 and WASp

Prasad, Anil; Kuzontkoski, Paula Marie; Shrivastava, Ashutosh; Zhu, Weiquan; Li, Dean Y.; Groopman, Jerome Elliot (Public Library of Science, 2012)

Cell-mediated transmission and dissemination of sexually-acquired human immunodeficiency virus 1 (HIV-1) in the host involves the migration of immature dendritic cells (iDCs). iDCs migrate in response to the HIV-1 envelope ...