Now showing items 1-13 of 13

    • Blocking the formation of radiation–induced breast cancer stem cells 

      Wang, Yangyang; Li, Wende; Patel, Shalin S.; Cong, Juan; Zhang, Nan; Sabbatino, Francesco; Liu, Xiaoyan; Qi, Yuan; Huang, Peigen; Lee, Hang; Taghian, Alphonse; Li, Jian-Jian; DeLeo, Albert B.; Ferrone, Soldano; Epperly, Michael W.; Ferrone, Cristina R.; Ly, Amy; Brachtel, Elena F.; Wang, Xinhui (Impact Journals LLC, 2014)
      The goal of adjuvant (post-surgery) radiation therapy (RT) for breast cancer (BC) is to eliminate residual cancer cells, leading to better local tumor control and thus improving patient survival. However, radioresistance ...
    • EGFR-mediated tumor immunoescape: The imbalance between phosphorylated STAT1 and phosphorylated STAT3 

      Concha-Benavente, Fernando; Srivastava, Raghvendra M; Ferrone, Soldano; Ferris, Robert L (Landes Bioscience, 2013)
      The epidermal growth factor receptor (EGFR) supports the escape of malignant cells from immunosurveillance by inhibiting the activation of signal transducer and activator of transcription 1 (STAT1) while promoting that of ...
    • Enhancement of anti-leukemia activity of NK cells in vitro and in vivo by inhibition of leukemia cell-induced NK cell damage 

      Arriga, Roberto; Caratelli, Sara; Coppola, Andrea; Spagnoli, Giulio Cesare; Venditti, Adriano; Amadori, Sergio; Lanzilli, Giulia; Lauro, Davide; Palomba, Patrizia; Sconocchia, Tommaso; Del Principe, Maria Ilaria; Maurillo, Luca; Buccisano, Francesco; Capuani, Barbara; Ferrone, Soldano; Sconocchia, Giuseppe (Impact Journals LLC, 2016)
      Acute myeloid leukemia (AML) cells induce, in vitro, NK cell abnormalities (NKCAs) including apoptosis and activating receptor down-regulation. The potential negative impact of AML cells on the therapeutic efficacy of NK ...
    • Enrichment of CD56dimKIR+CD57+ highly cytotoxic NK cells in tumor infiltrated lymph nodes of melanoma patients 

      Ali, Talib Hassan; Pisanti, Simona; Ciaglia, Elena; Mortarini, Roberta; Anichini, Andrea; Garofalo, Cinzia; Tallerico, Rossana; Santinami, Mario; Gulletta, Elio; Ietto, Caterina; Galgani, Mario; Matarese, Giuseppe; Bifulco, Maurizio; Ferrone, Soldano; Colucci, Francesco; Moretta, Alessandro; Kärre, Klas; Carbone, Ennio (2014)
      An important checkpoint in the progression of melanoma is the metastasis to lymph nodes. Here, to investigate the role of lymph node NK cells in disease progression, we analyze frequency, phenotype and functions of NK cells ...
    • Future perspectives in melanoma research. Meeting report from the “Melanoma Bridge. Napoli, December 2nd-4th 2012” 

      Ascierto, Paolo A; Grimaldi, Antonio M; Acquavella, Nicolas; Borgognoni, Lorenzo; Calabrò, Luana; Cascinelli, Natale; Cesano, Alessandra; Del Vecchio, Michele; Eggermont, Alexander M; Faries, Mark; Ferrone, Soldano; Fox, Bernard A; Gajewski, Thomas F; Galon, Jérôme; Gnjatic, Sacha; Gogas, Helen; Kashani-Sabet, Mohammed; Kaufman, Howard L; Larkin, James; Lo, Roger S; Mantovani, Alberto; Margolin, Kim; Melief, Cornelis; McArthur, Grant; Palmieri, Giuseppe; Puzanov, Igor; Ribas, Antoni; Seliger, Barbara; Sosman, Jeff; Suenaert, Peter; Tarhini, Ahmad A; Trinchieri, Giorgio; Vidal-Vanaclocha, Fernando; Wang, Ena; Ciliberto, Gennaro; Mozzillo, Nicola; Marincola, Francesco M; Thurin, Magdalena (BioMed Central, 2013)
      Recent insights into the genetic and somatic aberrations have initiated a new era of rapidly evolving targeted and immune-based treatments for melanoma. After decades of unsuccessful attempts to finding a more effective ...
    • Future perspectives in melanoma research: meeting report from the “Melanoma Bridge”, Napoli, December 5th-8th 2013 

      Ascierto, Paolo A; Grimaldi, Antonio M; Anderson, Ana Carrizosa; Bifulco, Carlo; Cochran, Alistair; Garbe, Claus; Eggermont, Alexander M; Faries, Mark; Ferrone, Soldano; Gershenwald, Jeffrey E; Gajewski, Thomas F; Halaban, Ruth; Hodi, F Stephen; Kefford, Richard; Kirkwood, John M; Larkin, James; Leachman, Sancy; Maio, Michele; Marais, Richard; Masucci, Giuseppe; Melero, Ignacio; Palmieri, Giuseppe; Puzanov, Igor; Ribas, Antoni; Saenger, Yvonne; Schilling, Bastian; Seliger, Barbara; Stroncek, David; Sullivan, Ryan; Testori, Alessandro; Wang, Ena; Ciliberto, Gennaro; Mozzillo, Nicola; Marincola, Francesco M; Thurin, Magdalena (BioMed Central, 2014)
      The fourth “Melanoma Bridge Meeting” took place in Naples, December 5 to 8th, 2013. The four topics discussed at this meeting were: Diagnosis and New Procedures, Molecular Advances and Combination Therapies, News in ...
    • Future perspectives in melanoma research: Meeting report from the “Melanoma Bridge”. Napoli, December 1st–4th 2015 

      Ascierto, Paolo A.; Agarwala, Sanjiv; Botti, Gerardo; Cesano, Alessandra; Ciliberto, Gennaro; Davies, Michael A.; Demaria, Sandra; Dummer, Reinhard; Eggermont, Alexander M.; Ferrone, Soldano; Fu, Yang Xin; Gajewski, Thomas F.; Garbe, Claus; Huber, Veronica; Khleif, Samir; Krauthammer, Michael; Lo, Roger S.; Masucci, Giuseppe; Palmieri, Giuseppe; Postow, Michael; Puzanov, Igor; Silk, Ann; Spranger, Stefani; Stroncek, David F.; Tarhini, Ahmad; Taube, Janis M.; Testori, Alessandro; Wang, Ena; Wargo, Jennifer A.; Yee, Cassian; Zarour, Hassane; Zitvogel, Laurence; Fox, Bernard A.; Mozzillo, Nicola; Marincola, Francesco M.; Thurin, Magdalena (BioMed Central, 2016)
      The sixth “Melanoma Bridge Meeting” took place in Naples, Italy, December 1st–4th, 2015. The four sessions at this meeting were focused on: (1) molecular and immune advances; (2) combination therapies; (3) news in ...
    • Future perspectives in melanoma research: meeting report from the “Melanoma Bridge”: Napoli, December 3rd–6th 2014 

      Ascierto, Paolo A.; Atkins, Michael; Bifulco, Carlo; Botti, Gerardo; Cochran, Alistair; Davies, Michael; Demaria, Sandra; Dummer, Reinhard; Ferrone, Soldano; Formenti, Silvia; Gajewski, Thomas F.; Garbe, Claus; Khleif, Samir; Kiessling, Rolf; Lo, Roger; Lorigan, Paul; Arthur, Grant Mc; Masucci, Giuseppe; Melero, Ignacio; Mihm, Martin; Palmieri, Giuseppe; Parmiani, Giorgio; Puzanov, Igor; Romero, Pedro; Schilling, Bastian; Seliger, Barbara; Stroncek, David; Taube, Janis; Tomei, Sara; Zarour, Hassane M.; Testori, Alessandro; Wang, Ena; Galon, Jérôme; Ciliberto, Gennaro; Mozzillo, Nicola; Marincola, Francesco M.; Thurin, Magdalena (BioMed Central, 2015)
      The fourth “Melanoma Bridge Meeting” took place in Naples, December 3–6th, 2014. The four topics discussed at this meeting were: Molecular and Immunological Advances, Combination Therapies, News in Immunotherapy, and Tumor ...
    • HLA class I downregulation is associated with enhanced NK‐cell killing of melanoma cells with acquired drug resistance to BRAF inhibitors 

      Sottile, Rosa; Pangigadde, Pradeepa N.; Tan, Thomas; Anichini, Andrea; Sabbatino, Francesco; Trecroci, Francesca; Favoino, Elvira; Orgiano, Laura; Roberts, James; Ferrone, Soldano; Kärre, Klas; Colucci, Francesco; Carbone, Ennio (John Wiley and Sons Inc., 2015)
      The frequent development of drug resistance to targeted therapies in cancer patients has stimulated interest in strategies counteracting resistance. Combining immunotherapies with targeted therapies is one such strategy. ...
    • Ipilimumab in the treatment of metastatic melanoma: management of adverse events 

      Della Vittoria Scarpati, Giuseppina; Fusciello, Celeste; Perri, Francesco; Sabbatino, Francesco; Ferrone, Soldano; Carlomagno, Chiara; Pepe, Stefano (Dove Medical Press, 2014)
      Recently, “ipilimumab,” an anti-cytotoxic T-lymphocyte antigen-4 (CTLA-4) monoclonal antibody, has been demonstrated to improve overall survival in metastatic melanoma. “CTLA-4” is an immune-checkpoint molecule that ...
    • Melanoma and immunotherapy bridge 2015: Naples, Italy. 1–5 December 2015 

      Nanda, Vashisht G. Y.; Peng, Weiyi; Hwu, Patrick; Davies, Michael A.; Ciliberto, Gennaro; Fattore, Luigi; Malpicci, Debora; Aurisicchio, Luigi; Ascierto, Paolo Antonio; Croce, Carlo M.; Mancini, Rita; Spranger, Stefani; Gajewski, Thomas F.; Wang, Yangyang; Ferrone, Soldano; Vanpouille-Box, Claire; Wennerberg, Erik; Pilones, Karsten A.; Formenti, Silvia C.; Demaria, Sandra; Tang, Haidong; Wang, Yang; Fu, Yang-Xin; Dummer, Reinhard; Puzanov, Igor; Tarhini, Ahmad; Chauvin, Joe-Marc; Pagliano, Ornella; Fourcade, Julien; Sun, Zhaojun; Wang, Hong; Sanders, Cindy; Kirkwood, John M.; Chen, Tseng-hui Timothy; Maurer, Mark; Korman, Alan J.; Zarour, Hassane M.; Stroncek, David F.; Huber, Veronica; Rivoltini, Licia; Thurin, Magdalena; Rau, Tilman; Lugli, Alessandro; Pagès, Franck; Camarero, Jorge; Sancho, Arantxa; Jommi, Claudio; de Coaña, Yago Pico; Wolodarski, Maria; Yoshimoto, Yuya; Gentilcore, Giusy; Poschke, Isabel; Masucci, Giuseppe V.; Hansson, Johan; Kiessling, Rolf; Scognamiglio, Giosuè; Sabbatino, Francesco; Marino, Federica Zito; Anniciello, Anna Maria; Cantile, Monica; Cerrone, Margherita; Scala, Stefania; D’alterio, Crescenzo; Ianaro, Angela; Cirin, Giuseppe; Liguori, Giuseppina; Bott, Gerardo; Chapman, Paul B.; Robert, Caroline; Larkin, James; Haanen, John B.; Ribas, Antoni; Hogg, David; Hamid, Omid; Testori, Alessandro; Lorigan, Paul; Sosman, Jeffrey A.; Flaherty, Keith T.; Yue, Huibin; Coleman, Shelley; Caro, Ivor; Hauschild, Axel; McArthur, Grant A.; Sznol, Mario; Callahan, Margaret K.; Kluger, Harriet; Postow, Michael A.; Gordan, RuthAnn; Segal, Neil H.; Rizvi, Naiyer A.; Lesokhin, Alexander; Atkins, Michael B.; Burke, Matthew M.; Ralabate, Amanda; Rivera, Angel; Kronenberg, Stephanie A.; Agunwamba, Blessing; Ruisi, Mary; Horak, Christine; Jiang, Joel; Wolchok, Jedd; Ascierto, Paolo A.; Liszkay, Gabriella; Maio, Michele; Mandalà, Mario; Demidov, Lev; Stoyakovskiy, Daniil; Thomas, Luc; de la Cruz-Merino, Luis; Atkinson, Victoria; Dutriaux, Caroline; Garbe, Claus; Wongchenko, Matthew; Chang, Ilsung; Koralek, Daniel O.; Rooney, Isabelle; Yan, Yibing; Dréno, Brigitte; Sullivan, Ryan; Patel, Manish; Hodi, Stephen; Amaria, Rodabe; Boasberg, Peter; Wallin, Jeffrey; He, Xian; Cha, Edward; Richie, Nicole; Ballinger, Marcus; Smith, David C.; Bauer, Todd M.; Wasser, Jeffrey S.; Luke, Jason J.; Balmanoukian, Ani S.; Kaufman, David R.; Zhao, Yufan; Maleski, Janet; Leopold, Lance; Gangadhar, Tara C.; Long, Georgina V.; Michielin, Olivier; VanderWalde, Ari; Andtbacka, Robert H. I.; Cebon, Jonathan; Fernandez, Eugenio; Malvehy, Josep; Olszanski, Anthony J.; Gause, Christine; Chen, Lisa; Chou, Jeffrey; Stephen Hodi, F.; Brady, Benjamin; Mortier, Laurent; Hassel, Jessica C.; Rutkowski, Piotr; McNeil, Catriona; Kalinka-Warzocha, Ewa; Lebbé, Celeste; Ny, Lars; Chacon, Matias; Queirolo, Paola; Loquai, Carmen; Cheema, Parneet; Berrocal, Alfonso; Eizmendi, Karmele Mujika; Bar-Sela, Gil; Hardy, Helene; Weber, Jeffrey S.; Grob, Jean-Jacques; Marquez-Rodas, Ivan; Schmidt, Henrik; Briscoe, Karen; Baurain, Jean-François; Wolchok, Jedd D.; Pinto, Rosamaria; De Summa, Simona; Garrisi, Vito Michele; Strippoli, Sabino; Azzariti, Amalia; Guida, Gabriella; Guida, Michele; Tommasi, Stefania; Jacquelot, Nicolas; Enot, David; Flament, Caroline; Pitt, Jonathan M.; Vimond, Nadège; Blattner, Carolin; Yamazaki, Takahiro; Roberti, Maria-Paula; Vetizou, Marie; Daillere, Romain; Poirier-Colame, Vichnou; la Semeraro, Michaë; Caignard, Anne; Slingluff, Craig L; Sallusto, Federica; Rusakiewicz, Sylvie; Weide, Benjamin; Marabelle, Aurélien; Kohrt, Holbrook; Dalle, Stéphane; Cavalcanti, Andréa; Kroemer, Guido; Di Giacomo, Anna Maria; Maio, Michaele; Wong, Phillip; Yuan, Jianda; Umansky, Viktor; Eggermont, Alexander; Zitvogel, Laurence; Anna, Passarelli; Marco, Tucci; Stefania, Stucci; Francesco, Mannavola; Mariaelena, Capone; Gabriele, Madonna; Antonio, Ascierto Paolo; Franco, Silvestris; Roberti, María Paula; Enot, David P.; Semeraro, Michaela; Jégou, Sarah; Flores, Camila; Kwon, Byoung S.; Anderson, Ana Carrizossa; Borg, Christophe; Aubin, François; Ayyoub, Maha; De Presbiteris, Anna Lisa; Cordaro, Fabiola Gilda; Camerlingo, Rosa; Fratangelo, Federica; Mozzillo, Nicola; Pirozzi, Giuseppe; Patriarca, Eduardo J.; Caputo, Emilia; Motti, Maria Letizia; Falcon, Rosaria; Miceli, Roberta; Capone, Mariaelena; Madonna, Gabriele; Mallardo, Domenico; Carrier, Maria Vincenza; Panza, Elisabetta; De Cicco, Paola; Armogida, Chiara; Ercolano, Giuseppe; Botti, Gerardo; Cirino, Giuseppe; Sandru, Angela; Blank, Miri; Balatoni, Timea; Olasz, Judit; Farkas, Emil; Szollar, Andras; Savolt, Akos; Godeny, Maria; Csuka, Orsolya; Horvath, Szabolcs; Eles, Klara; Shoenfeld, Yehuda; Kasler, Miklos; Costantini, Susan; Capone, Francesca; Moradi, Farnaz; Berglund, Pontus; Leandersson, Karin; Linnskog, Rickard; Andersson, Tommy; Prasad, Chandra Prakash; Nigro, Cristiana Lo; Lattanzio, Laura; Wang, Hexiao; Proby, Charlotte; Syed, Nelofer; Occelli, Marcella; Cauchi, Carolina; Merlano, Marco; Harwood, Catherine; Thompson, Alastair; Crook, Tim; Bifulco, Katia; Ingangi, Vincenzo; Minopoli, Michele; Ragone, Concetta; Pessi, Antonello; Mannavola, Francesco; D’Oronzo, Stella; Felici, Claudia; Tucci, Marco; Doronzo, Antonio; Silvestris, Franco; Ferretta, Anna; Guida, Stefania; Maida, Imma; Cocco, Tiziana; Passarelli, Anna; Quaresmini, Davide; Franzese, Ornella; Palermo, Belinda; Di Donna, Cosmo; Sperduti, Isabella; Foddai, MariaLaura; Stabile, Helena; Gismondi, Angela; Santoni, Angela; Nisticò, Paola; Sponghini, Andrea P.; Platini, Francesca; Marra, Elena; Rondonotti, David; Alabiso, Oscar; Fierro, Maria T.; Savoia, Paola; Stratica, Florian; Quaglino, Pietro; Di Monta, Gianluca; Corrado, Caracò; Di Marzo, Massimiliano; Ugo, Marone; Di Cecilia, Maria Luisa; Nicola, Mozzillo; Fusciello, Celeste; Marra, Antonio; Guarrasi, Rosario; Baldi, Carlo; Russo, Rosa; Di Giulio, Giovanni; Faiola, Vincenzo; Zeppa, Pio; Pepe, Stefano; Gambale, Elisabetta; Carella, Consiglia; Di Paolo, Alessandra; De Tursi, Michele; Marra, Laura; De Murtas, Fara; Sorrentino, Valeria; Voinea, Silviu; Panaitescu, Eugenia; Bolovan, Madalina; Stanciu, Adina; Cinca, Sabin; Botti, Chiara; Aquino, Gabriella; Anniciello, Annamaria; Fortes, Cristina; Mastroeni, Simona; Caggiati, Alessio; Passarelli, Francesca; Zappalà, Alba; Capuano, Maria; Bono, Riccardo; Nudo, Maurizio; Marino, Claudia; Michelozzi, Paola; De Biasio, Valeria; Battarra, Vincenzo C.; Formenti, Silvia; Ascierto, Maria Libera; McMiller, Tracee L.; Berger, Alan E.; Danilova, Ludmila; Anders, Robert A.; Netto, George J.; Xu, Haiying; Pritchard, Theresa S.; Fan, Jinshui; Cheadle, Chris; Cope, Leslie; Drake, Charles G.; Pardoll, Drew M.; Taube, Janis M.; Topalian, Suzanne L.; Gnjatic, Sacha; Nataraj, Sarah; Imai, Naoko; Rahman, Adeeb; Jungbluth, Achim A.; Pan, Linda; Venhaus, Ralph; Park, Andrew; Lehmann, Frédéric F.; Lendvai, Nikoletta; Cohen, Adam D.; Cho, Hearn J.; Daniel, Speiser; Hirsh, Vera (BioMed Central, 2016)
      Table of contents MELANOMA BRIDGE 2015 KEYNOTE SPEAKER PRESENTATIONS Molecular and immuno-advances K1 Immunologic and metabolic consequences of PI3K/AKT/mTOR activation in melanoma Vashisht G. Y. Nanda, Weiyi Peng, Patrick ...
    • PDGFRα up-regulation mediated by sonic hedgehog pathway activation leads to BRAF inhibitor resistance in melanoma cells with BRAF mutation 

      Sabbatino, Francesco; Wang, Yangyang; Wang, Xinhui; Flaherty, Keith T.; Yu, Ling; Pepin, David; Scognamiglio, Giosue'; Pepe, Stefano; Kirkwood, John M.; Cooper, Zachary A.; Frederick, Dennie T.; Wargo, Jennifer A.; Ferrone, Soldano; Ferrone, Cristina R. (Impact Journals LLC, 2014)
      Control of BRAF(V600E) metastatic melanoma by BRAF inhibitor (BRAF-I) is limited by intrinsic and acquired resistance. Growth factor receptor up-regulation is among the mechanisms underlying BRAF-I resistance of melanoma ...
    • Stem cells and cancer immunotherapy: Arrowhead’s 2nd annual cancer immunotherapy conference 

      Bot, Adrian; Chiriva-Internati, Maurizio; Cornforth, Andrew; Czerniecki, Brian J; Ferrone, Soldano; Geles, Kenneth; Greenberg, Philip D; Hurt, Elaine; Koya, Richard C; Manjili, Masoud H; Matsui, William; Morgan, Richard A; Palena, Claudia M; Powell Jr , Daniel J; Restifo, Nicholas P; Spencer, David M; Vizcardo, Raul; Wong, Albert J; Yang, Lili; Yu, John (BioMed Central, 2014)
      Investigators from academia and industry gathered on April 4 and 5, 2013, in Washington DC at the Arrowhead’s 2nd Annual Cancer Immunotherapy Conference. Two complementary concepts were discussed: cancer “stem cells” as ...