Browsing by Author "Gertner, Rona"

Now showing items 1-4 of 4

    • Nanowire-Mediated Delivery Enables Functional Interrogation of Primary Immune Cells: Application to the Analysis of Chronic Lymphocytic Leukemia 

      Shalek, Alexander Kann; Gaublomme, Jellert Thomas; Wang, Lili; Yosef, Nir; Chevrier, Nicolas; Andersen, Mette S.; Robinson, Jacob T.; Pochet, Nathalie; Neuberg, Donna S.; Gertner, Rona S.; Amit, Ido; Brown, Jennifer Ruth; Hacohen, Nir; Regev, Aviv; Wu, Cathy Ju-Ying; Park, Hongkun (American ChemicalSociety, 2012)
      A circuit level understanding of immune cells and hematological cancers has been severely impeded by a lack of techniques that enable intracellular perturbation without significantly altering cell viability and function. ...

    • Nuclear magnetic resonance detection and spectroscopy of single proteins using quantum logic 

      Lovchinsky, Igor; Sushkov, Alexander; Urbach, Elana Kahn; de Leon, N; Choi, Soonwon; De Greve, Kristiaan; Evans, Ruffin Eley; Gertner, Rona S.; Bersin, Eric Alexander; Muller, C; McGuinness, L.; Jelezko, F.; Walsworth, Ronald Lee; Park, Hongkun; Lukin, Mikhail D. (American Association for the Advancement of Science (AAAS), 2016)
      Nuclear magnetic resonance spectroscopy is a powerful tool for the structural analysis of organic compounds and biomolecules but typically requires macroscopic sample quantities. We use a sensor, which consists of two ...

    • Single cell RNA Seq reveals dynamic paracrine control of cellular variation 

      Shalek, Alex K.; Satija, Rahul; Shuga, Joe; Trombetta, John J.; Gennert, Dave; Lu, Diana; Chen, Peilin; Gertner, Rona S.; Gaublomme, Jellert T.; Yosef, Nir; Schwartz, Schraga; Fowler, Brian; Weaver, Suzanne; Wang, Jing; Wang, Xiaohui; Ding, Ruihua; Raychowdhury, Raktima; Friedman, Nir; Hacohen, Nir; Park, Hongkun; May, Andrew P.; Regev, Aviv (2014)
      High-throughput single-cell transcriptomics offers an unbiased approach for understanding the extent, basis, and function of gene expression variation between seemingly identical cells. Here, we sequence single-cell RNA-Seq ...

    • Single-cell transcriptomics reveals bimodality in expression and splicing in immune cells 

      Shalek, Alex K.; Satija, Rahul; Adiconis, Xian; Gertner, Rona S.; Gaublomme, Jellert T.; Raychowdhury, Raktima; Schwartz, Schragi; Yosef, Nir; Malboeuf, Christine; Lu, Diana; Trombetta, John T.; Gennert, Dave; Gnirke, Andreas; Goren, Alon; Hacohen, Nir; Levin, Joshua Z.; Park, Hongkun; Regev, Aviv (2013)
      Recent molecular studies have revealed that, even when derived from a seemingly homogenous population, individual cells can exhibit substantial differences in gene expression, protein levels, and phenotypic output1–5, with ...