Browsing by Author "Rajagopal, Jayaraj"

Now showing items 1-7 of 7

    • Dedifferentiation of committed epithelial cells into stem cells in vivo 

      Tata, Purushothama Rao; Mou, Hongmei; Pardo-Saganta, Ana; Zhao, Rui; Prabhu, Mythili; Law, Brandon M.; Vinarsky, Vladimir; Cho, Josalyn L.; Breton, Sylvie; Sahay, Amar; Medoff, Benjamin D.; Rajagopal, Jayaraj (2014)
      Summary Cellular plasticity contributes to the regenerative capacity of plants, invertebrates, teleost fishes, and amphibians. In vertebrates, differentiated cells are known to revert into replicating progenitors, but these ...

    • Generation of Multipotent Lung and Airway Progenitors from Mouse ESCs and Patient-Specific Cystic Fibrosis iPSCs 

      Mou, Hongmei; Zhao, Rui; Sherwood, Richard Irving; Ahfeldt, Tim; Lapey, Allen; Wain, John Charles; Sicilian, Leonard; Izvolsky, Konstantin; Lau, Frank; Musunuru, Kiran; Cowan, Chad A.; Rajagopal, Jayaraj (Elsevier BV, 2012)
      Deriving lung progenitors from patient-specific pluripotent cells is a key step in producing differentiated lung epithelium for disease modeling and transplantation. By mimicking the signaling events that occur during mouse ...

    • Genetic Targeting of the Endoderm with Claudin-6CreER 

      Anderson, William J.; Zhou, Qiao; Alcalde, Victor; Kaneko, Osamu F; Blank, Leah J; Sherwood, Richard Irving; Guseh, James Sawalla; Rajagopal, Jayaraj; Melton, Douglas A. (Wiley-Blackwell, 2008)
      A full description of the ontogeny of the β cell would guide efforts to generate β cells from embryonic stem cells (ESCs). The first step requires an understanding of definitive endoderm: the genes and signals responsible ...

    • Lineage and Functional Analyses of Specific Subsets of Retinal Progenitor Cells 

      You, Wenjia (2015-05-21)
      The vertebrate central nervous system (CNS) is made up of a diverse array of cell types. The retina, an accessible part of the CNS with seven major cell types and more than sixty cell subtypes, is an excellent model system ...

    • A Multipotent Progenitor Domain Guides Pancreatic Organogenesis 

      Zhou, Qiao; Law, Anica Chi-Ying; Rajagopal, Jayaraj; Anderson, William J.; Gray, Paul A.; Melton, Douglas A. (Elsevier BV, 2007)
      The mammalian pancreas is constructed during embryogenesis by multipotent progenitors, the identity and function of which remain poorly understood. We performed genome-wide transcription factor expression analysis of the ...

    • Notch signaling promotes airway mucous metaplasia and inhibits alveolar development 

      Guseh, James Sawalla; Bores, S. A.; Stanger, B. Z.; Zhou, Qiao; Anderson, William J.; Melton, Douglas A.; Rajagopal, Jayaraj (The Company of Biologists, 2009)
      The airways are conduits that transport atmospheric oxygen to the distal alveolus. Normally, airway mucous cells are rare. However, diseases of the airway are often characterized by mucous metaplasia, in which there are ...

    • Specific bone cells produce DLL4 to generate thymus-seeding progenitors from bone marrow 

      Yu, Vionnie W.C.; Saez, Borja; Cook, Colleen; Lotinun, Sutada; Pardo-Saganta, Ana; Wang, Ying-Hua; Lymperi, Stefania; Ferraro, Francesca; Raaijmakers, Marc H.G.P.; Wu, Joy Y.; Zhou, Lan; Rajagopal, Jayaraj; Kronenberg, Henry M.; Baron, Roland; Scadden, David T. (The Rockefeller University Press, 2015)
      Production of the cells that ultimately populate the thymus to generate α/β T cells has been controversial, and their molecular drivers remain undefined. Here, we report that specific deletion of bone-producing osteocalcin ...