Browsing by Author "Butovsky, Oleg"

Now showing items 1-4 of 4

    • Dark microglia: A new phenotype predominantly associated with pathological states 

      Bisht, Kanchan; Sharma, Kaushik P.; Lecours, Cynthia; Gabriela Sánchez, Maria; El Hajj, Hassan; Milior, Giampaolo; Olmos‐Alonso, Adrián; Gómez‐Nicola, Diego; Luheshi, Giamal; Vallières, Luc; Branchi, Igor; Maggi, Laura; Limatola, Cristina; Butovsky, Oleg; Tremblay, Marie‐Ève (John Wiley and Sons Inc., 2016)
      The past decade has witnessed a revolution in our understanding of microglia. These immune cells were shown to actively remodel neuronal circuits, leading to propose new pathogenic mechanisms. To study microglial implication ...

    • Differential roles of microglia and monocytes in the inflamed central nervous system 

      Yamasaki, Ryo; Lu, Haiyan; Butovsky, Oleg; Ohno, Nobuhiko; Rietsch, Anna M.; Cialic, Ron; Wu, Pauline M.; Doykan, Camille E.; Lin, Jessica; Cotleur, Anne C.; Kidd, Grahame; Zorlu, Musab M.; Sun, Nathan; Hu, Weiwei; Liu, LiPing; Lee, Jar-Chi; Taylor, Sarah E.; Uehlein, Lindsey; Dixon, Debra; Gu, Jinyu; Floruta, Crina M.; Zhu, Min; Charo, Israel F.; Weiner, Howard L.; Ransohoff, Richard M. (The Rockefeller University Press, 2014)
      In the human disorder multiple sclerosis (MS) and in the model experimental autoimmune encephalomyelitis (EAE), macrophages predominate in demyelinated areas and their numbers correlate to tissue damage. Macrophages may ...

    • Identification of a Unique TGF-β Dependent Molecular and Functional Signature in Microglia 

      Butovsky, Oleg; Jedrychowski, Mark P.; Moore, Craig S.; Cialic, Ron; Lanser, Amanda J.; Gabriely, Galina; Koeglsperger, Thomas; Dake, Ben; Wu, Pauline M.; Doykan, Camille E.; Fanek, Zain; Liu, LiPing; Chen, Zhuoxun; Rothstein, Jeffrey D.; Ransohoff, Richard M.; Gygi, Steven P.; Antel, Jack P.; Weiner, Howard L. (2014)
      Microglia are myeloid cells of the central nervous system (CNS) that participate both in normal CNS function and disease. We investigated the molecular signature of microglia and identified 239 genes and 8 microRNAs that ...

    • P2Y12 expression and function in alternatively activated human microglia 

      Moore, Craig S.; Ase, Ariel R.; Kinsara, Angham; Rao, Vijayaraghava T.S.; Michell-Robinson, Mackenzie; Leong, Soo Yuen; Butovsky, Oleg; Ludwin, Samuel K.; Séguéla, Philippe; Bar-Or, Amit; Antel, Jack P. (Lippincott Williams & Wilkins, 2015)
      Objective: To investigate and measure the functional significance of altered P2Y12 expression in the context of human microglia activation. Methods: We performed in vitro and in situ experiments to measure how P2Y12 ...